SDS of cas: 50-84-0. Recently I am researching about PHYTOPHTHORA-CAPSICI; BLACK SHANK; OXATHIAPIPROLIN; STROBILURINS; METALAXYL; EFFICACY; DOCKING; CYP51, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31571991, 31872007]; International Science & Technology Cooperation Program of China [2014DFR41030]; Tianjin Natural Science FoundationNatural Science Foundation of Tianjin [18JCZDJC33500]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M611156]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wu, QF; Zhao, B; Fan, ZJ; Guo, XF; Yang, DY; Zhang, NL; Yu, B; Zhou, S; Zhao, JB; Chen, F. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid
Oxathiapiprolin is one of the best active fungicides discovered for oomycetes control. To develop a fungicide candidate with a broad spectrum of activity, 22 new piperidinylthiazole derivatives were designed and synthesized. Compound 51 showed the best activity against Pseudoperonospora cubensis (Berk. et Curt.) Rostov and Phytophthora infestans in vivo with 100% and 80% of inhibition, respectively, at 1 mg/L, and 72.87% of field efficacy against P. cubensis at 1 g ai/667 m(2) validated these results. Compound 5i exhibited a broad spectrum of excellent activity against Sclerotinia sclerotiorum with EC50 = 0.30 mg/ L (>10 times more active than oxathiapiprolin and azoxystrobin in vitro), good activity against Botrytis cinerea, Cercospora arachidicola, and Gibberella zeae with EC50 of 14.54, 5.57, and 14.03 mg/L in vitro and against P. cubensis and P. infestans with 60% and 30% inhibition rates, respectively, at 1 mg/L in vivo. Mode of action studies by RNA sequencing analysis discovered oxysterol-binding protein (OSBP), chitin synthase (CHS1), and (1,3)-beta-glucan synthase (FKS2) as the potent target of 5i against S. sclerotiorum. Quenching studies validated that OSBP was the same target of both 5i and oxathiapiprolin; it was quenched by both of them. Our studies discovered isothiazole-containing piperidinylthiazole as an OSBP target-based novel lead for fungicide development.
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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics