Month: March 2022

Application In Synthesis of 3,3′-Diindolylmethane. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3′-diindolylmethane ligand. Author is Dankhoff, Katja; Ahmad, Aamir; Weber, Birgit; Biersack, Bernhard; Schobert, Rainer.

In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a new bis(triethylammonium) tris[1,1-bis(indol-3-yl)-1-(3,4-catecholate)methane]vanadate(IV) complex. It exhibited significant antiproliferative activity against various cancer cell lines, showed a stronger DNA binding than cisplatin and led to mitochondrial damage, a formation of reactive oxygen species, and a cell cycle arrest in the G2/M phase of cancer cells.

There is still a lot of research devoted to this compound(SMILES：C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4)Application In Synthesis of 3,3′-Diindolylmethane, and with the development of science, more effects of this compound(1968-05-4) can be discovered.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Fles, D. D.; Hace, D.; Ranogajec, F.; Vukovic, R.; Fles, D. researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).Computed Properties of C8H11NO2.They published the article 《The application of Taft-Hancock steric constants to the free-radical initiated copolymerization of N-alkylmaleimides with α-methylstyrene》 about this compound( cas:4144-22-3 ) in Polymer Bulletin (Berlin). Keywords: methylstyrene polymerization kinetics alkylmaleimide; steric constant alkylmaleimide polymerization methylstyrene; polar substituent constant polymerization alkylmaleimide. We’ll tell you more about this compound (cas:4144-22-3).

The rates of free-radical-initiated alternating copolymerization of α-methylstyrene with N-alkylmaleimides decrease in the following order: Me > Et > n-Pr ≈ n-Bu ≈ n-Hex > iso-Pr > tert-Bu. A linear relationship was established in the plots of log(kR/kMe) against the polar substituent constants, σ*, “”true steric”” factors, ES, and corrected steric factors, ESC. The best fit was obtained in plots of log (kR/kMe) vs. σ* and ESC whereas a large scattering of results was observed in the plot of log (kR/kMe) vs. ES.

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Name: Diiodo(1,5-cyclooctadiene)platinum(II). The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Bis-μ-[bis(diphenylphosphino)methane]-bis(halogenoplatinum)(Pt-Pt); dimeric complexes of platinum(I) containing a platinum-platinum bond. Author is Brown, Michael P.; Puddephatt, Richard J.; Rashidi, Mehdi; Seddon, Kenneth R..

Treatment of PtCl2L (L = Ph2PCH2PPh2) with NaBH4-MeOH followed by HCl-benzene gave the title complex (I; X = Cl). I (X = Br, I) were obtained from the chloro complex by halide exchange. Anal. of the 1H and 31P NMR and vibrational spectra of the complexes supported structure I rather than the halo-bridged structure reported by F. Glockling and R. J. I. Pollock (1974). Bands assigned to ν(Pt-Pt) are present in the Raman spectra.

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Min, Jaeki; Guo, Kexiao; Suryadevara, Praveen K.; Zhu, Fangyi; Holbrook, Gloria; Chen, Yizhe; Feau, Clementine; Young, Brandon M.; Lemoff, Andrew; Connelly, Michele C.; Kastan, Michael B.; Guy, R. Kiplin published an article about the compound: 4-Chloroquinazoline-6,7-diol( cas:1145671-36-8,SMILESS:OC1=CC2=C(Cl)N=CN=C2C=C1O ).Application of 1145671-36-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1145671-36-8) through the article.

We previously reported a novel inhibitor of the ataxia-telangiectasia mutated (ATM) kinase, which is a target for novel radiosensitizing drugs. While our initial lead, compound 4, was relatively potent and nontoxic, it exhibited poor stability to oxidative metabolism and relatively poor selectivity against other kinases. The current study focused on balancing potency and selectivity with metabolic stability through structural modification to the metabolized site on the quinazoline core. We performed extensive structure-activity and structure-property relationship studies on this quinazoline ATM kinase inhibitor in order to identify structural variants with enhanced selectivity and metabolic stability. We show that, while the C-7-methoxy group is essential for potency, replacing the C-6-methoxy group considerably improves metabolic stability without affecting potency. Promising analogs 20, 27g, and 27n were selected based on in vitro pharmacol. and evaluated in murine pharmacokinetic and tolerability studies. Compound 27g possessed significantly improve pharmacokinetics relative to that of 4. Compound 27g was also significantly more selective against other kinases than 4. Therefore, 27g is a good candidate for further development as a potential radiosensitizer.

If you want to learn more about this compound(4-Chloroquinazoline-6,7-diol)Application of 1145671-36-8, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1145671-36-8).

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Indole treatment alleviates intestinal tissue damage induced by chicken coccidiosis through activation of the aryl hydrocarbon receptor, the main research direction is coccidiosis indole aryl hydrocarbon receptor; CD4+ T cells; Th17 cells; Treg cells; chicken; coccidiosis; indole.Application of 1968-05-4.

In the present study, we examined the effects of dietary indoles, 3,3′-diindolylmethane (DIM) and indole-3-carbinol (I3C), on CD4+T cell population and functions in chickens. Furthermore, the effects of dietary DIM treatment on chicken coccidiosis caused by an apicomplexan parasite were investigated. Dietary treatment of healthy chickens with DIM and I3C induced increased CD4+CD25+ (Treg) cells and the mRNA expression of IL-10, while decreasing number of CD4+IL-17A+ (Th17) cells and Th17-related cytokines transcripts expression in the intestine. In addition, we explored the role of AhR in indole-treated splenic lymphocytes by using AhR antagonist and our results suggested that DIM is a ligand for chicken AhR. In chicken coccidiosis, treatment of DIM increased the ratio of Treg/Th17 cells and significantly reduced intestinal lesion although no significant changes in body weight and fecal oocyst production were noted compared to non-treated control group. These results indicate that DIM is likely to affect the ratios of Treg/Th17 reducing the level of local inflammatory response induced by Eimeria or facilitate repairing process of inflamed gut following Eimeria infection. The results described herein are thus consistent with the concept that AhR ligand modulates the T cell immunity through the alteration of Treg/Th17 cells with Treg dominance. To our knowledge, present study is the first scientific report showing the effects of dietary indole on T cell immunity in poultry species.

If you want to learn more about this compound(3,3′-Diindolylmethane)Application of 1968-05-4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1968-05-4).

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Chloride – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Facile intramolecular silicon-carbon bond activation at Pt0 and PtII centers, the main research direction is platinum silyl diphosphine complex preparation oxidative addition reductive elimination; crystal structure platinum pincer silyl diphosphine complex; mol structure platinum pincer silyl diphosphine complex.COA of Formula: C8H12I2Pt.

The compound (2-Cy2PC6H4)2SiMe2 (1) reacted readily with Pt(PPh3)4 to undergo Si-C(sp3) bond cleavage and form the PtII species (Cy-PSiP)PtMe [2, Cy-PSiP = (2-Cy2PC6H4-κP)2SiMe–κSi]. The silane 1 also undergoes Si-C(sp3) bond activation with the PtII precursor [(Me2S)PtMe2]2 to generate 2. Two intermediate species were observed in situ during the reaction of 1 with [(Me2S)PtMe2]2. One intermediate was tentatively assigned as the bis(phosphino) PtII species (κ2-Cy-PSiP)PtMe2 (4), which was crystallog. characterized. A second intermediate (5) was tentatively assigned as the PtIV species (Cy-PSiP)PtMe3 resulting from Si-C(sp3) bond cleavage in 4. In an effort to prepare a (Cy-PSiP)PtIV species that may serve as a model for 5, complex 2 was reacted with MeI and I2, resp.; both reactions resulted in the quant. formation of the Pt(II) complex [(Cy-PSiP)PtI] (6), which could also be independently prepared by the reaction of (COD)PtI2 with (Cy-PSiP)H. The reaction of (Cy-PSiP)H with PtMe3I resulted in the formation of a PtIV species (7) as the major product. Complex 7 was tentatively assigned as (Cy-PSiP)PtMe2I, and undergoes relatively facile reductive elimination of ethane to form 6.

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Chlorides – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR-miR-429 pathway, the main research direction is tetrandrine intestinal epithelial colitis Occludin AhR miR 429; Occludin; aryl hydrocarbon receptor; colitis; intestinal epithelial barrier; tetrandrine.Name: 3,3′-Diindolylmethane.

The elevated intestinal permeability due to mucosal barrier defects is not only secondary to inflammatory bowel disease but also precedes enteritis. Tetrandrine, a bisbenzyl isoquinoline alkaloid isolated from the dried roots of Stephamis tetlandra S. Moor, was previously demonstrated to ameliorate colitis induced by dextran sulfate sodium (DSS) in mice. Here, we investigate whether and how tetrandrine protects against the disruption of the intestinal epithelial barrier under colitis condition. The data show that oral administration of tetrandrine significantly counteracted the increase of intestinal permeability in DSS-treated mice, enhanced the mRNA and protein expression of Occludin and Claudin1 in the colon, but hardly affected the expression of ZO-1 and Mucin2. In vitro, tetrandrine treatment rescued the decrease of monolayer transmembrane resistance and the increase of epithelial cell permeability induced by TNF-α, upregulated the expression of Occludin, and downregulated the expression of Claudin1 but did not affect the expression of ZO-1. The siRNA of Occludin largely weakened the protective effect of tetrandrine on the epithelial barrier function in Caco-2 cells. MiR-429 mimic obviously counteracted the upregulation of tetrandrine on the expression of Occludin and the amelioration on epithelial barrier defects, in contrast, miR-429 inhibitor showed the opposite effects. The antagonist (CH223191) and siAhR of aryl hydrocarbon receptor (AhR) nearly completely diminished the effects of tetrandrine, including inhibition of the miR429 expression, the upregulation of Occludin expression, and amelioration of intestinal epithelial barrier defects in Caco-2 cells. In colitis mice, CH223191 significantly weakened the protective effect of tetrandrine on colitis and intestinal mucosal barrier and diminished the downregulation on miR-429 expression and the promotion on Occludin expression in the colon. In summary, tetrandrine can attenuate the intestinal epithelial barrier defects in colitis through promoting Occludin expression via the AhR/miR-429 pathway, and it might be used to treat colitis as a barrier protector.

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Quality Control of Diiodo(1,5-cyclooctadiene)platinum(II). Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about A new class of pnicogen-transition metal adducts: a stereo active lone pair at a 10-Sb-4 antimony center. Author is Stewart, Constantine A.; Arduengo, Anthony J. III.

L (I) reacted with (COD)PtI2 (COD = 1,5-cyclooctadiene) in toluene to give cis-PtL2I2 in which L coordinates through the Sb atom. L reacted with trans-[MePt(PPh3)2(Me2CO)]SbF6 in ether to give trans-MePt(PPh3)2L. trans-MePt(PPh3)2L.0.5(Me3Si)2O is monoclinic, space group P21/c, with a 1246.6(3), b 1752.9(4), c 2749.3(5) pm, β 92.64(2)°, Z = 4, d.(calculated) = 1.49 g cm3, R = 0.065, Rw = 0.090 for 4337 reflections. Changes in the bond angles and lengths in L upon coordination are attributed to steric congestion at the Pt atom due to 2 trans PPh3 ligands. In spite of steric congestion the L system maintains its 10-electron count and planar ligand backbone. NMR data for both complexes require the presence of a stereoactive bond pair at the Sb center.

If you want to learn more about this compound(Diiodo(1,5-cyclooctadiene)platinum(II))Quality Control of Diiodo(1,5-cyclooctadiene)platinum(II), you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(12266-72-7).

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Product Details of 4144-22-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Synthesis of Fused or Spiro Polyheterocyclic Compounds via the Dehydrogenative Annulation Reactions of 2-Arylindazoles with Maleimides.

A dehydrogenative annulation of 2-arylindazoles with maleimides for the switchable synthesis of indazolo[2,3-a]pyrrolo[3,4-c]quinolinones or spiroindolo[1,2-b]indazole-11,3′-pyrrolidinones is presented. Mechanistically, the formation of the title compounds involves a Rh(III)-catalyzed C-H metalation of 2-arylindazole, followed by maleimide insertion and intramol. cyclization. Interestingly, the selectivity to form the fused or spiro compounds could be switched by resorting to different additives. The notable features of this protocol include simple substrates and excellent atom economy and regioselectivity.

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Munakarmi, Suvesh; Shrestha, Juna; Shin, Hyun-Beak; Lee, Geum-Hwa; Jeong, Yeon-Jun published the article 《3,3′-diindolylmethane suppresses the growth of hepatocellular carcinoma by regulating its invasion, migration, and er stress-mediated mitochondrial apoptosis》. Keywords: DIM; EMT; ER stress; apoptosis; hepatocellular carcinoma; unfolded protein response.They researched the compound: 3,3′-Diindolylmethane( cas:1968-05-4 ).Category: chlorides-buliding-blocks. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1968-05-4) here.

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide with limited treatment options. Biomarker-based active phenolic flavonoids isolated from medicinal plants might shed some light on potential therapeutics for treating HCC. 3,3′-diindolylmethane (DIM) is a unique biol. active dimer of indole-3-carbinol (I3C), a phytochem. compound derived from Brassica species of cruciferous vegetables-such as broccoli, kale, cabbage, and cauliflower. It has anti-cancer effects on various cancers such as breast cancer, prostate cancer, endometrial cancer, and colon cancer. However, the mol. mechanism of DIM involved in reducing cancer risk and/or enhancing therapy remains unknown. The aim of the present study was to evaluate anti-cancer and therapeutic effects of DIM in human hepatoma cell lines Hep3B and HuhCell proliferation was measured with MTT and trypan blue colony formation assays. Migration, invasion, and apoptosis were measured with Transwell assays and flow cytometry analyses. Reactive oxygen species (ROS) intensity and the loss in mitochondrial membrane potential of Hep3B and Huh7 cells were determined using dihydroethidium (DHE) staining and tetramethylrhodamine Et ester dye. Results showed that DIM significantly suppressed HCC cell growth, proliferation, migration, and invasion in a concentration-dependent manner. Furthermore, DIM treatment activated caspasedependent apoptotic pathway and suppressed epithelial-mesenchymal transition (EMT) via ER stress and unfolded protein response (UPR). Taken together, our results suggest that DIM is a potential anticancer drug for HCC therapy by targeting ER-stress/UPR.

If you want to learn more about this compound(3,3′-Diindolylmethane)Category: chlorides-buliding-blocks, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1968-05-4).

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