The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8 ) is researched.Application of 35836-73-8.Akgun, Burcin; Hall, Dennis G. published the article 《Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation》 about this compound( cas:35836-73-8 ) in Angewandte Chemie, International Edition. Keywords: boronate formation click bioorthogonal conjugation protein; bioorthogonality; boronates; boronic acids; click chemistry; protein labeling. Let’s learn more about this compound (cas:35836-73-8).
A new click bioorthogonal reaction system was devised to enable the fast ligation (kON ≈ 340 M-1 s-1) of conjugatable derivatives of a rigid cyclic diol (nopoldiol) and a carefully optimized boronic acid partner, 2-methyl-5-carboxymethylphenylboronic acid. Using NMR and fluorescence spectroscopy studies, the corresponding boronates form reversibly within minutes at low micromolar concentration in water, providing submicromolar equilibrium constant (Keq≈105-106 M-1). Efficient protein conjugation under physiol. conditions was demonstrated with model proteins thioredoxin and albumin, and characterized by mass spectrometry and gel electrophoresis.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics