Month: November 2021

I found the field of Agriculture; Chemistry; Food Science & Technology very interesting. Saw the article Rational Optimization and Action Mechanism of Novel Imidazole (or Imidazolium)-Labeled 1,3,4-Oxadiazole Thioethers as Promising Antibacterial Agents against Plant Bacterial Diseases published in 2019. Recommanded Product: 2,4-Dichlorobenzoic acid, Reprint Addresses Song, BA; Yang, S (corresponding author), Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr R&D Fine Chem, Guiyang 550025, Guizhou, Peoples R China.; Yang, S (corresponding author), East China Univ Sci & Technol, Coll Pharm, Shanghai 200237, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

The emergence and widespread occurrence of plant bacterial diseases that cause global production constraints have become major challenges to agriculture worldwide. To promote the discovery and development of new bactericides, imidazole-labeled 1,3,4-oxadiazole thioethers were first fabricated by integrating the crucially bioactive scaffolds of the imidazole motif and 1,3,4-oxadiazole skeleton in a single molecular architecture. Subsequently, a superior antibacterial compound A(6) was gradually discovered possessing excellent competence against plant pathogens Xanthomonas oryzae pv oryzae and Xanthomonas axonopodis pv citri with EC50 values of 0.734 and 1.79 mu g/mL, respectively. These values were better than those of commercial agents bismerthiazol (92.6 mu g/mL) and thiodiazole copper (77.0 mu g/mL). Further modifying the imidazole moiety into the imidazolium scaffold led to the discovery of an array of potent antibacterial compounds providing the corresponding minimum EC50 values of 0.295 and 0.607 mu g/mL against the two strains. Moreover, a plausible action mechanism for attacking pathogens was proposed based on the concentration dependence of scanning electron microscopy, transmission electron microscopy, and fluorescence microscopy images. Given the simple molecular structures, easy synthetic procedure, and highly efficient bioactivity, imidazole (or imidazolium)-labeled 1,3,4-oxadiazole thioethers can be further explored and developed as promising indicators for the development of commercial drugs.

Recommanded Product: 2,4-Dichlorobenzoic acid. Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 95-49-8. Authors Bagherzadeh, N; Sardarian, AR; Eslahi, H in ELSEVIER published article about in [Bagherzadeh, Nastaran; Sardarian, Ali Reza; Eslahi, Hassan] Shiraz Univ, Coll Sci, Chem Dept, Shiraz 7194684759, Iran in 2021.0, Cited 118.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

A magnetic nanocatalyst was purveyed as a heterogeneous recoverable palladium-based catalyst anchored on green, sustainable and phosphine free support. Resulted Fe3O4@SiO2-Phen-Pd(0) nanocatalyst bearing powerful phenanthroline ligand was thoroughly characterized by physicochemical approaches like UV-vis, FT-IR, EDX, XRD, TGA, ICP, VSM, DLS, FESEM, and TEM analyses. After finding trustable data, the obtained magnetic catalyst was considered to be applied in the Suzuki-Miyaura type C-C couplings and getting corresponding tetrazoles using arylboronic acid derivatives as alternate precursors of aromatic halides and stupendous data were observed.

Recommanded Product: 95-49-8. Welcome to talk about 95-49-8, If you have any questions, you can contact Bagherzadeh, N; Sardarian, AR; Eslahi, H or send Email.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Authors Yavir, K; Konieczna, K; Marcinkowski, L; Kloskowski, A in ELSEVIER published article about GAS-CHROMATOGRAPHY; ANALYTICAL-CHEMISTRY; POLYMER; WATER in [Yavir, Kateryna; Konieczna, Karolina; Marcinkowski, Lukasz; Kloskowski, Adam] Gdansk Univ Technol, Fac Chem, Dept Phys Chem, Narutowicza Str 11-12, PL-80233 Gdansk, Poland in 2020.0, Cited 51.0. Name: 1-Chloro-2-methylbenzene. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

A silica-based network was used to immobilize ionic liquid-based ionogels and applied as a fiber coating for solid-phase microextraction (SPME). The ionogels were prepared by a sol-gel process, using two ionic liquids, triethylsulfonium bis(trifluoromethylsulfonyl)imide ([Set(3)][TFSI]) and 1-butyl-1-methylpiperidinium bis(trifluoromethylsulfonyl)imide ([C(4)C(1)Pip] [TFSI]), as well as their equimolar mixture. Methyltrimethoxysilane was used as the sol-gel precursor, and trifluoroacetic acid as a reaction catalyst. The fabricated ionogel fibers were evaluated as sorbent coating in headspace SPME combined with gas chromatography with barrier ionization discharge detection for volatile organic compounds (VOCs). The fibers showed a high affinity to aromatic VOCs, yielding good sensitivity and precision. Then, the developed method was applied to the analysis of aqueous samples. During the study, the main extraction parameters, i.e., salt concentration, extraction time, and temperature, were optimized for maximum fiber sorption and to maximize the enrichment factors. The average limits of detection were found to be 0.15 mu g L-1, 0.40 mu g L-1, and 0.07 mu g L-1, and the enrichment factors were in the 25700-61000, 33200-84700, and 29100-96500 ranges for [Set(3)], [C4C1 Pip] and [Set(3)/C4C1 Pip], respectively. The single fiber and fiber-to-fiber reproducibilities were below 11.2% and 30.6%, respectively. The results of this work suggest the possibility of fabricating selected extractants based on the physicochemical properties of the ionic liquids and target analytes.

Bye, fridends, I hope you can learn more about C7H7Cl, If you have any questions, you can browse other blog as well. See you lster.. Name: 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Bis-salophen palladium complex immobilized on Fe3O4@SiO2 nanoparticles as a highly active and durable phosphine-free catalyst for Heck and copper-free Sonogashira coupling reactions WOS:000460780300033 published article about SCHIFF-BASE COMPLEX; SUZUKI-MIYAURA; MAGNETIC NANOPARTICLES; SUPPORTED-PALLADIUM; HETEROGENEOUS CATALYST; FE3O4 NANOPARTICLES; EFFICIENT CATALYST; MIZOROKI-HECK; 5-SUBSTITUTED 1H-TETRAZOLES; RECOVERABLE CATALYSTS in [Sardarian, Ali Reza; Kazemnejadi, Milad; Esmaeilpour, Mohsen] Shiraz Univ, Dept Chem, Coll Sci, Shiraz 7194684795, Iran in 2019.0, Cited 72.0. HPLC of Formula: C7H7Cl. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

New Fe3O4@SiO2 core-shell superparamagnetic nanoparticles functionalized by a bis-salophen Schiff base Pd complex were synthesized and employed as an efficient magnetic nanocatalyst in the Heck and Sonogashira cross coupling reactions. The synthesized nanostructures were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), dynamic light scattering (DLS), energy dispersive X-ray analysis (EDX), X-ray photoelectron spectroscopy (XPS), elemental analysis (CHN), cyclic voltammetry (CV), Brunauer-Emmett-Teller analysis (BET), and UV-vis spectroscopy. The morphology and size of the nanoparticles were investigated by FE-SEM and TEM analyses. Furthermore, the magnetic properties of the catalyst were investigated by VSM analysis. The loading content and leaching amounts of palladium on the catalyst were measured by inductively coupled plasma (ICP) analysis. Also, the thermal behavior of this magnetic heterogeneous catalyst was studied using a TGA instrument. This heterogeneous catalytic system showed a good performance in the coupling of aryl halides with alkynes (Sonogashira reaction) as well as aryl halides with alkene derivatives (Heck reaction). High to excellent yields were achieved for these C-C coupling reactions. The catalyst can be simply separated from the reaction media by an external magnet and reused for eight consecutive runs without any significant loss of activity. Finally, the kinetics of the reactions were studied in this work.

Bye, fridends, I hope you can learn more about C7H7Cl, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C7H7Cl

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Design and Synthesis of Novel Positive Allosteric Modulators of alpha 7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice WOS:000455561400010 published article about VITRO PHARMACOLOGICAL CHARACTERIZATION; RELEASE; AGONIST; SCHIZOPHRENIA; DISCOVERY; TARGETS; SERIES; ACID in [Li, Yuanheng; Jiao, Wenxuan; Huang, Zongze; Meng, Ying; Luo, Laichun; Wang, KeWei; Sun, Qi] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Sun, Lilan; Zhang, Fang; Wang, KeWei] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao 266021, Peoples R China; [Yang, Taoyi; Tang, Jingshu; Huang, Xiaomin; Wang, Xintong; Bian, Xiling; Wang, KeWei] Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China in 2019, Cited 49. Recommanded Product: 87-63-8. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

A series of novel thiazolo[4,5-d]pyrimidin-7(6H)-ones (3aa-3eq) were designed, synthesized, and evaluated as the type I positive allosteric modulators of human alpha 7 nAChR expressed in Xenopus ooctyes by a two-electrode voltage clamp. The structure-activity relationship analysis identified the compound 3ea as a potent and efficacious PAM with the maximum activation effect of the alpha 7 current of over 1633% in the presence of acetylcholine (100 mu M) and an EC50 = 1.26 mu M. It is highly specific to alpha 7 nAChR over other subtypes of nAChR, 5-HT3A, NMDA, and GABA(A) receptors. Compound 3ea showed an elimination half-life of 10.8 +/- 1.5 h for 3 mg/kg, i.v., and 7.4 +/- 1.1 h for 60 mg/kg, i.g. in rat. It also exhibited sufficient blood-brain barrier penetration with no significant effect on hERG channel. Most importantly, compound 3ea dose-dependently (0.1-1 mg/kg, i.p.) reversed the prepulse inhibition deficit induced by MK-801 in the mouse schizophrenia model. X

Welcome to talk about 87-63-8, If you have any questions, you can contact Li, YH; Sun, LL; Yang, TY; Jiao, WX; Tang, JS; Huang, XM; Huang, ZZ; Meng, Y; Luo, LC; Wang, XT; Bian, XL; Zhang, F; Wang, KW; Sun, Q or send Email.. Recommanded Product: 87-63-8

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: C7H7Cl. In 2019.0 ORGANOMETALLICS published article about N-ARYLATION; (HETERO)ARYL CHLORIDES; HALIDES; LIGANDS; AMIDES; LACTAMS in [Chang, Raymond K.; Clairmont, Brice P.; Lin, Shirley; MacArthur, Amy H. Roy] US Naval Acad, Dept Chem, 572 Holloway Rd, Annapolis, MD 21402 USA in 2019.0, Cited 34.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8.

A concurrent tandem catalytic (CTC) methodology has been developed for the amidation of aryl chlorides where the aryl chloride is first converted to an aryl iodide via halogen exchange and the aryl iodide is subsequently transformed into the aryl amide. A variety of aryl chlorides were converted to aryl amides in up to 85% isolated yield using 20 mol % CuI, 60 mol % N,N’-cyclohexane-1,2-diamine, 2.2 equiv of K2CO3, and 1.05-1.5 equiv of amide in acetonitrile at 200 degrees C after 0.75-1 h. The same copper/ligand system served as multifunctional catalyst for both steps of the concurrent catalytic process with iodide present in substoichiometric amounts. Mechanistic studies were consistent with CTC amidation occurring via a nonradical mechanism. Kinetic modeling was conducted to investigate the effect of competitive direct amidation of an aryl chloride or aryl bromide on the formation of product over time during a CTC amidation reaction.

Welcome to talk about 95-49-8, If you have any questions, you can contact Chang, RK; Clairmont, BP; Lin, S; MacArthur, AHR or send Email.. HPLC of Formula: C7H7Cl

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Highly Efficient Synthesis of Hindered 3-Azoindoles via Metal-Free C-H Functionalization of Indoles WOS:000513827300011 published article about ARYLATION; PHOTOSWITCHES; DYNAMICS; DYES in [Jacob, Nicolas; Guillemard, Lucas; Wencel-Delord, Joanna] Univ Haute Alsace, Lab Innovat Mol & Applicat, ECPM, CNRS,UMR 7042,Univ Strasbourg, 25 Rue Becquerel, F-67087 Strasbourg, France in 2020, Cited 45. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8. SDS of cas: 87-63-8

Although 3-azoindoles have recently emerged as an appealing family of photoswitch molecules, the synthesis of such compounds has been poorly covered in the literature. Herein a high-yielding and operationally simple protocol is reported allowing the synthesis of 3-azoindoles, featuring important steric hindrance around the azo motif. Remarkably, this C-H coupling is characterized by excellent atom economy and occurs under metal-free conditions, at room temperature, and within few minutes, delivering the expected products in excellent yields (quantitatively in most of the cases). Accordingly, a library of new molecules, with potential applications as photochromic compounds, is prepared.

SDS of cas: 87-63-8. Welcome to talk about 87-63-8, If you have any questions, you can contact Jacob, N; Guillemard, L; Wencel-Delord, J or send Email.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Authors Liao, RQ; Li, WT; Kang, ZJ; Tang, L; Yang, B; Wang, L in SPRINGER published article about POLYCHLORINATED-BIPHENYLS PCBS; POLYBROMINATED DIPHENYL ETHERS; AROMATIC-HYDROCARBONS PAHS; DIBENZO-P-DIOXINS; SPATIAL-DISTRIBUTION; MARINE FISH; ESTUARY; TRENDS; PBDES; WATER in [Liao, Riquan; Kang, Zhenjun; Yang, Bin] Beibu Gulf Univ, Guangxi Key Lab Beibu Gulf Marine Biodivers Conse, Qinzhou 535000, Guangxi, Peoples R China; [Li, Weitao; Wang, Liang] Shanghai Univ, Inst Nanochem & Nanobiol, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China; [Tang, Liang] Shanghai Univ, Shanghai Inst Appl Radiat, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China in 2019.0, Cited 28.0. Computed Properties of C7H7Cl. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

To enhance our understanding on environmental conditions of the Maowei Sea in Guangxi province, China, the concentration and distribution of 22 chlorobenzene compounds (CBs) in the surface sediment were determined by gas chromatography-mass spectrometry (GC-MS). The relationship of the sediment between CBs and total organic carbon (TOC) was also investigated. The results showed that a total of eight kinds of CBs compounds were detected in the sediment samples which were collected from the coastal environment of the Maowei Sea, with an average concentration of 15.3ngg(-1) (the concentration range, 2.5-61.5ngg(-1)). The rank of their average concentrations was as follows: 2,3,4,5,6-pentachlorotoluene>hexachlorobenzene, 2-chlorotoluene, 3-chlorotoluene and 2,3-dichlorotoluene>2,4-dichlorotoluene>4-chlorotoluene>pentachlorobenzene. Most CBs were distributed in sediments along the east coast of the Maowei Sea. For total TOC content in sediments, the concentration in the sampling locations was similar, with a mean concentration of 8.83gkg(-1) (the concentration range, 4.87-20.13gkg(-1)). However, there was no significant correlation between the concentration of TOC and total CBs. Compared to the corresponding CBs in the sediment of other coastal areas in mainland China and other countries, the value of CBs in the Maowei Sea was low.

Computed Properties of C7H7Cl. Bye, fridends, I hope you can learn more about C7H7Cl, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019.0 ANGEW CHEM INT EDIT published article about CROSS-COUPLING REACTIONS; N-HETEROCYCLIC CARBENES; OXIDATIVE ADDITION; C-N; ELECTRONIC-PROPERTIES; HALIDE-COMPLEXES; ALPHA-ARYLATION; NHC COMPLEXES; LIGANDS; CHEMISTRY in [Scherpf, Thorsten; Rodstein, Ilja; Schar, Lennart T.; Gessner, Viktoria H.] Ruhr Univ Bochum, Fac Chem & Biochem, Chair Inorgan Chem 2, Univ Str 150, D-44801 Bochum, Germany; [Weber, Philip; Lichte, Dominik; Goossen, Lukas J.] Ruhr Univ Bochum, Evonik Chair Organ Chem, ZEMOS, Univ Str 150, D-44801 Bochum, Germany in 2019.0, Cited 85.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. Computed Properties of C7H7Cl

Ylide-functionalized phosphine ligands (YPhos) were rationally designed to fit the requirements of Buchwald-Hartwig aminations at room temperature. This ligand class combines a strong electron-donating ability comparable to NHC ligands with high steric demand similar to biaryl phosphines. The active Pd species are stabilized by agostic C-H center dot center dot center dot Pd rather than by Pd-arene interactions. The practical advantage of YPhos ligands arises from their easy and scalable synthesis from widely available, inexpensive starting materials. Benchmark studies showed that YPhos-Pd complexes are superior to the best-known phosphine ligands in room-temperature aminations of aryl chlorides. The utility of the catalysts was demonstrated by the synthesis of various arylamines in high yields within short reaction times.

Welcome to talk about 95-49-8, If you have any questions, you can contact Weber, P; Scherpf, T; Rodstein, I; Lichte, D; Schar, LT; Goossen, LJ; Gessner, VH or send Email.. Computed Properties of C7H7Cl

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 2-Chloro-6-methylaniline. Ye, TY; Han, YF; Wang, RX; Yan, PZ; Chen, SW; Hou, YL; Zhao, YF in [Ye, Tianyu; Han, Yufei; Wang, Ruxin; Yan, Pingzhen; Chen, Shaowei; Hou, Yunlei; Zhao, Yanfang] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wenhua Rd, Shenyang 110016, Peoples R China published Design, synthesis and biological evaluation of novel 2,4-bismorpholinothieno[3,2-d ]pyrimidine and 2-morpholinothieno[3,2-d] pyrimidinone derivatives as potent antitumor agents in 2020, Cited 30. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8.

To develop novel therapeutic agents with anticancer activities, two series of novel 2,4-bismorpholinyl-thieno [3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives were designed, synthesized and evaluated for their biological activities. Among them, compound A(12) showed the most potent antitumor activities against HCT116, PC-3, MCF-7, A549 and MDA-MB-231 cell lines with IC50 values of 3.24 mu M, 14.37 mu M, 7.39 mu M, 7.10 mu M, and 16.85 mu M, respectively. Further explorations in bioactivity were conducted to clarify the anticancer mechanism of compound A(12). The results showed that compound A(12) obviously inhibited the proliferation of A549 cell lines and decreased mitochondrial membrane potential, which led to the apoptosis of cancer cells and suppressed the migration of tumor cells.

Application In Synthesis of 2-Chloro-6-methylaniline. About 2-Chloro-6-methylaniline, If you have any questions, you can contact Ye, TY; Han, YF; Wang, RX; Yan, PZ; Chen, SW; Hou, YL; Zhao, YF or concate me.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics