Recently I am researching about NUCLEAR RECEPTOR; ACCURATE DOCKING; DIFFERENTIATION; MODULATORS; ALPHA; ANTAGONISTS; INTERFACE; DISCOVERY; PROGRAM; PHASE, Saw an article supported by the Netherlands Organization for Scientific Research through Gravity program [024.001.035]; Netherlands Organization for Scientific Research through VICI grantNetherlands Organization for Scientific Research (NWO) [016.150.366]; Netherlands Organization for Scientific Research through ECHO grantNetherlands Organization for Scientific Research (NWO) [711.018.003]; European Union through a MSCA Individual Fellowship [705188]. Application In Synthesis of 2,6-Dichlorobenzoic acid. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Meijer, FA; Doveston, RG; de Vries, RMJM; Vos, GM; Vos, AAA; Leysen, S; Scheepstra, M; Ottmann, C; Milroy, LG; Brunsveld, L. The CAS is 50-30-6. Through research, I have a further understanding and discovery of 2,6-Dichlorobenzoic acid
Retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) is a nuclear receptor associated with the pathogenesis of autoimmune diseases. Allosteric inhibition of ROR gamma t is conceptually new, unique for this specific nuclear receptor, and offers advantages over traditional orthosteric inhibition. Here, we report a highly efficient in silico-guided approach that led to the discovery of novel allosteric ROR gamma t inverse agonists with a distinct isoxazole chemotype. The the most potent compound, 25 (FM26), displayed submicromolar inhibition in a coactivator recruitment assay and effectively reduced IL-17a mRNA production in EM cells, a marker of ROR gamma t activity. The projected allosteric mode of action of 25 was confirmed by biochemical experiments and cocrystallization with the ROR gamma t ligand binding domain. The isoxazole compounds have promising pharmacokinetic properties comparable to other allosteric ligands but with a more diverse chemotype. The efficient ligand-based design approach adopted demonstrates its versatility in generating chemical diversity for allosteric targeting of ROR gamma t.
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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics