Month: November 2021

Recently I am researching about ENVIRONMENTAL-SAMPLES; DENSITY POLYETHYLENE; HUMAN HEALTH; TOXICITY; PIGMENTS; BEHAVIOR; IDENTIFICATION; COMPOSITES; ORGANISMS; PYROLYSIS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21806140, 51908499]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M662105]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY20B070010, 2017129004429]; Zhejiang University of Technology, China. Published in ELSEVIER in AMSTERDAM ,Authors: Luo, HW; Zhao, YY; Li, Y; Xiang, YH; He, DQ; Pan, XL. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene. SDS of cas: 95-49-8

Most microplastics (MPs) have undergone extensive aging in the environment. Aged MPs exhibit different physical and chemical properties from unaged ones. Here, we studied the effects of accelerated aging on the characteristics and pyrolysis of commercial pigmented MPs, as well as pigments leaching and their interactions in simulated gastric and intestinal fluids of mammals. We report that the carbonyl index, surface area, and color change of MPs increased after aging treatment. Cracks and fragmentation of MPs facilitated the accessibility of light and oxygen to internal layer and therefore accelerated the aging process. TGA/GC-MS analysis showed that the high temperature resistance of MN decreased after aging. Thermal decomposition of pigments and polyethylene occurred in temperature ranges of 340-406 degrees C and 406-550 degrees C, respectively. Mono (di)-alkenes and saturated alkanes were the thermal decomposition products of polyethylene. Aging of MPs also caused an increased release of pigments and prolonged aging time led to more release in simulated fluids. Pigments would result in fluorescence quenching of the enzymes through binding interactions once they were released from MPs into simulated fluids. Charge neutralization and polymer bridging accounted for the formation of pigment-enzyme complexes and flocs. These novel findings will allow us to better assess how aging process affects the characteristics, leaching, and toxicity of MPs. (C) 2020 Published by Elsevier B.V.

SDS of cas: 95-49-8. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Luo, HW; Zhao, YY; Li, Y; Xiang, YH; He, DQ; Pan, XL or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2020.0 J CONTAM HYDROL published article about VOLATILE ORGANIC-COMPOUNDS; PEARL RIVER DELTA; RISK-ASSESSMENT; DRINKING-WATER; HUMAN-HEALTH; DEGRADATION; BENZENE; AQUIFER; REGION; URBAN in [Zhao, Bei; Huang, Fuyang; Zhang, Chong; Xue, Qiang; Liu, Fei] China Univ Geosci Beijing, MOE Key Lab Groundwater Circulat & Environm Evolu, Beijing 100083, Peoples R China; [Zhao, Bei; Huang, Fuyang; Zhang, Chong; Xue, Qiang; Liu, Fei] China Univ Geosci Beijing, Beijing Key Lab Water Resources & Environm Engn, Beijing 100083, Peoples R China; [Huang, Guoxin] Chinese Acad Environm Planning, Beijing 100012, Peoples R China in 2020.0, Cited 64.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. Application In Synthesis of 1-Chloro-2-methylbenzene

Much of the worlds groundwater supply has been contaminated by aromatic hydrocarbons originating from anthropogenic sources. To study the occurrence and distribution characteristics of aromatic hydrocarbons in groundwater, 24 aromatic hydrocarbon compounds were selected: Five BTEX compounds (benzene, toluene, ethylbenzene, o-xylene, m-xylene, and p-xylene), 10 alkyl-substituted benzene, and 9 halogenated aromatics. These aromatic hydrocarbons were then analyzed from 355 samples collected from across China. Results indicated that aromatic hydrocarbons were detected in 59 out of 355 samples. Of the selected aromatic hydrocarbons, BTEX compounds were detected with high frequency and at low concentrations; comparatively, halogenated aromatics were detected with low frequency and at high concentrations. The aromatic hydrocarbon characteristics found in both karst and pore groundwater samples were then determined using their respective hydrogeological conditions and corresponding human activities. In karst groundwater, BTEX compounds were the most frequently detected aromatic hydrocarbon. The high detection frequencies of aromatic hydrocarbons were caused by their rapid migration, owing to the developed conduit system in the sampled karst area. The low concentrations of aromatic hydrocarbons in karst groundwater samples were caused by low-intensity human activity along with special hydrogeological conditions with higher redox potential and the unique compositions of aromatic hydrocarbons. Alkyl-substituted aromatics and halogenated aromatics were detected at higher concentrations in pore groundwater, owing to high-intensity human activity. Aromatic hydrocarbon pollution was gradually decreased along piedmont-alluvial plain-coast line, owing to a decrease in aquifer vulnerability. These were positively correlated with the size of the aquifer’s particles. Samples with a high accumulative concentration of these aromatic hydrocarbons tended to occur in pore groundwater with a high concentration of either SO42- or Cl-.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Zhao, B; Huang, FY; Zhang, C; Huang, GX; Xue, Q; Liu, F or concate me.. Application In Synthesis of 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article KinFragLib: Exploring the Kinase Inhibitor Space Using Subpocket-Focused Fragmentation and Recombination WOS:000608875100049 published article about MEDICINAL CHEMISTRY; PROTEIN-KINASES; DRUG DISCOVERY; DESIGN; POWERFUL; DATABASE; MUTANT; KLIFS in [Sydow, Dominique; Schmiel, Paula; Volkamer, Andrea] Charite, Inst Physiol, Silico Toxicol & Struct Bioinformat, D-10117 Berlin, Germany; [Mortier, Jeremie] Bayer AG, Digital Technol Computat Mol Design, D-13342 Berlin, Germany in 2020, Cited 49. Safety of 2-Chloro-6-methylaniline. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

Protein kinases play a crucial role in many cell signaling processes, making them one of the most important families of drug targets. In this context, fragment-based drug design strategies have been successfully applied to develop novel kinase inhibitors. These strategies usually follow a knowledge-driven approach to optimize a focused set of fragments to a potent kinase inhibitor. Alternatively, KinFragLib explores and extends the chemical space of kinase inhibitors using data-driven fragmentation and recombination. The method builds on available structural kinome data from the KLIFS database for over 2500 kinase DFG-in structures cocrystallized with noncovalent kinase ligands. The computational fragmentation method splits the ligands into fragments with respect to their 3D proximity to six predefined functionally relevant subpocket centers. The resulting fragment library consists of six subpocket pools with over 7000 fragments, available at https://github.com/volkamerlab/KinFragLib. KinFragLib offers two main applications: on the one hand, in-depth analyses of the chemical space of known kinase inhibitors, subpocket characteristics, and connections, and on the other hand, subpocket-informed recombination of fragments to generate potential novel inhibitors. The latter showed that recombining only a subset of 624 representative fragments generated 6.7 million molecules. This combinatorial library contains, besides some known kinase inhibitors, more than 99% novel chemical matter compared to ChEMBL and 63% molecules compliant with Lipinski’s rule of five.

About 2-Chloro-6-methylaniline, If you have any questions, you can contact Sydow, D; Schmiel, P; Mortier, J; Volkamer, A or concate me.. Safety of 2-Chloro-6-methylaniline

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019.0 RUSS J PHYS CHEM A+ published article about ACID ORANGE 7; PHOTOCATALYTIC DEGRADATION; AZO-DYE; VISIBLE-LIGHT; METHYL-ORANGE; WATER; OPTIMIZATION; OXIDATION; CARBON in [Moradi, Reza] Islamic Azad Univ, Dept Chem, Tuyserkan Branch, Tuyserkan, Iran; [Ganjali, Amin] Islamic Azad Univ, Dept Expt Sci, Kahnooj Branch, Kahnooj, Iran in 2019.0, Cited 37.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6. Category: chlorides-buliding-blocks

In this paper, synthesized Fe3O4 nanoparticles applied as catalyst in photodegradation of Direct Red 23 (DR23) dye using photo-Fenton process in aqueous solution. The Fe3O4 nanoparticles were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Design of experiments (DOE) based on Taguchi approach was used. Analysis the response of each experiment was based Signal to Noise (S/N) ratio was calculated. The effective parameters for the degradation of dye were determined and optimized using Taguchi (L-9 (3(4))) orthogonal array experimental design method with four factors having three levels for each factor. The Taguchi approach showed that pH 3 (level 1), catalyst amount = 25 mg/L (level 2), H2O2 concentration = 15 ppm (level 3), and temperature = 35 degrees C (level 3) was optimum conditions for this process. The factor most influencing the process was determined using analysis of variance (ANOVA) method. The most significant factor in this process was pH. The interaction between pH x catalyst amount was the most influencing interaction. The percent (p (%)) of each factor on the degradation of dye was found to be in the following the order: pH (50.306%), catalyst amount (6.887%), H2O2 concentration (39.272%), and temperature (3.456%). The percentage contribution of factors in this process was found to be in the following the order: pH (0.332), catalyst amount (0.101), H2O2 concentration (0.291), and temperature (0.082). So first order reaction with k = 0.0472 min(-1) was observed for the photocatalytic degradation reaction.

Category: chlorides-buliding-blocks. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Moradi, R; Ganjali, A or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Photo-Induced Chloride Atom Transfer Radical Addition and Aminocarbonylation Reactions WOS:000478600900001 published article about ARYL CHLORIDES; METAL-FREE; ALKENES; ATRA; CYCLIZATION; ALKYNES; INITIATOR; BONDS in [Pan, Hao; Ge, Huaqi; He, Rong; Huang, Weichao; Wang, Lele; Wei, Yingcong; Yuan, Rusheng] Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350108, Fujian, Peoples R China; [Sa, Rongjian] Minjiang Univ, Ocean Coll, Inst Oceanog, Fuzhou 350108, Fujian, Peoples R China; [Wang, Yan-Jie] Dongguan Univ Technol, Sch Environm & Civil Engn, Dongguan 523808, Peoples R China in 2019.0, Cited 40.0. Product Details of 95-49-8. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

A photo-induced atom transfer radical addition (ATRA) of aryl chlorides onto alkenes has been developed in the synthesis of chloroalkyl benzenes, in which chlorine radicals and aryl radicals can be generated simultaneously at ambient temperature without the involvement of any initiator or catalyst. The inherently reactive and energetic chlorine radicals also benefit a photo-induced aminocarbonylation reaction of aryl chlorides with carbon monoxide and amines via a hydrogen-abstraction step. These two reactions can provide an inspiration for organic reaction with a radical-designed process. Finally, a photo-induced multi-phase reaction system is extended to flow mode to yield scaled-up products on a gram scale.

Product Details of 95-49-8. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Pan, H; Ge, HQ; He, R; Huang, WC; Wang, LL; Wei, YC; Sa, RJ; Wang, YJ; Yuan, RS or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article The aqueous solubility of common organic groundwater contaminants as a function of temperature between 5 and 70 degrees C WOS:000456223500020 published article about THERMAL-ENERGY STORAGE; POLYCYCLIC AROMATIC-HYDROCARBONS; WATER; DEPENDENCE; LIQUIDS; CHLOROBENZENES; COEFFICIENTS; DISSOLUTION; MOBILITY; BENZENE in [Koproch, Nicolas; Dahmke, Andreas; Koeber, Ralf] Univ Kiel, Appl Geosci, Ludewig Meyn Str 10, D-24118 Kiel, Germany in 2019.0, Cited 42.0. Recommanded Product: 95-49-8. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

High-temperature thermal energy storage in shallow aquifers can potentially increase ambient groundwater temperatures up to 70 degrees C or even more. Since an increase in temperature is expected to influence contaminant mass flux into groundwater monitoring the spreading of organic contaminants located in the subsurface is crucial. In numerous former studies, the NAPL solubility, one major parameter controlling mass flux on field scale, was measured at temperatures up to 70 degrees C for a broad spectrum of organic substances. However, quantitative calculations of solubilities as a function of temperature considering a compiled database are largely missing. Aiming to examine the reliability of existing solubility-temperature relationships, to describe them functionally and further to identify knowledge gaps, previously published data on solubilities of 42 different organic groundwater contaminants were evaluated in this study. By using a common temperature regression function, the calculated solubility curves from compiled solubility data for 5-70 degrees C show relative changes between a few percent (CHCs and BTEX) and up to 2000% (PAH5). As published temperature-dependent solubilities for chlorinated ethylenes are contradictory in parts, solubilities of tetrachloroethylene, trichloroethylene, 1,2-cis-dichloroethylene and 1,2-trans-dichloroethylene were additionally investigated in more detail using batch experiments between 5 and 70 degrees C. The results show distinctive solubility minima at medium temperatures (20-40 degrees C) with concentrations decreasing from 5 degrees C to the minimum by 10-20%. The measured and calculated temperature-dependent solubilities enable a more reliable assessment of thermal energy storage at contaminated sites, of existing thermal remediation approaches and of combinations of underground heat storage with groundwater remediation. (C) 2018 Elsevier Ltd. All rights reserved.

Recommanded Product: 95-49-8. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Koproch, N; Dahmke, A; Kober, R or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 95-49-8. I found the field of Chemistry very interesting. Saw the article Nickel-Catalyzed Hydroarylation of Alkynes under Reductive Conditions with Aryl Bromides and Water published in 2019, Reprint Addresses Wilger, DJ (corresponding author), Samford Univ, Dept Chem & Biochem, Birmingham, AL 35229 USA.. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene.

An operationally simple nickel-catalyzed hydroarylation reaction for alkynes is described. This three component coupling reaction utilizes commercially available alkynes and aryl bromides, along with water and Zn. An air-stable and easily synthesized Ni(II) precatalyst is the only entity used in the reaction that is not commercially available. This reductive cross-coupling reaction displays a fairly unusual anti selectivity when aryl bromides with ortho substituents are used. In addition to optimization data and a preliminary substrate scope, complementary experiments including deuterium labeling studies are used to provide a tentative catalytic mechanism. We believe this report should inspire and inform other Ni-catalyzed carbofunctionalization reactions.

Recommanded Product: 95-49-8. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Barber, ER; Hynds, HM; Stephens, CP; Lemons, HE; Fredrickson, ET; Wilger, DJ or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Chemical conversion of nicotinamide into type I positive allosteric modulator of alpha 7 nAChRs WOS:000471750200013 published article about ACETYLCHOLINE-RECEPTOR AGONIST; PHARMACOLOGICAL CHARACTERIZATION; IDENTIFICATION; APOPTOSIS; SUBUNIT; RELEASE in [Li, Xin; Xie, Wenjun; Huang, Zongze; Sun, Qi] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Xie, Wenjun; Wang, Xintong; Bian, Xiling; Wang, KeWei] Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China; [Wang, KeWei] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao 266021, Shandong, Peoples R China in 2019, Cited 38. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8. Application In Synthesis of 2-Chloro-6-methylaniline

Structural modifications of nicotinamide, a form of vitamin B3, gave rise to a series of compounds (8aa-8ce) that exhibit activities as type I positive allosteric modulators (PAMs) of human alpha 7 nAChR expressed in Xenopus oocytes in two-electrode voltage clamp assay. The compound 8ai was a potent and efficacious PAM with an EC50 = 3.34 +/- 1.13 mu M and the maximum activation effect of alpha 7 current over 1474 +/- 246% in the presence of acetylcholine (100 mu M). It is highly specific to alpha 7 nAChR over other subtypes of nAChR and 5-HT3A receptors. The structure-activity relationship analysis identified a key skeleton of nicotinamide nucleus critical for biological activity. Taken together, the 8ai as a type I PAM of alpha 7 nAChR may be beneficial for improvement of cognitive deficit.

About 2-Chloro-6-methylaniline, If you have any questions, you can contact Li, X; Xie, WJ; Wang, XT; Huang, ZZ; Bian, XL; Wang, KW; Sun, Q or concate me.. Application In Synthesis of 2-Chloro-6-methylaniline

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019.0 ACS CATAL published article about RING-OPENING POLYMERIZATION; PHOTOSWITCHABLE CATALYSIS; TRANSFER HYDROGENATION; LEWIS-ACID; LIGHT; COMPLEX; RUTHENIUM; CHEMISTRY; COPOLYMERIZATION; NANOPARTICLES in [Sarmah, Kasturi; Mukhopadhyay, Subhamoy; Maji, Tarun K.; Pratihar, Sanjay] Tezpur Univ, Dept Chem Sci, Napaam 784028, Assam, India in 2019.0, Cited 75.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. SDS of cas: 95-49-8

Herein we disclosed the utilization of copper loaded zinc oxide (ZnO-Cu) for its stimuli (O-2/light) responsive switchable performance between its reduced (S-1) and oxidized (S-2) state for two antagonistic reactions, namely oxidation of alkyl arenes/heteroarenes to aldehydes/ketones and reduction of nitro arenes/heteroarenes corresponding amines. The two states of the catalyst showed its switchable performance as highly active and poorly active catalyst for oxidation and reduction, and both reactions could be turned off and on by changing the stimuli (light and O-2/N-2). The switching efficiency between the states and their relative reactivity were found to be consistent under variety of reaction conditions and remain unaltered irrespective of oxidation-reduction (or vice versa) sequence and substrates used in the reaction. The photo catalysts (S-1 and S-2) demonstrated good catalytic activity, multiple reusability, broad substrate scope, and reasonable functional group tolerance for both the reactions and probed its quality performance in a large-scale setup. The system was used in an assisted tandem catalysis setup for the synthesis of benzyl amines utilizing both oxidation and reduction reaction by stimuli responsive switching between the states of the catalyst.

SDS of cas: 95-49-8. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Sarmah, K; Mukhopadhyay, S; Maji, TK; Pratihar, S or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Authors Chang, RK; Clairmont, BP; Lin, S; MacArthur, AHR in AMER CHEMICAL SOC published article about N-ARYLATION; (HETERO)ARYL CHLORIDES; HALIDES; LIGANDS; AMIDES; LACTAMS in [Chang, Raymond K.; Clairmont, Brice P.; Lin, Shirley; MacArthur, Amy H. Roy] US Naval Acad, Dept Chem, 572 Holloway Rd, Annapolis, MD 21402 USA in 2019.0, Cited 34.0. Safety of 1-Chloro-2-methylbenzene. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

A concurrent tandem catalytic (CTC) methodology has been developed for the amidation of aryl chlorides where the aryl chloride is first converted to an aryl iodide via halogen exchange and the aryl iodide is subsequently transformed into the aryl amide. A variety of aryl chlorides were converted to aryl amides in up to 85% isolated yield using 20 mol % CuI, 60 mol % N,N’-cyclohexane-1,2-diamine, 2.2 equiv of K2CO3, and 1.05-1.5 equiv of amide in acetonitrile at 200 degrees C after 0.75-1 h. The same copper/ligand system served as multifunctional catalyst for both steps of the concurrent catalytic process with iodide present in substoichiometric amounts. Mechanistic studies were consistent with CTC amidation occurring via a nonradical mechanism. Kinetic modeling was conducted to investigate the effect of competitive direct amidation of an aryl chloride or aryl bromide on the formation of product over time during a CTC amidation reaction.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Chang, RK; Clairmont, BP; Lin, S; MacArthur, AHR or concate me.. Safety of 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics