HPLC of Formula: 1968-05-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Anti-osteoclastogenic Effects of Indole Alkaloids Isolated from Barley (Hordeum vulgare Var. Hexastichon) Grass. Author is Ha, Manh Tuan; Tran, Phuong Thao; Tran, Huynh Nguyen Khanh; Kim, Okwha; Kim, Jeong Ah; Lee, Jeong-Hyung; Min, Byung Sun.
As part of our continuous program to identify new potential candidates for controlling osteolytic bone diseases from natural products, the alkaloid fraction of barley (Hordeum vulgare var. hexastichon) grass (HVA) significantly inhibited RANKL-induced osteoclast formation and protected mice from LPS-induced bone loss. A phytochem. investigation of HVA afforded nine indole alkaloids, including one new compound [hordeumin A (1)] and eight known analogs (2-9). Of them, four (1, 2, 4, and 5) were anti-osteoclastogenic compounds Of these four, compound 5 significantly suppressed RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner. It also suppressed the RANKL-induced NF-κB and MAPK signaling pathways and the activation of c-Fos and NFATc1. Compound 5 also reduced the expression levels of osteoclast-specific marker genes, including TRAP, CtsK, DC-STAMP, OSCAR, and MMP9. Our findings suggest that HVA and its alkaloid constituents could be valuable candidates for the prevention and treatment of osteolytic bone diseases.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics