I found the field of Chemistry very interesting. Saw the article Solvent-Dependent Chemoselective and Stereoselective Approach to Synthesis of Spiro-gamma-Lactams with Potent Anticancer Activity published in 2021. SDS of cas: 50-84-0, Reprint Addresses Chen, ZZ; Xu, ZG (corresponding author), Chongqing Univ Arts & Sci, Coll Pharm, Natl & Local Joint Engn Res Ctr Targeted & Innova, IATTI, Chongqing 402160, Peoples R China.; Li, HY (corresponding author), Univ Arkansas Med Sci, Dept Pharmaceut Sci, Coll Pharm, Little Rock, AR 72205 USA.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid
Chemoselective approaches were developed for derivatizing diastereoselective chromanone spiro-gamma-lactams through the Michael-type addition by using amide as a weak nucleophile to construct the spiro-carbon center under basic conditions. To expand the scope of this post-Ugi cascade reaction, a new series of oxidized chromone derivatives was synthesized by altering solvent from EtOH to DMF. Compounds 7 a and 7 b which could be synthesized in one day, demonstrated comparable anticancer activities with legendary anticancer drug paclitaxel in the PANC and U87 cell lines. This methodology offers a new approach to construct spiro-carbon centers with functionalized chromanones or chromones under mild reaction conditions.
Welcome to talk about 50-84-0, If you have any questions, you can contact Lei, J; He, LJ; Tang, DY; Wen, JY; Yan, W; Li, HY; Chen, ZZ; Xu, ZG or send Email.. SDS of cas: 50-84-0
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics