Mattiazzi, Juliane; Marcondes Sari, Marcel Henrique; Brum, Taine de Bastos; Araujo, Paulo Cesar Oliveira; Nadal, Jessica Mendes; Farago, Paulo Vitor; Nogueira, Cristina Wayne; Cruz, Leticia published an article about the compound: 3,3′-Diindolylmethane( cas:1968-05-4,SMILESS:C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4 ).SDS of cas: 1968-05-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1968-05-4) through the article.
This study aimed to characterize the physicochem. properties of (DIM)-loaded (NCs) as well as the antinociceptive effect using distinct animal models (hot plate test, formalin-induced nociception and complete Freud’s adjuvant induced paw inflammation). The physicochem. characterization demonstrated that DIM could be molecularly dispersed into the NCs, whose size was nanometric with a spherical shape. An improvement in thermal stability was achieved by its encapsulation and there were no interactions among the formula components. For the nociceptive evaluation, male adult Swiss mice were pretreated with the NCs or free DIM by the intragastric route at the dose of (time-response curve), (dose-response curve). Both free and nanoencapsulated DIM reduced the mech. hypernociception induced by CFA, mitigated nociceptive behavior of formalin-induced neurogenic and inflammatory pain and increased paw withdrawal latency assessed by the hot-plate test. Importantly, the nanoencapsulation promoted a rapid initiation and prolonged the bioactive antinociceptive action as well as reduced the ED in comparison to its free form. In summary, this study reported that the NCs had adequate nanometric size, increased DIM stability and its antinociceptive action in different animal models, suggesting that the formulation may be a possible therapeutic alternative to the management of pain and inflammatory-related pathologies.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics