Month: October 2021

In 2020.0 ORGANOMETALLICS published article about HETEROCYCLIC CARBENE LIGANDS; C-N; NICKEL; CATALYSIS in [Shen, Zheng-Wang; Meng, Die-Die; Imran, Sajid; Sun, Hong-Mei] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Jiangsu, Peoples R China; [Yan, Chun-Hui] Soochow Univ, Anal & Testing Ctr, Suzhou 215123, Jiangsu, Peoples R China in 2020.0, Cited 37.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. Recommanded Product: 1-Chloro-2-methylbenzene

A bisoxazoline-derived NHC known as IBiox-6 reacted smoothly with Ni[P(OEt)(3)](2)Br-2 and Ni(PPh3)(2)Br-2 to give the respective heteroleptic Ni(II) complexes Ni(IBiox-6)[P(OEt)(3)]Br-2 (1) and Ni(IBiox-6)(PPh3)Br-2 (2) in yields of 60% and 71%. Their crystal structures were characterized to reveal a rare cis disposition of the IBiox-6 ligand to the phosphite ligand in 1, while 2 possessed the more common trans configuration. Both complexes catalyzed the cross-electrophile coupling of benzyl chlorides with aryl chlorides and fluorides in the presence of Mg turnings at 50 degrees C via a real one-pot procedure, featuring no requirement for temperature variation or portionwise addition of any coupling partner. In particular, complex 1 showed a better balance between the catalytic activity and selectivity. The scope of the procedure catalyzed by 1 and Mg turnings was investigated, providing a highly selective, simple, and practical approach to the synthesis of diarylmethanes with high steric hindrance and various functional groups, including oligo-diarylmethane with asymmetric structures.

Recommanded Product: 1-Chloro-2-methylbenzene. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Shen, ZW; Meng, DD; Imran, S; Yan, CH; Sun, HM or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Biopsy rate and nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD) WOS:000542449900001 published article about FIBROSIS; MANAGEMENT; ASSOCIATION; VALIDATION; SYSTEM; SCORE; EASD in [Gerhardt, Florian; Blank, Valentin; Boehlig, Albrecht; van Boemmel, Florian; Berg, Thomas; Karlas, Thomas; Wiegand, Johannes] Univ Hosp Leipzig, Clin & Polyclin Oncol Gastroenterol Hepatol Pneum, Liebigstr 20, D-04103 Leipzig, Germany; [Petroff, David] Univ Leipzig, Clin Trial Ctr Leipzig, Leipzig, Germany; [Blank, Valentin] Univ Leipzig, Integrated Res & Treatment Ctr Adipos Dis, Leipzig, Germany; [Wittekind, Christian] Univ Hosp Leipzig, Inst Pathol, Leipzig, Germany in 2020, Cited 30. SDS of cas: 87-63-8. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

Background:Licensed therapies for nonalcoholic fatty liver disease (NAFLD) do not yet exist, but clinical trials are testing treatment options. Inclusion criteria often require liver biopsy showing fibrosis (F2/3) or cirrhosis (F4) and nonalcoholic steatohepatitis (NASH). However, histological criteria pose a serious obstacle for recruitment. Aims:Characterize the relevance of liver biopsies in the selection of patients with NAFLD. Methods:Patients between 2013 and 2018 with the ICD-10 code K76.0 were analyzed. Fibrosis was defined by the NASH clinical research network (CRN) fibrosis staging system, NASH by a NAFLD activity score (NAS) >= 4. Predictive factors were determined by logistic regression. Results:Liver biopsy was performed in 87/638 (13.6%) patients (49% female, age 52.5 +/- 14.0, BMI 30.4 +/- 5.9 kg/m(2)). Fibrosis stage F0/F1/F2/F3/F4 was observed inN = 7/47/7/17/9, an NAS >= 4 inN = 27. Fibrosis stage F2/F3 and F4 along with NAS >= 4 was found in 1.7% and 0.5% of cases. Liver stiffness measurement, LSM (OR 2.3 per doubling of value; CI 1.3-4.4,p = .005) and FIB-4 (OR 2.3 per doubling of value; CI 1.2-4.4,p = .012) were significant predictors for fibrosis >= F2. Predictive factors for NASH were not identified. Conclusion:The biopsy rate in NAFLD patients is low and fibrosis >= F2 along with NAS >= 4 only present in a few cases. Transient elastography and FIB-4 are useful to select patients at risk for fibrosis for liver biopsy.

About 2-Chloro-6-methylaniline, If you have any questions, you can contact Gerhardt, F; Petroff, D; Blank, V; Bohlig, A; van Bommel, F; Wittekind, C; Berg, T; Karlas, T; Wiegand, J or concate me.. SDS of cas: 87-63-8

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2020 BIOORG CHEM published article about I PI3 KINASE; INHIBITORS; IDENTIFICATION; SAR; THIENOPYRIMIDINE; DISCOVERY in [Ye, Tianyu; Han, Yufei; Wang, Ruxin; Yan, Pingzhen; Chen, Shaowei; Hou, Yunlei; Zhao, Yanfang] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wenhua Rd, Shenyang 110016, Peoples R China in 2020, Cited 30. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8. Category: chlorides-buliding-blocks

To develop novel therapeutic agents with anticancer activities, two series of novel 2,4-bismorpholinyl-thieno [3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives were designed, synthesized and evaluated for their biological activities. Among them, compound A(12) showed the most potent antitumor activities against HCT116, PC-3, MCF-7, A549 and MDA-MB-231 cell lines with IC50 values of 3.24 mu M, 14.37 mu M, 7.39 mu M, 7.10 mu M, and 16.85 mu M, respectively. Further explorations in bioactivity were conducted to clarify the anticancer mechanism of compound A(12). The results showed that compound A(12) obviously inhibited the proliferation of A549 cell lines and decreased mitochondrial membrane potential, which led to the apoptosis of cancer cells and suppressed the migration of tumor cells.

About 2-Chloro-6-methylaniline, If you have any questions, you can contact Ye, TY; Han, YF; Wang, RX; Yan, PZ; Chen, SW; Hou, YL; Zhao, YF or concate me.. Category: chlorides-buliding-blocks

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recently I am researching about EFFICIENT; FUNCTIONALIZATION; NANOPARTICLE; HETEROARENES; MECHANISM; ARRAY, Saw an article supported by the JST ACT CJapan Science & Technology Agency (JST) [JPMJCR12ZC]; JST ACCELJapan Science & Technology Agency (JST) [JPMJAC1401]; JSPSMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [24550126, 20655035, 15 K05510]; AMED [19ak0101115 h]; Takeda Science FoundationTakeda Science Foundation (TSF); Naito FoundationNaito Memorial Foundation; RIKEN. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Ohno, A; Sato, T; Mase, T; Uozumi, Y; Yamada, YMA. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene. Product Details of 95-49-8

The development of highly active and reusable supported catalysts for Suzuki-Miyaura coupling and catalytic C-H arylation is important for fundamental and applied chemistry, with these reactions being used to produce medical compounds and functional materials. Herein, we found that a mesoporous composite made of a linear poly(4-vinylpyridine) and tetrachloropalladate acted as a dual-mode catalyst for a variety of cross-coupling reactions, with both Pd nanoparticles and a Pd complex catalyst being observed under different conditions. The polyvinylpyridine-palladium composite1was readily prepared via the molecular convolution of poly(4-vinylpyridine) and sodium tetrachloropalladate to provide a hardly soluble polymer-metal composite. The Suzuki-Miyaura coupling and the C-H arylation of aryl chlorides and bromides with arylboronic acids, thiophenes, furans, benzene, and anisole proceeded in the presence of 0.004 mol% (40 mol ppm) to 1 mol% Pd of1to afford the corresponding coupling products in high yields. Furthermore, the catalyst was reused without an appreciable loss of activity. Pharmaceutical compounds and functional materials were synthesized via the coupling reactions. N(2)gas adsorption/desorption analysis indicated that the catalyst had a mesoporous nature, which played a crucial role in the catalysis. In the Suzuki-Miyaura couplings,in situgenerated palladium nanoparticles in the polymer matrix were catalytically active, while a polymeric Pd(II) complex was crucial in the C-H arylations. These catalytic species were investigated via XAFS, XPS, far-infrared absorption, and Raman spectroscopies, as well as DFT calculations.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Ohno, A; Sato, T; Mase, T; Uozumi, Y; Yamada, YMA or concate me.. Product Details of 95-49-8

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, YH; Sun, LL; Yang, TY; Jiao, WX; Tang, JS; Huang, XM; Huang, ZZ; Meng, Y; Luo, LC; Wang, XT; Bian, XL; Zhang, F; Wang, KW; Sun, Q in [Li, Yuanheng; Jiao, Wenxuan; Huang, Zongze; Meng, Ying; Luo, Laichun; Wang, KeWei; Sun, Qi] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Sun, Lilan; Zhang, Fang; Wang, KeWei] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao 266021, Peoples R China; [Yang, Taoyi; Tang, Jingshu; Huang, Xiaomin; Wang, Xintong; Bian, Xiling; Wang, KeWei] Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China published Design and Synthesis of Novel Positive Allosteric Modulators of alpha 7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice in 2019, Cited 49. Quality Control of 2-Chloro-6-methylaniline. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8.

A series of novel thiazolo[4,5-d]pyrimidin-7(6H)-ones (3aa-3eq) were designed, synthesized, and evaluated as the type I positive allosteric modulators of human alpha 7 nAChR expressed in Xenopus ooctyes by a two-electrode voltage clamp. The structure-activity relationship analysis identified the compound 3ea as a potent and efficacious PAM with the maximum activation effect of the alpha 7 current of over 1633% in the presence of acetylcholine (100 mu M) and an EC50 = 1.26 mu M. It is highly specific to alpha 7 nAChR over other subtypes of nAChR, 5-HT3A, NMDA, and GABA(A) receptors. Compound 3ea showed an elimination half-life of 10.8 +/- 1.5 h for 3 mg/kg, i.v., and 7.4 +/- 1.1 h for 60 mg/kg, i.g. in rat. It also exhibited sufficient blood-brain barrier penetration with no significant effect on hERG channel. Most importantly, compound 3ea dose-dependently (0.1-1 mg/kg, i.p.) reversed the prepulse inhibition deficit induced by MK-801 in the mouse schizophrenia model. X

Quality Control of 2-Chloro-6-methylaniline. About 2-Chloro-6-methylaniline, If you have any questions, you can contact Li, YH; Sun, LL; Yang, TY; Jiao, WX; Tang, JS; Huang, XM; Huang, ZZ; Meng, Y; Luo, LC; Wang, XT; Bian, XL; Zhang, F; Wang, KW; Sun, Q or concate me.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

COA of Formula: C7H4Cl2O2. In 2019 J MED CHEM published article about PLASMODIUM-BERGHEI; CATALYZED AMINATION; CYTOCHROME-B; LIVER-STAGE; MALARIA; VIVAX; CHALLENGES; RESISTANT; PROPHYLAXIS; MUTATIONS in [Dodean, Rozalia A.; Kancharla, Papireddy; Li, Yuexin; Winter, Rolf W.; Riscoe, Michael K.; Kelly, Jane X.] Portland State Univ, Dept Chem, Portland, OR 97201 USA; [Dodean, Rozalia A.; Li, Yuexin; Smilkstein, Martin J.; Pou, Sovitj; Winter, Rolf W.; Riscoe, Michael K.; Kelly, Jane X.] Dept Vet Affairs Med Ctr, Portland, OR 97239 USA; [Melendez, Victor; Read, Lisa; Bane, Charles E.; Vesely, Brian; Kreishman-Deitrick, Mara; Black, Chad; Li, Qigui; Sciotti, Richard J.; Olmeda, Raul; Thu-Lan Luong; Gaona, Heather; Potter, Brittney; Sousa, Jason; Marcsisin, Sean; Caridha, Diana; Xie, Lisa; Vuong, Chau; Zeng, Qiang; Zhang, Jing; Zhang, Ping; Lin, Hsiuling; Butler, Kirk; Roncal, Norma; Gaynor-Ohnstad, Lacy; Leed, Susan E.; Nolan, Christina] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA; [Huezo, Stephanie J.; Rasmussen, Stephanie A.; Cooper, Roland A.] Dominican Univ Calif, Dept Nat Sci & Math, San Rafael, CA 94901 USA; [Stephens, Melissa T.; Tan, John C.] Univ Notre Dame, Genom Core Facil, Notre Dame, IN 46556 USA; [Tan, John C.] Univ Notre Dame, Eck Inst Global Hlth, Notre Dame, IN 46556 USA in 2019, Cited 53. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual-stage activity against both liver stage and blood-stage malaria. Several lead compounds generated from structural optimization of a large library of novel acridones exhibit efficacy in the following systems: (1) picomolar inhibition of in vitro Plasmodium falciparum blood-stage growth against multidrug-resistant parasites; (2) curative efficacy after oral administration in an erythrocytic Plasmodium yoelii murine malaria model; (3) prevention of in vitro Plasmodium berghei sporozoite-induced development in human hepatocytes; and (4) protection of in vivo P. berghei sporozoite-induced infection in mice. This study offers the first account of liver-stage antimalarial activity in an acridone chemotype. Details of the design, chemistry, structure-activity relationships, safety, metabolic/pharmacokinetic studies, and mechanistic investigation are presented herein.

COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dodean, RA; Kancharla, P; Li, YX; Melendez, V; Read, L; Bane, CE; Vesely, B; Kreishman-Deitrick, M; Black, C; Li, QG; Sciotti, RJ; Olmeda, R; Luong, TL; Gaona, H; Potter, B; Sousa, J; Marcsisin, S; Caridha, D; Xie, LS; Vuong, C; Zeng, Q; Zhang, J; Zhang, P; Lin, HL; Butler, K; Roncal, N; Gaynor-Ohnstad, L; Leed, SE; Nolan, C; Huezo, SJ; Rasmussen, SA; Stephens, MT; Tan, JC; Cooper, RA; Smilkstein, MJ; Pou, S; Winter, RW; Riscoe, MK; Kelly, JX or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. In 2019 J MED CHEM published article about MYOFIBROBLAST DIFFERENTIATION; MURINE MODEL; FIBROSIS; PATHWAY; TISSUE; CYTOSKELETON; CONTRACTION; DERIVATIVES; MECHANISMS; BLEOMYCIN in [Kahl, Dylan J.; Hutchings, Kim M.; Larsen, Scott D.] Univ Michigan, Coll Pharm, Vahlteich Med Chem Core, Ann Arbor, MI 48109 USA; [Wen, Bo; Sun, Duxin] Univ Michigan, Coll Pharm, UM Pharmcokinet Core, Ann Arbor, MI 48109 USA; [Khanna, Dinesh; Tsou, Pei-Suen; Campbell, Phillip L.; Fox, David A.] Univ Michigan, Med Ctr, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA; [Khanna, Dinesh; Tsou, Pei-Suen; Campbell, Phillip L.; Fox, David A.] Univ Michigan, Med Ctr, Clin Autoimmun Ctr Excellence, Ann Arbor, MI 48109 USA; [Lisabeth, Erika Mathes; Haak, Andrew J.; Leipprandt, Jeffrey R.; Dexheimer, Thomas; Neubig, Richard R.] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA; [Bailie, Marc] Michigan State Univ, Vivo Facil, E Lansing, MI 48824 USA in 2019, Cited 47. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Through a phenotypic high-throughput screen using a serum response element luciferase promoter, we identified a novel 5-aryl-1,3,4-oxadiazol-2-ylthiopropionic acid lead inhibitor of Rho/myocardin-related transcription factor (MRTF)/serum response factor (SRF)-mediated gene transcription with good potency (IC50 = 180 nM). We were able to rapidly improve the cellular potency by 5 orders of magnitude guided by sharply defined and synergistic SAR. The remarkable potency and depth of the SAR, as well as the relatively low molecular weight of the series, suggests, but does not prove, that binding to the unknown molecular target may be occurring through a covalent mechanism. The series nevertheless has no observable cytotoxicity up to 100 mu M. Ensuing pharmacokinetic optimization resulted in the development of two potent and orally bioavailable anti-fibrotic agents that were capable of dose-dependently reducing connective tissue growth factor gene expression in vitro as well as significantly reducing the development of bleomycin-induced dermal fibrosis in mice in vivo.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Kahl, DJ; Hutchings, KM; Lisabeth, EM; Haak, AJ; Leipprandt, JR; Dexheimer, T; Khanna, D; Tsou, PS; Campbell, PL; Fox, DA; Wen, B; Sun, DX; Bailie, M; Neubig, RR; Larsen, SD or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Authors Purkait, A; Jana, CK in GEORG THIEME VERLAG KG published article about DONOR-ACCEPTOR CYCLOPROPANES; ASYMMETRIC ALPHA-AMINOXYLATION; DIELS-ALDER; CYCLOADDITION REACTIONS; ANNULATION REACTION; EFFICIENT APPROACH; CARBONYL-COMPOUNDS; ALDOL SYNTHESIS; ENE REACTION; ONE-POT in [Purkait, Anisha; Jana, Chandan K.] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India in 2019, Cited 76. Quality Control of 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Unlike other alkylamines, benzylamines upon reaction with a nitrosoarene undergo oxidation to the corresponding imines. A direct amination of benzylamines, which was difficult to achieve due to its facile oxidation, to the corresponding hydrazones is reported. A wide variety of benzylamines and N-heterocycles were reacted with nitrosoarenes to provide structurally diverse hydrazones and hydrazides, respectively. Moreover, the direct N-amination reaction was applied to the one-pot synthesis of triazoles.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Purkait, A; Jana, CK or concate me.. Quality Control of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design, synthesis and biological evaluation of novel 2,4-bismorpholinothieno[3,2-d ]pyrimidine and 2-morpholinothieno[3,2-d] pyrimidinone derivatives as potent antitumor agents published in 2020. Name: 2-Chloro-6-methylaniline, Reprint Addresses Hou, YL; Zhao, YF (corresponding author), Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wenhua Rd, Shenyang 110016, Peoples R China.. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline

To develop novel therapeutic agents with anticancer activities, two series of novel 2,4-bismorpholinyl-thieno [3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives were designed, synthesized and evaluated for their biological activities. Among them, compound A(12) showed the most potent antitumor activities against HCT116, PC-3, MCF-7, A549 and MDA-MB-231 cell lines with IC50 values of 3.24 mu M, 14.37 mu M, 7.39 mu M, 7.10 mu M, and 16.85 mu M, respectively. Further explorations in bioactivity were conducted to clarify the anticancer mechanism of compound A(12). The results showed that compound A(12) obviously inhibited the proliferation of A549 cell lines and decreased mitochondrial membrane potential, which led to the apoptosis of cancer cells and suppressed the migration of tumor cells.

Name: 2-Chloro-6-methylaniline. About 2-Chloro-6-methylaniline, If you have any questions, you can contact Ye, TY; Han, YF; Wang, RX; Yan, PZ; Chen, SW; Hou, YL; Zhao, YF or concate me.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. Wang, MF; Mi, Y; Hu, FL; Niu, Z; Yin, XH; Huang, Q; Wang, HF; Lang, JP in [Wang, Meng-Fan; Hu, Fei-Long; Niu, Zheng; Wang, Hui-Fang; Lang, Jian-Ping] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China; [Wang, Meng-Fan; Mi, Yan; Hu, Fei-Long; Yin, Xian-Hong; Huang, Qin] Guangxi Univ Nationalities, Guangxi Key Lab Chem & Engn Forest Prod, Nanning 530006, Peoples R China published Coordination-Driven Stereospecific Control Strategy for Pure Cycloisomers in Solid-State Diene Photocycloaddition in 2020, Cited 49. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

To obtain a pure product without the isomer byproducts is a goal that many chemists are pursuing. As one kind of very important synthesis method, the photochemical reaction is simple and straightforward yet low-selective. In this work, a coordination interaction based oriented synthesis strategy has been proposed to realize the precise stereochemical control of the isomeric cyclic compounds in the photocycloaddition reaction. Through fixing the reactants via coordination interactions, the arrangements and configurations of the reactants can be adjusted, thereby successfully producing all of the related photocycloaddition products without isomer byproducts for the first time. This work not only provides a new route to synthesize the pure cyclic compounds but also expands the application of the photocycloaddition reaction.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Wang, MF; Mi, Y; Hu, FL; Niu, Z; Yin, XH; Huang, Q; Wang, HF; Lang, JP or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics