Month: November 2021

Name: 2,6-Dichlorobenzoic acid. Authors Pacheco-Benichou, A; Ivendengani, E; Kostakis, IK; Besson, T; Fruit, C in MDPI published article about in [Pacheco-Benichou, Alexandra; Ivendengani, Eugenie; Besson, Thierry; Fruit, Corinne] Normandie Univ, UNIROUEN, INSA Rouen, CNRS,COBRA UMR 6014, F-76000 Rouen, France; [Kostakis, Ioannis K.] Natl & Kapodistrian Univ Athens, Dept Pharm, Div Pharmaceut Chem, Athens 15771, Greece in 2021.0, Cited 54.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6

Copper-catalyzed Csp2-Csp2 bond forming reactions through C-H activation are still one of the most useful strategies for the diversification of heterocyclic moieties using various coupling partners. A catalytic protocol for the C-H (hetero)arylation of thiazolo[5,4-f]quinazolin-9(8H)-ones and more generally fused-pyrimidinones using catalyst loading of CuI with diaryliodonium triflates as aryl source under microwave irradiation has been disclosed. The selectivity of the transfer of the aryl group was also disclosed in the case of unsymmetrical diaryliodonium salts. Specific phenylation of valuable fused-pyrimidinones including quinazolinone are provided. This strategy enables a rapid access to an array of various (hetero)arylated N-containing polyheteroaromatics as new potential bioactive compounds.

Name: 2,6-Dichlorobenzoic acid. Welcome to talk about 50-30-6, If you have any questions, you can contact Pacheco-Benichou, A; Ivendengani, E; Kostakis, IK; Besson, T; Fruit, C or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Dai, QZ; Chen, JW; Gao, CM; Sun, QS; Yuan, ZG; Jiang, YY in [Dai, Qiuzi] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; [Dai, Qiuzi; Chen, Jiwei; Gao, Chunmei; Sun, Qinsheng; Yuan, Zigao; Jiang, Yuyang] Tsinghua Univ, Grad Sch Shenzhen, State Key Lab Chem Oncogen, Key Lab Chem Biol, Shenzhen 518055, Peoples R China; [Gao, Chunmei] Shenzhen Univ, Coll Chem & Chem Engn, Shenzhen 518060, Peoples R China; [Jiang, Yuyang] Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China published Design, synthesis and biological evaluation of novel phthalazinone acridine derivatives as dual PARP and Topo inhibitors for potential anticancer agents in 2020, Cited 37. Computed Properties of C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

In this study, we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibitors. MTF assays indicated that most of the compounds significantly inhibited multiple cancer cells proliferation. In addition, all the compounds displayed Topo II inhibition activity at 10 mol/L, and also possessed good PARP-1 inhibitory activities. Subsequent mechanistic studies showed that compound 9a induced remarkable apoptosis and caused prominent S cell cycle arrest in HCT116 cells. Our study suggested that 9a inhibiting Topo and PARP concurrently can be a potential lead compound for cancer therapy. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Name: 1-Chloro-2-methylbenzene. Authors Gupta, SSR; Vinu, A; Kantam, ML in WILEY-V C H VERLAG GMBH published article about in [Gupta, Shyam Sunder R.; Kantam, Mannepalli Lakshmi] Inst Chem Technol, Dept Chem Engn, Mumbai 400019, Maharashtra, India; [Vinu, Ajayan] Univ Newcastle, Fac Engn & Built Environm, Sch Engn, Global Innovat Ctr Adv Nanomat GICAN, Callaghan, NSW 2308, Australia in 2021.0, Cited 62.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

One-pot synthesis of furan-2,5-dimethylcarboxylate (FDMC) from 5-hydroxymethylfurfural (HMF) is highly demanding for the commercial production of polyethylene furanoate (PEF). Herein, a direct synthesis of FDMC is reported from oxidative esterification of HMF using ultrafine CuO particles dispersed on nitrogen-doped hollow carbon nanospheres (CuO/N-C-HNSs) as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidizing and methylating reagent. The CuO/N-C-HNSs was prepared through a template protection-sacrifice strategy using SiO2 as a sacrificial template and histidine as the precursor for N and C. N-doping facilitated a strong interaction between the support and copper species, affording formation of CuO nanoparticles of less than 10 nm in size. By virtue of the highly dispersed CuO nanoparticles and a high BET surface area 373 m(2)/g, the CuO/N-C-HNSsshows excellent catalytic performance in the selective conversion of HMF into FDMC affording 93 % yield of the desired product with a TON value of 49. Furthermore, the oxidative esterification involving (SPC)-C-3-H bond functionalization is also demonstrated using the same catalyst.

Bye, fridends, I hope you can learn more about C7H7Cl, If you have any questions, you can browse other blog as well. See you lster.. Name: 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 50-84-0. Wang, MW; Zhu, HH; Wang, PY; Zeng, D; Wu, YY; Liu, LW; Wu, ZB; Li, Z; Yang, S in [Wang, Ming-Wei; Zhu, Huai-He; Wang, Pei-Yi; Zeng, Dan; Wu, Yuan-Yuan; Liu, Li-Wei; Wu, Zhi-Bing; Yang, Song] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Ctr R&D Fine Chem,Minist Educ, Guiyang 550025, Guizhou, Peoples R China; [Li, Zhong; Yang, Song] East China Univ Sci & Technol, Coll Pharm, Shanghai 200237, Peoples R China published Synthesis of Thiazolium-Labeled 1,3,4-Oxadiazole Thioethers as Prospective Antimicrobials: In Vitro and in Vivo Bioactivity and Mechanism of Action in 2019, Cited 58. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

In this study, a type of thiazolium-labeled 1,3,4-oxadiazole thioether bridged by diverse alkyl chain lengths was constructed. The antimicrobial activity of the fabricated thioether toward plant pathogenic bacteria and fungi was then screened. Antibacterial evaluation indicated that title compounds possess specific characteristics that enable them to severely attack three phytopathogens, namely, Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri with minimal EC50 values of 0.10, 3.27, and 3.50 mu g/mL, respectively. Three-dimensional quantitative structure-activity relationship models were established to direct the following excogitation for exploring higher active drugs. The in vivo study against plant bacterial diseases further identified the prospective application of title compounds as alternative antibacterial agents. The proteomic technique, scanning electron microscopy patterns, and fluorescence spectrometry were exploited to investigate the antibacterial mechanism. Additionally, some target compounds performed superior inhibitory actions against three tested fungal strains. In view of their simple molecular architecture and highly efficient bioactivity, these substrates could be further explored as promising surrogates for fighting against plant microbial infections.

Welcome to talk about 50-84-0, If you have any questions, you can contact Wang, MW; Zhu, HH; Wang, PY; Zeng, D; Wu, YY; Liu, LW; Wu, ZB; Li, Z; Yang, S or send Email.. SDS of cas: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Acylation of 25-hydroxyprotopanaxatriol with aromatic acids increases cytotoxicity WOS:000484878400054 published article about PANAX-GINSENG; IN-VITRO; ANTITUMOR EVALUATION; ANTICANCER ACTIVITY; PROSTATE-CANCER; GINSENOSIDES; DERIVATIVES; PROLIFERATION; SEMISYNTHESIS; APOPTOSIS in [Lv, Liyan; Piao, Huri] Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Coll Pharm, Yanji 133002, Peoples R China; [Lv, Liyan; Lu, Jincai] Shenyang Pharmaceut Univ, Dept Med Plant, Shenyang 110016, Liaoning, Peoples R China; [Zhang, Hongyu; Wang, Xude; Su, Guangyue; Zhao, Yuqing] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang, Liaoning, Peoples R China; [Zhao, Yuqing] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China in 2019, Cited 36. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Application In Synthesis of 2,4-Dichlorobenzoic acid

20(R)-25-hydroxyprotopanaxadiol (25-OH-PPD) is a natural compound showing a variety of anti-tumor effects. In an attempt to search for a new anti-cancer compound with higher antitumor activities, we designed and synthesized a series of 25-OH-PPD derivatives. Cytotoxicity assay of these derivatives towards MCF-7, A549, U87, HO-8901, Hela cancer cell lines and normal IOSE144 cell lines were tested by MTF assay. Results showed that compared with compound 25-OH-PPD, Compounds 4, 5, 6, 10, 11 showed strong anticancer activity, and all compounds showed low toxicity or no toxicity for normal cells. In particular, compound 6 exhibited the best anti-tumor activity in all cancer cell lines (MCF-7, A549, U87, HO-8901, and Hela) with IC50 values of 5.04 mu M, 1.36 mu M, 3.24 mu M, 3.47 mu M, 4.57 mu M, respectively. Among the five cell lines, all the compounds showed strong inhibition on A549 cells. Further studies showed that Compound 6 significantly inhibited the proliferation of A549 cells by inducing apoptosis. Our results indicate that Compound 6 is a potential anticancer inhibitor and provides a theoretical basis for further research.

Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Product Details of 50-30-6. Authors Pacheco-Benichou, A; Ivendengani, E; Kostakis, IK; Besson, T; Fruit, C in MDPI published article about in [Pacheco-Benichou, Alexandra; Ivendengani, Eugenie; Besson, Thierry; Fruit, Corinne] Normandie Univ, UNIROUEN, INSA Rouen, CNRS,COBRA UMR 6014, F-76000 Rouen, France; [Kostakis, Ioannis K.] Natl & Kapodistrian Univ Athens, Dept Pharm, Div Pharmaceut Chem, Athens 15771, Greece in 2021.0, Cited 54.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6

Copper-catalyzed Csp2-Csp2 bond forming reactions through C-H activation are still one of the most useful strategies for the diversification of heterocyclic moieties using various coupling partners. A catalytic protocol for the C-H (hetero)arylation of thiazolo[5,4-f]quinazolin-9(8H)-ones and more generally fused-pyrimidinones using catalyst loading of CuI with diaryliodonium triflates as aryl source under microwave irradiation has been disclosed. The selectivity of the transfer of the aryl group was also disclosed in the case of unsymmetrical diaryliodonium salts. Specific phenylation of valuable fused-pyrimidinones including quinazolinone are provided. This strategy enables a rapid access to an array of various (hetero)arylated N-containing polyheteroaromatics as new potential bioactive compounds.

Welcome to talk about 50-30-6, If you have any questions, you can contact Pacheco-Benichou, A; Ivendengani, E; Kostakis, IK; Besson, T; Fruit, C or send Email.. Product Details of 50-30-6

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2019 BIOORG MED CHEM LETT published article about ACETYLCHOLINE-RECEPTOR AGONIST; PHARMACOLOGICAL CHARACTERIZATION; IDENTIFICATION; APOPTOSIS; SUBUNIT; RELEASE in [Li, Xin; Xie, Wenjun; Huang, Zongze; Sun, Qi] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Xie, Wenjun; Wang, Xintong; Bian, Xiling; Wang, KeWei] Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China; [Wang, KeWei] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao 266021, Shandong, Peoples R China in 2019, Cited 38. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8. SDS of cas: 87-63-8

Structural modifications of nicotinamide, a form of vitamin B3, gave rise to a series of compounds (8aa-8ce) that exhibit activities as type I positive allosteric modulators (PAMs) of human alpha 7 nAChR expressed in Xenopus oocytes in two-electrode voltage clamp assay. The compound 8ai was a potent and efficacious PAM with an EC50 = 3.34 +/- 1.13 mu M and the maximum activation effect of alpha 7 current over 1474 +/- 246% in the presence of acetylcholine (100 mu M). It is highly specific to alpha 7 nAChR over other subtypes of nAChR and 5-HT3A receptors. The structure-activity relationship analysis identified a key skeleton of nicotinamide nucleus critical for biological activity. Taken together, the 8ai as a type I PAM of alpha 7 nAChR may be beneficial for improvement of cognitive deficit.

Welcome to talk about 87-63-8, If you have any questions, you can contact Li, X; Xie, WJ; Wang, XT; Huang, ZZ; Bian, XL; Wang, KW; Sun, Q or send Email.. SDS of cas: 87-63-8

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C7H8ClN. Authors Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL in AMER CHEMICAL SOC published article about in [Dinh, Andrew N.; Maddox, Sean M.; Vaidya, Sagar D.; Saputra, Mirza A.; Nalbandian, Christopher J.; Gustafson, Jeffrey L.] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA in 2020, Cited 54. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Welcome to talk about 87-63-8, If you have any questions, you can contact Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL or send Email.. Formula: C7H8ClN

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: 1-Chloro-2-methylbenzene. In 2020.0 RENEW ENERG published article about COAL-GASIFICATION; PYROLYSIS; BIOMASS; TAR; CATALYST; DISSOCIATION; COMPONENTS; CONVERSION; MECHANISM; CARBON in [Yang, Fu; Hu, Hongyun; Gao, Qiang; Yang, Yuhan; Tang, Hua; Xie, Kang; Liu, Huan; Yao, Hong] Huazhong Univ Sci & Technol, Sch Energy & Power Engn, State Key Lab Coal Combust, Wuhan 430074, Peoples R China; [Liu, Huan] Huazhong Univ Sci & Technol, Sch Energy & Power Engn, Dept New Energy Sci & Engn, Wuhan 430074, Peoples R China; [He, Yao] Guangdong Univ Technol, Sch Environm Sci & Engn, Inst Environm Hlth & Pollut Control, Guangzhou Key Lab Environm Catalysis & Pollut Con, Guangzhou 510006, Peoples R China in 2020.0, Cited 32.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8.

The upgrading of tar is a key issue for the sufficient application of biowaste pyrolysis technology. Molten salt, with high migration and diffusion of ions to prevent the deactivation of coke deposition of tar reforming functional metals, is considered as a feasible catalytic reaction medium and heat carrier for the upgrading of tar. The present study investigated the interactions between small molecular pyrolysis gases (including H-2, CO, CH4) and main tar model compound in ternary carbonate eutectics (Li2CO3-Na2CO3-K2CO3). The results demonstrated that H-2 could be decomposed to produce H radicals, promoting the conversion of toluene into gaseous products. CO32- could consume H radicals required by toluene cracking, making the process toluene polymerized to polycyclic aromatic hydrocarbons be strengthened. On the other hand, CO would react with OH radicals to produce H radicals and could enhance gas-generating process. In addition, toluene could react with CO to form benzaldehyde and phenylacetaldehyde. With the addition of CH4, more H radicals were supposed to be consumed, and toluene cracking process was further inhibited. Finally, the effect sequence of small molecular gases (H-2 > CH4 > CO) on toluene reforming reaction was authenticated by investigating the impacts of introducing any two gases in toluene reforming. (C) 2020 Elsevier Ltd. All rights reserved.

Name: 1-Chloro-2-methylbenzene. Bye, fridends, I hope you can learn more about C7H7Cl, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 87-63-8. Authors Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL in AMER CHEMICAL SOC published article about in [Dinh, Andrew N.; Maddox, Sean M.; Vaidya, Sagar D.; Saputra, Mirza A.; Nalbandian, Christopher J.; Gustafson, Jeffrey L.] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA in 2020, Cited 54. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Welcome to talk about 87-63-8, If you have any questions, you can contact Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL or send Email.. Recommanded Product: 87-63-8

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics