I found the field of Pharmacology & Pharmacy very interesting. Saw the article The Triazole Ring as a Privileged Scaffold for Putative Antifungals: Synthesis and Evaluation of a Series of New Analogues published in 2021. Recommanded Product: 2,4-Dichlorobenzoic acid, Reprint Addresses Zoidis, G (corresponding author), Natl & Kapodistrian Univ Athens, Dept Pharm, Athens 15771, Greece.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid
The significant antifungal activity of a series of novel 1,2,4-triazole derivatives against different strains ofCandida albicans,Candida kruseiandAspergillus fumigatus, compared to the commercial fungicides ketoconazole and itraconazole, is reported. Systemic mycosis and invasive fungal infections, whether from immunodeficiency or hospital-acquired infection, have been on an upward trend for several years. The 1,2,4-triazole ring substituted with other aromatic and heteroaromatic systems plays an important role in the field of antifungal drug discovery and development. Thus, an extensive series of 29 triazoles, substituted in different positions with a variety of aromatic rings, has been designed, synthesized, and evaluated for their fungicidal activity. Almost all the agents testedin vitroshowed high activity against all examined fungal strains. It is noteworthy that, in the case ofA. fumigatus, all the examined compounds achieved equal or higher antifungal activity than ketoconazole, but less activity than itraconazole. Among all the derivatives studied, the dichlorourea analogue and bromo-substituted triazole stand out as the most promising compounds. Quantitative structure-activity relationship (QSAR) models were built for a systematic structure-activity relationship (SAR) profile to explain and potentially explore the potency characteristics of 1,2,4-triazole analogues.
Recommanded Product: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zoidis, G; Kritsi, E; Lecinska, P; Ivanov, M; Zoumpoulakis, P; Sokovic, M; Catto, M or concate me.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics