Month: October 2021

Recommanded Product: 1-Chloro-2-methylbenzene. Recently I am researching about C-H BONDS; BENZOIC-ACID; MOLECULAR-OXYGEN; N-HYDROXYPHTHALIMIDE; SELECTIVE OXIDATION; METAL-FREE; PHOTOOXIDATION; DERIVATIVES; COBALT; OXIDE, Saw an article supported by the National Key Research and Development Program of China [2017YFC0210900]. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Zheng, K; Yan, XY; Zhang, GF; Yan, XH; Li, XQ; Xu, XS. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene

A mild and metal-free procedure is reported for the aerobic oxidation of substituted toluenes to carboxylic acids by using CBr (4) as initiator under irradiation from a 400 nm blue light-emitting diode.

Recommanded Product: 1-Chloro-2-methylbenzene. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Zheng, K; Yan, XY; Zhang, GF; Yan, XH; Li, XQ; Xu, XS or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Noninterruptive Clinical Decision Support Decreases Ordering of Respiratory Viral Panels during Influenza Season WOS:000531597900002 published article about POLYMERASE-CHAIN-REACTION; RESOURCE UTILIZATION; IMPACT; MANAGEMENT; INFECTIONS; PATHOGENS; DIAGNOSIS; OUTCOMES; UTILITY; CARE in [Escovedo, Cameron; Lerner, Carlos] Univ Calif Los Angeles, Dept Pediat, 10833 Le Conte Ave 12-358 MDCC, Los Angeles, CA 90095 USA; [Bell, Douglas] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA; [Cheng, Eric] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA; [Garner, Omai; Ziman, Alyssa] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA USA; [Vangala, Sitaram] Univ Calif Los Angeles, Dept Med Stat Core, Los Angeles, CA USA; [Gounder, Prabhu] Cty Los Angeles Publ Hlth, Acute Communicable Dis Control, Los Angeles, CA USA in 2020.0, Cited 29.0. COA of Formula: C7H4Cl2O2. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6

Objective A growing body of evidence suggests that testing for influenza virus alone is more appropriate than multiplex respiratory viral panel (RVP) testing for general populations of patients with respiratory tract infections. We aimed to decrease the proportion of RVPs out of total respiratory viral testing ordered during influenza season. Methods We implemented two consecutive interventions: reflex testing for RVPs only after a negative influenza test, and noninterruptive clinical decision support (CDS) including modifications of the computerized physician order entry search behavior and cost display. We conducted an interrupted time series of RVPs and influenza polymerase chain reaction tests pre- and postintervention, and performed a mixed-effects logistic regression analysis with a primary outcome of proportion of RVPs out of total respiratory viral tests. The primary predictor was the intervention period, and covariates included the provider, clinical setting, associated diagnoses, and influenza incidence. Results From March 2013 to April 2019, there were 24,294 RVPs and 26,012 influenza tests ( n = 50,306). Odds of ordering an RVP decreased during the reflex testing period (odds ratio: 0.432, 95% confidence interval: 0.397-0.469), and decreased more dramatically during the noninterruptive CDS period (odds ratio: 0.291, 95% confidence interval: 0.259-0.327). Discussion The odds of ordering an RVP were 71% less with the noninterruptive CDS intervention, which projected 4,773 fewer RVPs compared with baseline. Assuming a cost equal to Medicare reimbursement rates for RVPs and influenza tests, this would generate an estimated averted cost of $1,259,474 per year. Conclusion Noninterruptive CDS interventions are effective in reducing unnecessary and expensive testing, and avoid typical pitfalls such as alert fatigue.

About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Escovedo, C; Bell, D; Cheng, E; Garner, O; Ziman, A; Vangala, S; Gounder, P; Lerner, C or concate me.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recently I am researching about DERIVATIVES; BENZOTHIAZOLE; 2-MERCAPTO; DESIGN, Saw an article supported by the PHENIKAA University [01.2020.05]. Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Tung, TT; Huy, LX. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline. Computed Properties of C7H8ClN

A simple, efficient, and metal-free methodology for the preparation of 2-mercaptobenzothiazole and derivatives in excellent yields via microwave-assisted pathway is reported. Our condition provides a convenient protocol for the synthesis of a diverse collection of 2-mercaptobenzothiazoles and 6-(4-substituted-1H-1,2,3-triazol-1-yl)-2-mercaptobenzothiazoles with a very simple purification process. This report provides an alternative protocol for fast access to the wide range of compounds for sequence synthesis and biological studies.

About 2-Chloro-6-methylaniline, If you have any questions, you can contact Tung, TT; Huy, LX or concate me.. Computed Properties of C7H8ClN

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

I found the field of Science & Technology – Other Topics; Energy & Fuels very interesting. Saw the article Study on the influence of small molecular gases on toluene reforming in molten salt published in 2020.0. Safety of 1-Chloro-2-methylbenzene, Reprint Addresses Hu, HY (corresponding author), Huazhong Univ Sci & Technol, Sch Energy & Power Engn, State Key Lab Coal Combust, Wuhan 430074, Peoples R China.. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene

The upgrading of tar is a key issue for the sufficient application of biowaste pyrolysis technology. Molten salt, with high migration and diffusion of ions to prevent the deactivation of coke deposition of tar reforming functional metals, is considered as a feasible catalytic reaction medium and heat carrier for the upgrading of tar. The present study investigated the interactions between small molecular pyrolysis gases (including H-2, CO, CH4) and main tar model compound in ternary carbonate eutectics (Li2CO3-Na2CO3-K2CO3). The results demonstrated that H-2 could be decomposed to produce H radicals, promoting the conversion of toluene into gaseous products. CO32- could consume H radicals required by toluene cracking, making the process toluene polymerized to polycyclic aromatic hydrocarbons be strengthened. On the other hand, CO would react with OH radicals to produce H radicals and could enhance gas-generating process. In addition, toluene could react with CO to form benzaldehyde and phenylacetaldehyde. With the addition of CH4, more H radicals were supposed to be consumed, and toluene cracking process was further inhibited. Finally, the effect sequence of small molecular gases (H-2 > CH4 > CO) on toluene reforming reaction was authenticated by investigating the impacts of introducing any two gases in toluene reforming. (C) 2020 Elsevier Ltd. All rights reserved.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Yang, F; Hu, HY; Gao, Q; Yang, YH; Tang, H; Xie, K; Liu, H; He, Y; Yao, H or concate me.. Safety of 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Bis-salophen palladium complex immobilized on Fe3O4@SiO2 nanoparticles as a highly active and durable phosphine-free catalyst for Heck and copper-free Sonogashira coupling reactions WOS:000460780300033 published article about SCHIFF-BASE COMPLEX; SUZUKI-MIYAURA; MAGNETIC NANOPARTICLES; SUPPORTED-PALLADIUM; HETEROGENEOUS CATALYST; FE3O4 NANOPARTICLES; EFFICIENT CATALYST; MIZOROKI-HECK; 5-SUBSTITUTED 1H-TETRAZOLES; RECOVERABLE CATALYSTS in [Sardarian, Ali Reza; Kazemnejadi, Milad; Esmaeilpour, Mohsen] Shiraz Univ, Dept Chem, Coll Sci, Shiraz 7194684795, Iran in 2019.0, Cited 72.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. HPLC of Formula: C7H7Cl

New Fe3O4@SiO2 core-shell superparamagnetic nanoparticles functionalized by a bis-salophen Schiff base Pd complex were synthesized and employed as an efficient magnetic nanocatalyst in the Heck and Sonogashira cross coupling reactions. The synthesized nanostructures were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), dynamic light scattering (DLS), energy dispersive X-ray analysis (EDX), X-ray photoelectron spectroscopy (XPS), elemental analysis (CHN), cyclic voltammetry (CV), Brunauer-Emmett-Teller analysis (BET), and UV-vis spectroscopy. The morphology and size of the nanoparticles were investigated by FE-SEM and TEM analyses. Furthermore, the magnetic properties of the catalyst were investigated by VSM analysis. The loading content and leaching amounts of palladium on the catalyst were measured by inductively coupled plasma (ICP) analysis. Also, the thermal behavior of this magnetic heterogeneous catalyst was studied using a TGA instrument. This heterogeneous catalytic system showed a good performance in the coupling of aryl halides with alkynes (Sonogashira reaction) as well as aryl halides with alkene derivatives (Heck reaction). High to excellent yields were achieved for these C-C coupling reactions. The catalyst can be simply separated from the reaction media by an external magnet and reused for eight consecutive runs without any significant loss of activity. Finally, the kinetics of the reactions were studied in this work.

HPLC of Formula: C7H7Cl. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Sardarian, AR; Kazemnejadi, M; Esmaeilpour, M or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: 2-Chloro-6-methylaniline. Recently I am researching about I PI3 KINASE; INHIBITORS; IDENTIFICATION; SAR; THIENOPYRIMIDINE; DISCOVERY, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573296]; LiaoNing Revitalization Talents Program [XLYC1808037]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Ye, TY; Han, YF; Wang, RX; Yan, PZ; Chen, SW; Hou, YL; Zhao, YF. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline

To develop novel therapeutic agents with anticancer activities, two series of novel 2,4-bismorpholinyl-thieno [3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives were designed, synthesized and evaluated for their biological activities. Among them, compound A(12) showed the most potent antitumor activities against HCT116, PC-3, MCF-7, A549 and MDA-MB-231 cell lines with IC50 values of 3.24 mu M, 14.37 mu M, 7.39 mu M, 7.10 mu M, and 16.85 mu M, respectively. Further explorations in bioactivity were conducted to clarify the anticancer mechanism of compound A(12). The results showed that compound A(12) obviously inhibited the proliferation of A549 cell lines and decreased mitochondrial membrane potential, which led to the apoptosis of cancer cells and suppressed the migration of tumor cells.

About 2-Chloro-6-methylaniline, If you have any questions, you can contact Ye, TY; Han, YF; Wang, RX; Yan, PZ; Chen, SW; Hou, YL; Zhao, YF or concate me.. Name: 2-Chloro-6-methylaniline

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Ligand-Facilitated Reductive Coupling of Benzyl Chlorides with Aryl Chlorides Catalyzed by Well-Defined Heteroleptic Ni (II)-NHC Complexes published in 2020.0. HPLC of Formula: C7H7Cl, Reprint Addresses Sun, HM (corresponding author), Soochow Univ, Coll Chem Chem Engn & Mat, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China.. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene

Novel heteroleptic Ni (II) complexes bearing a highly hindered yet flexible IPr* ligand, Ni (IPr*)(PPh3)Br-2 (1) and Ni (IPr*)(PCy3)Br-2 (2) (IPr* = 1,3-bis(2,6-bis (diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene), were easily prepared in 78% and 89% yield, respectively. Both were characterized by elemental analysis and NMR spectroscopy, and 1 was subjected to X-ray crystallography. Compared with 2 and its analogue bearing a less sterically demanding IPr ligand (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), complex 1 exhibited superior catalytic activity in the magnesium-mediated reductive coupling of benzyl chlorides with aryl chlorides, featuring outstanding tolerance of both coupling partners with steric demand. This study discloses a ligand-facilitated reductive coupling of benzyl chlorides with aryl chlorides, which provides a new and practical synthetic tool for the synthesis of diarylmethanes.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Lu, GS; Li, RP; Shen, ZW; Wu, QJ; Sun, HM or concate me.. HPLC of Formula: C7H7Cl

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recently I am researching about HETEROCYCLIC CARBENE LIGANDS; C-N; NICKEL; CATALYSIS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21971183]; Natural Science Foundation of the Jiangsu Higher Education Institutions of ChinaNational Natural Science Foundation of China (NSFC) [19KJA610001]; Key Laboratory of Organic Chemistry of Jiangsu Province. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Shen, ZW; Meng, DD; Imran, S; Yan, CH; Sun, HM. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene. Application In Synthesis of 1-Chloro-2-methylbenzene

A bisoxazoline-derived NHC known as IBiox-6 reacted smoothly with Ni[P(OEt)(3)](2)Br-2 and Ni(PPh3)(2)Br-2 to give the respective heteroleptic Ni(II) complexes Ni(IBiox-6)[P(OEt)(3)]Br-2 (1) and Ni(IBiox-6)(PPh3)Br-2 (2) in yields of 60% and 71%. Their crystal structures were characterized to reveal a rare cis disposition of the IBiox-6 ligand to the phosphite ligand in 1, while 2 possessed the more common trans configuration. Both complexes catalyzed the cross-electrophile coupling of benzyl chlorides with aryl chlorides and fluorides in the presence of Mg turnings at 50 degrees C via a real one-pot procedure, featuring no requirement for temperature variation or portionwise addition of any coupling partner. In particular, complex 1 showed a better balance between the catalytic activity and selectivity. The scope of the procedure catalyzed by 1 and Mg turnings was investigated, providing a highly selective, simple, and practical approach to the synthesis of diarylmethanes with high steric hindrance and various functional groups, including oligo-diarylmethane with asymmetric structures.

Application In Synthesis of 1-Chloro-2-methylbenzene. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Shen, ZW; Meng, DD; Imran, S; Yan, CH; Sun, HM or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recently I am researching about CELL LUNG-CANCER; IRREVERSIBLE INHIBITORS; FAMILY KINASES; DISCOVERY; GROWTH; RESISTANCE; PROTEIN; OPTIMIZATION; ACTIVATION; EXPRESSION, Saw an article supported by the WelchThe Welch Foundation [I-1829]; ACSAmerican Cancer Society [RSG-18-039-01-DMC]; Career Enhancement Grant through NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [P50CA07090720]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Du, GY; Rao, SM; Gurbani, D; Henning, NJ; Jiang, J; Che, JW; Yang, A; Ficarro, SB; Marto, JA; Aguirre, AJ; Sorger, PK; Westover, KD; Zhang, TH; Gray, NS. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline. Safety of 2-Chloro-6-methylaniline

SRC is a major regulator of many signaling pathways and contributes to cancer development. However, development of a selective SRC inhibitor has been challenging, and FDA-approved SRC inhibitors, dasatinib and bosutinib, are multitargeted kinase inhibitors. Here, we describe our efforts to develop a selective SRC covalent inhibitor by targeting cysteine 277 on the P-loop of SRC. Using a promiscuous covalent kinase inhibitor (CKI) SM1-71 as a starting point, we developed covalent inhibitor 15a, which discriminates SRC from other covalent targets of SM1-71 including TAK1 and FGFR1. As an irreversible covalent inhibitor, compound 15a exhibited sustained inhibition of SRC signaling both in vitro and in vivo. Moreover, 15a exhibited potent antiproliferative effects in nonsmall cell lung cancer cell lines harboring SRC activation, thus providing evidence that this approach may be promising for further drug development efforts.

About 2-Chloro-6-methylaniline, If you have any questions, you can contact Du, GY; Rao, SM; Gurbani, D; Henning, NJ; Jiang, J; Che, JW; Yang, A; Ficarro, SB; Marto, JA; Aguirre, AJ; Sorger, PK; Westover, KD; Zhang, TH; Gray, NS or concate me.. Safety of 2-Chloro-6-methylaniline

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recently I am researching about CYCLOPENTYL METHYL-ETHER; CROSS-COUPLING REACTIONS; RING-CLOSING METATHESIS; STEREOCONTROLLED SYNTHESIS; ALCOHOLS; REAGENTS; REARRANGEMENT; OXIDATION; ALDEHYDES; EFFICIENT, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP17K07779]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Kobayashi, S; Tamura, T; Yoshimoto, S; Kawakami, T; Masuyama, A. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene. Category: chlorides-buliding-blocks

4-Methyltetrahydropyran (4-MeTHP) is a hydrophobic cyclic ether with potential for industrial applications. We herein report, for the first time, a comprehensive study on the performance of 4-MeTHP as an organic reaction solvent. Its broad application to organic reactions includes radical, Grignard, Wittig, organometallic, halogen-metal exchange, reduction, oxidation, epoxidation, amidation, esterification, metathesis, and other miscellaneous organic reactions. This breadth suggests 4-MeTHP can serve as a substitute for conventional ethers and harmful halogenated solvents. However, 4-MeTHP was found incompatible with strong Lewis acids, and the C-O bond was readily cleaved by treatment with BBr3. Moreover, the radical-based degradation pathways of 4-MeTHP, THP and 2-MeTHF were elucidated on the basis of GC-MS analyses. The data reported herein is anticipated to be useful for a broad range of synthetic chemists, especially industrial process chemists, when selecting the reaction solvent with green chemistry perspectives.

Category: chlorides-buliding-blocks. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Kobayashi, S; Tamura, T; Yoshimoto, S; Kawakami, T; Masuyama, A or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics