Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 102-49-8, name is 3,4-Dichlorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3,4-Dichlorobenzylamine
tert-butyl(2-(N-cyclohexylacrylamido)ethyl)(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)carbamate (100 mg, 0.205 mmol) and (3,4-dichlorophenyl)methanamine (72 mg, 0.41 mmol) were dissolved in ethanol (1 mL) and heated at 50° C. for 20 hours. The solvent was evaporated in vacuo and the residue dissolved in dichloromethane (1 mL). Trifluoroacetic acid (1 mL, 13 mmol) was added and the mixture stirred for 2 hours, and then concentrated under reduced pressure. The residue was purified by prep-HPLC with (eluting with acetonitrile and 0.2percent aqueous trifluoroacetic acid) to afford the title compound (125 mg, 0.155 mmol, 76percent yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) delta 10.04-9.98 (m, 1H), 9.94-9.84 (m, 1H), 8.81 (s, 2H), 8.43 (s, 1H), 7.88-7.80 (m, 1H), 7.80-7.72 (m, 1H), 7.56-7.46 (m, 1H), 6.70-6.62 (m, 1H), 6.52-6.41 (m, 1H), 4.57-4.48 (m, 2H), 4.27-4.18 (m, 2H), 3.56-3.41 (m, 1H), 3.17-3.03 (m, 5H), 2.98 (d, J=12.0 Hz, 2H), 2.76 (dq, J=14.9, 6.9 Hz, 4H), 1.82-1.74 (m, 2H), 1.71-1.58 (m, 3H), 1.56-1.17 (m, 4H), 1.15-1.03 (m, 1H). MS (ESI+) 563.3 [M+H]+.
According to the analysis of related databases, 102-49-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AbbVie Inc.; Chiang, Gary G.; Pappano, William N.; Sweis, Ramzi F.; Wang, Zhi; (23 pag.)US2016/31838; (2016); A1;,
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