Month: October 2021

Formula: C7H4Cl2O2. Cox, B; Duffy, J; Zdorichenko, V; Bellanger, C; Hurcum, J; Laleu, B; Booker-Milburn, KI; Elliott, LD; Robertson-Ralph, M; Swain, CJ; Bishop, SJ; Hallyburton, I; Anderson, M in [Duffy, James; Laleu, Benoit] Med Malaria Venture, CH-1215 Geneva 15, Switzerland; [Cox, Brian; Zdorichenko, Victor; Bellanger, Corentin; Bishop, Stephen J.] Univ Sussex, Photodivers Ltd, Sch Life Sci, Brighton BN1 9QJ, E Sussex, England; [Hurcum, Jessica] Univ Sussex, Sch Life Sci, Brighton BN1 9QJ, E Sussex, England; [Booker-Milburn, Kevin, I; Elliott, Luke D.] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England; [Booker-Milburn, Kevin, I; Robertson-Ralph, Michael] Univ Bristol, Sch Chem, Photodivers Ltd, Bristol BS8 1TS, Avon, England; [Swain, Christopher J.] Cambridge MedChem Consulting, Cambridge CB22 4RN, England; [Hallyburton, Irene; Anderson, Mark] Univ Dundee, Wellcome Ctr Antiinfect Res, Drug Discovery Unit, Dundee DD1 5EH, Scotland published Escaping from Flatland: Antimalarial Activity of sp(3)-Rich Bridged Pyrrolidine Derivatives in 2020, Cited 18. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

We utilized synthetic photochemistry to generate novel sp 3 -rich scaffolds and report the design, synthesis, and biological testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-azabicyclo[2.1.1]hexane scaffold. Preliminary antimalarial screening of the library provided promising compounds with activity in the 1-5 mu M range with an enhanced hit rate. Further evaluation (solubility, drug metabolism and pharmacokinetics (DMPK), and toxicity) of a selected compound (9) suggested that this series represents an excellent opportunity for further optimization with the framework offering multiple opportunities for the addition of uniquely vectorally positioned extra functionality.

Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Cox, B; Duffy, J; Zdorichenko, V; Bellanger, C; Hurcum, J; Laleu, B; Booker-Milburn, KI; Elliott, LD; Robertson-Ralph, M; Swain, CJ; Bishop, SJ; Hallyburton, I; Anderson, M or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Pollution characteristics of aromatic hydrocarbons in the groundwater of China WOS:000557880300004 published article about VOLATILE ORGANIC-COMPOUNDS; PEARL RIVER DELTA; RISK-ASSESSMENT; DRINKING-WATER; HUMAN-HEALTH; DEGRADATION; BENZENE; AQUIFER; REGION; URBAN in [Zhao, Bei; Huang, Fuyang; Zhang, Chong; Xue, Qiang; Liu, Fei] China Univ Geosci Beijing, MOE Key Lab Groundwater Circulat & Environm Evolu, Beijing 100083, Peoples R China; [Zhao, Bei; Huang, Fuyang; Zhang, Chong; Xue, Qiang; Liu, Fei] China Univ Geosci Beijing, Beijing Key Lab Water Resources & Environm Engn, Beijing 100083, Peoples R China; [Huang, Guoxin] Chinese Acad Environm Planning, Beijing 100012, Peoples R China in 2020.0, Cited 64.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. Application In Synthesis of 1-Chloro-2-methylbenzene

Much of the worlds groundwater supply has been contaminated by aromatic hydrocarbons originating from anthropogenic sources. To study the occurrence and distribution characteristics of aromatic hydrocarbons in groundwater, 24 aromatic hydrocarbon compounds were selected: Five BTEX compounds (benzene, toluene, ethylbenzene, o-xylene, m-xylene, and p-xylene), 10 alkyl-substituted benzene, and 9 halogenated aromatics. These aromatic hydrocarbons were then analyzed from 355 samples collected from across China. Results indicated that aromatic hydrocarbons were detected in 59 out of 355 samples. Of the selected aromatic hydrocarbons, BTEX compounds were detected with high frequency and at low concentrations; comparatively, halogenated aromatics were detected with low frequency and at high concentrations. The aromatic hydrocarbon characteristics found in both karst and pore groundwater samples were then determined using their respective hydrogeological conditions and corresponding human activities. In karst groundwater, BTEX compounds were the most frequently detected aromatic hydrocarbon. The high detection frequencies of aromatic hydrocarbons were caused by their rapid migration, owing to the developed conduit system in the sampled karst area. The low concentrations of aromatic hydrocarbons in karst groundwater samples were caused by low-intensity human activity along with special hydrogeological conditions with higher redox potential and the unique compositions of aromatic hydrocarbons. Alkyl-substituted aromatics and halogenated aromatics were detected at higher concentrations in pore groundwater, owing to high-intensity human activity. Aromatic hydrocarbon pollution was gradually decreased along piedmont-alluvial plain-coast line, owing to a decrease in aquifer vulnerability. These were positively correlated with the size of the aquifer’s particles. Samples with a high accumulative concentration of these aromatic hydrocarbons tended to occur in pore groundwater with a high concentration of either SO42- or Cl-.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Zhao, B; Huang, FY; Zhang, C; Huang, GX; Xue, Q; Liu, F or concate me.. Application In Synthesis of 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Glycosyl triazoles as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors: Design, synthesis, molecular docking and MD simulations WOS:000468879400006 published article about ACETYL-D-HEXOSAMINIDASE; NAG-THIAZOLINE; DERIVATIVES; DYNAMICS; INSIGHTS in [Dong, Lili; Shen, Shengqiang; Lu, Huizhe; Xu, Dongdong; Jin, Shuhui; Zhang, Jianjun] China Agr Univ, Coll Sci, Dept Appl Chem, Beijing, Peoples R China; [Chen, Wei; Yang, Qing] Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, Inst Plant Protect, Beijing 100193, Peoples R China in 2019.0, Cited 36.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6. Application In Synthesis of 2,6-Dichlorobenzoic acid

The insect enzyme GH20 beta-N-acetyl-D-hexosaminidase OfHex1 represents an important chitinolytic enzyme found in the agricultural pest Ostrinia furnacalis (Guenee) and inhibition of this enzyme has been considered a promising strategy for the development of eco-friendly pesticides. In this article, based on the structure of the catalytic domains of OfHex1, a series of novel glycosyl triazoles were designed and synthesized via Cu-catalyzed azide-alkyne [3+ 2] cycloaddition reaction. To investigate the potency and selectivity of these glycosyl triazoles, the inhibition activities towards OfHex1 and HsHexB (human beta-N-acetylhexosaminidase B) were studied. Particularly compound 17c (OfHex1, K-i= 28.68 mu M; HsHexB, K-i > 100 mu M) exhibited a suitable activity and selectivity against OfHex1. Furthermore, the possible inhibitory mechanisms of 17c with OfHex1 were studied using molecular docking and MD simulations. The structure-activity relationship results as well as the formed binding patterns may provide promising insights into the further development of novel OfHex1 inhibitors.

About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Dong, LL; Shen, SQ; Chen, W; Lu, HZ; Xu, DD; Jin, SH; Yang, Q; Zhang, JJ or concate me.. Application In Synthesis of 2,6-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2020.0 ORG LETT published article about PALLADIUM-CATALYZED AMINATION; RAPID CONSTRUCTION; LIGANDS; ARYL; COMPLEXES; ARYLATION in [Zhang, Zhuan; Cordier, Marie; Dixneuf, Pierre H.; Soule, Jean-Francois] Univ Rennes, CNRS, ISCR UMR 6226, F-35000 Rennes, France in 2020.0, Cited 33.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. Recommanded Product: 1-Chloro-2-methylbenzene

We report herein P(III)-directed C-H bond alkenylation of (dialkyl)- and (diaryl)biarylphosphines using internal alkynes. Chloride-free [Rh(OAc)(COD)](2) acts as a better catalyst than commercially available [RhCl(COD)](2). Conditions were developed to control the mono- and difunctionalization depending on the alkyne stoichiometry. One of these novel bisalkenylated (dialkyl)biarylphosphines was employed for the preparation of a palladium(II) complex, and some of these functionalized ligands outperformed their corresponding unfunctionalized phosphines in Pd-catalyzed amidation with sterically hindered aryl chlorides.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Zhang, Z; Cordier, M; Dixneuf, PH; Soule, JF or concate me.. Recommanded Product: 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 1-Chloro-2-methylbenzene. Recently I am researching about HETEROCYCLIC CARBENE; ALKYL BROMIDES; PRE-CATALYST; NICKEL; HALIDES; ACTIVATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21472134, 21971183]; Natural Science Foundation of the Jiangsu Higher Education Institutions of ChinaNational Natural Science Foundation of China (NSFC) [19KJA610001]. Published in WILEY in HOBOKEN ,Authors: Lu, GS; Li, RP; Shen, ZW; Wu, QJ; Sun, HM. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene

Novel heteroleptic Ni (II) complexes bearing a highly hindered yet flexible IPr* ligand, Ni (IPr*)(PPh3)Br-2 (1) and Ni (IPr*)(PCy3)Br-2 (2) (IPr* = 1,3-bis(2,6-bis (diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene), were easily prepared in 78% and 89% yield, respectively. Both were characterized by elemental analysis and NMR spectroscopy, and 1 was subjected to X-ray crystallography. Compared with 2 and its analogue bearing a less sterically demanding IPr ligand (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), complex 1 exhibited superior catalytic activity in the magnesium-mediated reductive coupling of benzyl chlorides with aryl chlorides, featuring outstanding tolerance of both coupling partners with steric demand. This study discloses a ligand-facilitated reductive coupling of benzyl chlorides with aryl chlorides, which provides a new and practical synthetic tool for the synthesis of diarylmethanes.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Lu, GS; Li, RP; Shen, ZW; Wu, QJ; Sun, HM or concate me.. Recommanded Product: 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Authors Xi, Y; Yang, XH; Zhang, HY; Liu, HH; Watson, P; Yang, FF in PERGAMON-ELSEVIER SCIENCE LTD published article about POLYBROMINATED DIPHENYL ETHERS; ENDOCRINE-DISRUPTING ACTIVITY; HORMONE TRANSPORT PROTEINS; AROMATIC HALOGENATED DBPS; IN-VITRO; PARTITION-COEFFICIENTS; CHEMICALS; PREDICTION; MODELS; CLASSIFICATION in [Xi, Yue; Yang, Xianhai; Zhang, Hongyu; Liu, Huihui] Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, Jiangsu Key Lab Chem Pollut Control & Resources R, Nanjing 210094, Peoples R China; [Watson, Peter; Yang, Feifei] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06268 USA in 2020, Cited 75. COA of Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

The anionic form-dependent binding interaction of halo-phenolic substances with human transthyretin (hTTR) has been observed previously. This indicates that ionizable compounds should be the primary focus in screening potential hTTR disruptors. Here, the potential binding potency of halo-benzoic acids, halo-benzenesulfonic acids/sulfates and halo-phenylboronic acids with hTTR was determined and analyzed by competitive fluorescence displacement assay integrated with computational methods. The laboratorial results indicated that the three test groups of model compounds exhibited a distinct binding affinity to hTTR. All the tested halo-phenylboronic acids, some of the tested halo-benzoic acids and halo-benzenesulfonic acids/sulfates were shown to be inactive with hTTR Other halo-benzoic acids and halo-benzenesulfonic acids/sulfates were moderate and/or weak hTTR binders. The binding affinity of halo-benzoic acids and halo-benzenesulfonic acids/sulfates with hTTR was similar. The low distribution ability of the model compounds from water to hTTR may be the reason why they exhibited the binding potency observed with hTTR. By introducing other highly hydrophobic compounds, we observed that the binding affinity between compounds and hTTR increased with increasing molecular hydrophobicity. Those results indicated that the highly hydrophobic halo-benzoic acids and halo-benzenesulfonic acids/sulfates may be high-priority hTTR disruptors. Finally, a binary classification model was constructed employing three predictive variables. The sensitivity (S-n), specificity (S-p), predictive accuracy (Q) values of the training set and validation set were >0.83, indicating that the model had good classification performance. Thus, the binary classification model developed here could be used to distinguish whether a given ionizable compound is a potential hTTR binder or not. (C) 2019 Elsevier Ltd. All rights reserved.

COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Xi, Y; Yang, XH; Zhang, HY; Liu, HH; Watson, P; Yang, FF or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: C7H8ClN. I found the field of Chemistry very interesting. Saw the article Efficient synthesis of 2-aryl-2H-indazoles by base-catalyzed benzyl C-H deprotonation and cyclization published in 2020, Reprint Addresses Zhou, YB; Liu, MC (corresponding author), Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China.. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline.

A straightforward and efficient method for the preparation of 2-aryl-2H-indazoles from ortho-alkyl substituted azoxybenzenes is presented. The reaction proceeds through base-catalyzed benzyl C-H deprotonation and cyclization to afford 2-aryl-2H-indazoles in good yields. This synthetic strategy can be applied to the construction of several fluorescent and bioactive molecules.

HPLC of Formula: C7H8ClN. About 2-Chloro-6-methylaniline, If you have any questions, you can contact Jin, GQ; Gao, WX; Zhou, YB; Liu, MC; Wu, HY or concate me.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Efficient synthesis of 2-aryl-2H-indazoles by base-catalyzed benzyl C-H deprotonation and cyclization published in 2020. HPLC of Formula: C7H8ClN, Reprint Addresses Zhou, YB; Liu, MC (corresponding author), Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China.. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline

A straightforward and efficient method for the preparation of 2-aryl-2H-indazoles from ortho-alkyl substituted azoxybenzenes is presented. The reaction proceeds through base-catalyzed benzyl C-H deprotonation and cyclization to afford 2-aryl-2H-indazoles in good yields. This synthetic strategy can be applied to the construction of several fluorescent and bioactive molecules.

HPLC of Formula: C7H8ClN. About 2-Chloro-6-methylaniline, If you have any questions, you can contact Jin, GQ; Gao, WX; Zhou, YB; Liu, MC; Wu, HY or concate me.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Acylation of 25-hydroxyprotopanaxatriol with aromatic acids increases cytotoxicity published in 2019. Name: 2,4-Dichlorobenzoic acid, Reprint Addresses Piao, HR (corresponding author), Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Coll Pharm, Yanji 133002, Peoples R China.; Zhao, YQ (corresponding author), Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang, Liaoning, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

20(R)-25-hydroxyprotopanaxadiol (25-OH-PPD) is a natural compound showing a variety of anti-tumor effects. In an attempt to search for a new anti-cancer compound with higher antitumor activities, we designed and synthesized a series of 25-OH-PPD derivatives. Cytotoxicity assay of these derivatives towards MCF-7, A549, U87, HO-8901, Hela cancer cell lines and normal IOSE144 cell lines were tested by MTF assay. Results showed that compared with compound 25-OH-PPD, Compounds 4, 5, 6, 10, 11 showed strong anticancer activity, and all compounds showed low toxicity or no toxicity for normal cells. In particular, compound 6 exhibited the best anti-tumor activity in all cancer cell lines (MCF-7, A549, U87, HO-8901, and Hela) with IC50 values of 5.04 mu M, 1.36 mu M, 3.24 mu M, 3.47 mu M, 4.57 mu M, respectively. Among the five cell lines, all the compounds showed strong inhibition on A549 cells. Further studies showed that Compound 6 significantly inhibited the proliferation of A549 cells by inducing apoptosis. Our results indicate that Compound 6 is a potential anticancer inhibitor and provides a theoretical basis for further research.

Name: 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Lv, LY; Lu, JC; Zhang, HY; Wang, XD; Su, GY; Piao, HR; Zhao, YQ or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 1-Chloro-2-methylbenzene. I found the field of Chemistry very interesting. Saw the article Switchable Bifunctional Bistate Reusable ZnO-Cu for Selective Oxidation and Reduction Reaction published in 2019.0, Reprint Addresses Pratihar, S (corresponding author), Tezpur Univ, Dept Chem Sci, Napaam 784028, Assam, India.. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene.

Herein we disclosed the utilization of copper loaded zinc oxide (ZnO-Cu) for its stimuli (O-2/light) responsive switchable performance between its reduced (S-1) and oxidized (S-2) state for two antagonistic reactions, namely oxidation of alkyl arenes/heteroarenes to aldehydes/ketones and reduction of nitro arenes/heteroarenes corresponding amines. The two states of the catalyst showed its switchable performance as highly active and poorly active catalyst for oxidation and reduction, and both reactions could be turned off and on by changing the stimuli (light and O-2/N-2). The switching efficiency between the states and their relative reactivity were found to be consistent under variety of reaction conditions and remain unaltered irrespective of oxidation-reduction (or vice versa) sequence and substrates used in the reaction. The photo catalysts (S-1 and S-2) demonstrated good catalytic activity, multiple reusability, broad substrate scope, and reasonable functional group tolerance for both the reactions and probed its quality performance in a large-scale setup. The system was used in an assisted tandem catalysis setup for the synthesis of benzyl amines utilizing both oxidation and reduction reaction by stimuli responsive switching between the states of the catalyst.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Sarmah, K; Mukhopadhyay, S; Maji, TK; Pratihar, S or concate me.. Safety of 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics