Application In Synthesis of 2,4-Dichlorobenzoic acid. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers published in 2020, Reprint Addresses Lee, S (corresponding author), Korea Inst Sci & Technol, Brain Sci Inst, Seoul, South Korea.; Kim, E (corresponding author), Ajou Univ, Dept Mol Sci & Technol, Suwon, South Korea.; Babu, KS (corresponding author), Sri Krishnadevaraya Univ, Dept Chem, Anantapur, Andhra Pradesh, India.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.
Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. However, there is a growing demand for novel small-molecule IFN inducer due to tolerance, toxicity, or short duration of action following direct administration of IFNs. In this study, we assessed arylpiperazine (ARP) as a new core skeleton of IFN inducer. To investigate structure-activity relationship, we designed and synthesized a series of ARP analogues and evaluated the ability to stimulate IFN response in THP-1 human monocyte cells. Compound 5i was identified as a potent type I IFN inducer as it significantly increased cytokine secretion and increased expression of various IFN-stimulating genes which are representative biomarkers of type I IFN pathway. Our results suggested a beneficial therapeutic potential of 5i as an anti-viral agent.
About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Chu, Y; Reddy, BRS; Gajulapalli, VPR; Babu, KS; Kim, E; Lee, S or concate me.. Application In Synthesis of 2,4-Dichlorobenzoic acid
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics