Synthetic Route of 210532-25-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 210532-25-5 as follows.
1-(ethylsulfonyl)-3-fluorobenzene A stirred mixture of 3-fluorobenzenesulfonyl chloride (0.973 g, 5.00 mmol), sodium bicarbonate (0.84 g, 10.0 mmol), and sodium sulfite (1.16 g, mmol) was heated in water (7 mL) at 95-100 C. for 1 h under nitrogen. The reaction was cooled to ~50 C., treated with (nBu)4NBr (100 mg) and ethyl iodide (2.5 mL) and heated at 70 C. for 18 h. The reaction was cooled, treated with water (10 mL) and extracted with dichloromethane (3*15 mL). The extracts were dried with MgSO4 and concentrated in vacuo. Chromatography on silica gel eluding with an ethyl acetate:hexane gradient of 10:90 to 40/60 gave the title compound as a colorless oil (878 mg). MS (ES) m/z 189.0. Intermediates 2 to 11; 13-14Prepared according to a procedure similar to that described for Intermediate 1, using the appropriate halogenated arylsulfonylchloride and alkylating agent R-LG, and eluting with an appropriate eluent. Intermediate 31,3-difluoro-5-(methylsulfonyl)benzene; MS (EI) m/z 192.
According to the analysis of related databases, 210532-25-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Bernotas, Ronald Charles; Ullrich, John William; Travins, Jeremy Mark; Wrobel, Jay Edward; Unwalla, Rayomand Jal; US2010/273816; (2010); A1;,
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