Month: March 2022

SDS of cas: 12266-72-7. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Heteropolytopic phosphanylarylthiolato ligands: formation of cis isomers of nickel(II), palladium(II) and platinum(II) complexes with 1-P(Biph)-2-SHC6H4 (Biph = 1,1′-biphenyl-2,2′-diyl). Author is Hildebrand, Alexandra; Sarosi, Imola; Loennecke, Peter; Silaghi-Dumitrescu, Luminita; Sarosi, Menyhart B.; Silaghi-Dumitrescu, Ioan; Hey-Hawkins, Evamarie.

Reaction of the ditopic phosphanylarylthiol 1-P(Biph)-2-SHC6H4 (BiphPSH, Biph = 1,1′-biphenyl-2,2′-diyl), prepared by lithiation-electrophilic substitution, with NiCl2·6H2O, Na2[PdCl4] and [PtI2(cod)] (cod = 1,5-cyclooctadiene) in a 2:1 ratio and in the presence of NEt3 gave exclusively cis isomers of the square-planar complexes cis-[M{(1-P(Biph)-2-S-C6H4)-κ2S,P}2] ([M{(BiphPS)-κ2S,P}2]; M = Ni (1), Pd (2), Pt (3)). D. functional calculations support the assumption that this is probably due to intramol. π-π interaction of the biphenyl groups, which results in enhanced stability of the cis isomers. Compound 1 is the first example of a structurally characterized mononuclear cis-bis(phosphanylthiolato)nickel(II) complex. Small amounts of trinuclear [{PtI(1-P(Biph)-μ-2-S-C6H4-κ2S,P)}3] (4) are also formed besides the mononuclear Pt bis-chelate complex 3.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 12266-72-7. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Platinum(II) complexes of the tridentate thioether ligands RS(CH2)3S(CH2)3SR (R = Et, iPr, Ph). Structures of [PtCl(iPrS(CH2)3S(CH2)3SiPr)][BF4], [PtI(PhS(CH2)3S(CH2)3SPh)][BF4], and [Pt(PPh3)(iPrS(CH2)3S(CH2)3SiPr)][BF4]2·CH2Cl2.

The tridentate thioether ligands RS(CH2)3S(CH2)3SR (L1, R = Et; L2, R = iPr, L3, R = Ph) were synthesized by nucleophilic addition of thiolate, SR-, to the ditosylate TsO(CH2)3S(CH2)3OTs. [PtX(Ln)][BF4] were prepared by displacement of 1,5-COD from [PtX2(1,5-COD)] (X = Cl, I) in the presence of one equivalent of AgBF4 and one equivalent of thioether ligand. [PtCl(L2)][BF4] crystallized in the monoclinic space group P21/c with a 10.409(6), b 14.180(4), c 13.726(8) Å, β 104.49(4)°, and Z = 4. The structure refined to R = 5.62% and Rw = 6.86% for 2121 reflections with F°2 > 3σ(F°2). [PtI(L3)][BF4] crystallized in the monoclinic space group P21/n with a 13.415(4), b 12.350(5), c 14.316(5) Å, β 107.48(3)°, and Z = 4. The structure refined to R = 4.85% and Rw = 6.33% for 2168 reflections with F°2 > 3σ(F°2). In both compounds, the thioether ligand acts as a tridentate chelator occupying three of the four sites of the square-planar Pt(II) complex. Variable temperature 13C{1H} NMR verified that there are three possible stereoisomers for these complexes resulting from inversion at S: meso-A, meso-B, and racemic. Thermodn. parameters were calculated for the interconversion among isomers of [PtCl(L2)][BF4] by a full line-shape anal. Removal of the chloride ligand from [PtCl(L2)][BF4] with Ag+ in the presence of PPh3 yielded the phosphine adduct [Pt(PPh3)(L2)][BF4]2, which crystallized in the triclinic space group P1̅ with a 13.266(3), b 11.315(2), c 13.970(2) Å, α 106.04(2), β 84.95(2), γ 86.56(2)°, and Z = 2. The structure refined to R = 4.22% and Rw = 5.38% for 4493 reflections with F°2 > 3σ(F°2). Unlike the two halide complex structures, which crystallized in the meso-B form, [Pt(PPh3)(L2)][BF4]2 crystallized in the racemic form.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C11H18O. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Hexabromoacetone and ethyl tribromoacetate: a highly efficient reagent for bromination of alcohol. Author is Tongkate, Pratoomrat; Pluempanupat, Wanchai; Chavasiri, Warinthorn.

A new and efficient method for the bromination of alcs. utilizing Br3CCOCBr3/PPh3 and Br3CCO2Et/PPh3 is described. Various alcs. can be converted smoothly into their corresponding alkyl bromides in high yields under mild conditions with short reaction times. Based upon 1H NMR studies using competitive reactions between selected brominating agents and Cl3CCN, Br3CCOCBr3 displays the highest reactivity approx. 9 times that of CBr4.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 1968-05-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Indole-3-carbinol derivative DIM mitigates carbon tetrachloride-induced acute liver injury in mice by inhibiting inflammatory response, apoptosis and regulating oxidative stress.

3,3′-Diindolylmethane (DIM), a metabolic product of indole-3-carbinol extracted from cruciferous vegetables exhibits anti-inflammatory and anti-cancer properties. Earlier, the product has been demonstrated to possess anti-fibrotic properties; however, its protective effects on liver injury have not been clearly elucidated. In this study, we postulated the effects and mol. mechanisms of action of DIM on carbon tetrachloride (CCl4)-induced liver injury in mice. Acute liver injury was induced by a single i.p. administration of CCl4 (1 mL/kg) into mice. DIM was injected via s.c. route for three days at various doses (2.5, 5 and 10 mg/kg) before CCl4 injection. Mice were sacrificed and serum was collected for quantification of serum transaminases. The liver was collected and weighed. Treatment with DIM significantly reduced serum transaminases levels (AST and ALT), tumor necrosis factor-α (TNF-α) and reactive oxygen species (ROS). CCl4- induced apoptosis was inhibited by DIM treatment by the reduction in the levels of cleaved caspase-3 and Bcl2 associated X protein (Bax). DIM treated mice significantly restored Cytochrome P 450 2E1, nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression in CCl4 treated mice. In addition, DIM downregulated overexpression of hepatic nuclear factor kappa B (NF-κB) and inhibited CCl4 mediated apoptosis. Our results suggest that the protective effects of DIM against CCl4- induced liver injury are due to the inhibition of ROS, reduction of pro-inflammatory mediators and apoptosis.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 498-95-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about Introduction of Cyclopropyl and Cyclobutyl Ring on Alkyl Iodides through Cobalt-Catalyzed Cross-Coupling.

A cobalt-catalyzed cross-coupling between alkyl iodides and cyclopropyl, cyclobutyl, and alkenyl Grignard reagents is disclosed. The reaction allows the introduction of strained rings on a large panel of primary and secondary alkyl iodides. The catalytic system is simple and nonexpensive, and the reaction is general, chemoselective, and diastereoconvergent. The alkene resulting from the cross-coupling can be transformed to substituted cyclopropanes using a Simmons-Smith reaction. The formation of radical intermediates during the coupling is hypothesized.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about A C2 Fragment as Four-Electron σ Donor.Safety of Diiodo(1,5-cyclooctadiene)platinum(II).

The formation and x-ray structure anal. of the PtIV complex [(CH2C{PPh2C6H4}2)PtI2] is reported. The mol. possesses the orthometalated ligand (PPh3)2C→CH2, which serves via its C2 fragment as an unprecedented four-electron σ donor.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4144-22-3, is researched, SMILESS is O=C(C=C1)N(C(C)(C)C)C1=O, Molecular C8H11NO2Journal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Cross-Coupling of Acrylamides and Maleimides under Rhodium Catalysis: Controlled Olefin Migration, Author is Sharma, Satyasheel; Han, Sang Hoon; Oh, Yongguk; Mishra, Neeraj Kumar; Lee, Suk Hun; Oh, Joa Sub; Kim, In Su, the main research direction is acrylamide maleimide cross coupling reaction rhodium catalysis olefin migration; succinimide substituted preparation.Electric Literature of C8H11NO2.

The rhodium(III)-catalyzed direct cross-coupling reaction of electron-deficient acrylamides with maleimides is described. This protocol displays broad functional group tolerance and high efficiency, which offers a new opportunity to access highly substituted succinimides. Dependent on the substituent positions of acrylamides and reaction conditions, olefin migrated products were obtained with high regio- and stereoselectivity.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Diiodo(1,5-cyclooctadiene)platinum(II)(SMILESS: I[Pt]I.C1=CCC/C=CCC/1,cas:12266-72-7) is researched.Formula: C12H12N2. The article 《Molecular recognition – allosterism generated by weak host-guest interactions in molecular rectangles》 in relation to this compound, is published in European Journal of Inorganic Chemistry. Let’s take a look at the latest research on this compound (cas:12266-72-7).

Two metal-based mol. rectangles (for example, I) that bear two identical binding sites form host-guest adducts with analogous planar Pt2+ complexes (for example, II and III). The larger of the guests III shows no binding allosterism with either of the two rectangles but substantial pos. allosterism is observed when the smaller guest II binds to the rectangles. It is proposed that the smaller guest is better accommodated in the binding sites of the receptor and that this leads to allosterism. Various experiments including 1H NOESY spectroscopy support the supposition that the smaller guest is better incarcerated in the receptors. The mol. structure of the 1:2 host-guest adduct of I:III was determined by X-ray crystallog.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Incorporation of 3,3′-Diindolylmethane into Nanocapsules Improves Its Photostability, Radical Scavenging Capacity, and Cytotoxicity Against Glioma Cells, published in 2019-02-28, which mentions a compound: 1968-05-4, Name is 3,3′-Diindolylmethane, Molecular C17H14N2, Related Products of 1968-05-4.

3,3′-Diindolylmethane (DIM) is a phytochem. that presents health benefits (antitumor, antioxidant, and anti-inflammatory effects). However, it is water insoluble and thermo- and photolabile, restraining its pharmaceutical applications. As a strategy to overcome such limitations, this study aimed the development and characterization of DIM-loaded nanocapsules (NCs) prepared with different compositions as well as the in vitro assessment of scavenging activity and cytotoxicity. The formulations were obtained using the interfacial deposition of preformed polymer method and were composed by Eudragit RS100 or ethylcellulose as polymeric wall and primula or apricot oil as the core. All the formulations had adequate physicochem. characteristics: nanometric size (around 190 nm), low polydispersity index (< 0.2), pH value at acid range, high values of zeta potential, drug content, and encapsulation efficiency (∼ 100%). Besides, nanoencapsulation protected DIM against UVC-induced degradation and increased the scavenging activity assessed by the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) and 1-1-diphenyl-2-picrylhydrazyl methods. The developed DIM-loaded nanocapsules were further evaluated regarding the in vitro release profile and cytotoxicity against a human glioblastoma cell line (U87 cells). The results demonstrated that the nanoencapsulation promoted a sustained release of the bioactive compound (in the range of 58-78% after 84 h) in comparison to its free form (86% after 12 h), as well as provided a superior cytotoxic effect against the U87 cells in the highest concentrations Therefore, our results suggest that nanoencapsulation could be a promising approach to overcome the DIM physicochem. limitations and potentialize its biol. properties. There is still a lot of research devoted to this compound(SMILES：C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4)Related Products of 1968-05-4, and with the development of science, more effects of this compound(1968-05-4) can be discovered.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Photoinduced polymerization of monofunctional maleimides and donor monomers. Author is Clark, S. C.; Doucet, G. J.; Joensson, S.; Mattson, G. A.; Hoyle, C. E..

The inherent reactivity of a maleimide/donor formulation was established by polymerizing in the presence of a photoinitiator, e.g., 2,2-dimethoxy-2-phenylacetophenone. Donors, e.g, N-vinylpyrrolidone and N-Me vinylacetamide, were polymerized with maleimides, e.g., tert-butylmaleimide (I) and 2-ethylcarbonate ethylmaleimide (II). II had a greater reactivity with the corresponding donor monomers than I.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics