Month: April 2022

Recommanded Product: 12266-72-7. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Heteropolytopic Arsanylarylthiolato Ligands: Cis-Trans Isomerism of Nickel(II), Palladium(II), and Platinum(II) Complexes of 1-AsPh2-2-SHC6H4.

Heteropolytopic arsinoarylthiolato ligands 1-AsPh2-2-SHC6H4 (AsSH), PhAs(2-SHC6H4)2 (AsS2H2), and As(2-SHC6H4)3 (AsS3H3) have been prepared by lithiation-electrophilic substitution procedures. The 2:1 reaction of AsSH with NiCl2·6H2O, Na2[PdCl4], and [PtI2(cod)] (cod = 1,5-cyclooctadiene) in the presence of NEt3 afforded the square-planar complexes trans-[Ni{(AsS)-κ2S,As}2] (1), cis-[Pd{(AsS)-κ2S,As}2] (2), trans-[Pd{(AsS)-κ2S,As}2] (3), and cis-[Pt{(AsS)-κ2S,As}2] (4). In the cases of nickel and platinum, only one isomer was isolated. With palladium, initially the cis isomer 2 is formed and undergoes slow isomerization to the trans isomer 3 in solution Small amounts of the trinuclear complex [{PtI(1-AsPh2-μ-2-S-C6H4-κ2S,As)}3] (5) are also formed besides the mononuclear platinum bis-chelate complex 4. D. functional theory calculations support a dissociative mechanism for the isomerization of the palladium(II) complexes.

《Heteropolytopic Arsanylarylthiolato Ligands: Cis-Trans Isomerism of Nickel(II), Palladium(II), and Platinum(II) Complexes of 1-AsPh2-2-SHC6H4》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Diiodo(1,5-cyclooctadiene)platinum(II))Recommanded Product: 12266-72-7.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3,3′-Diindolylmethane( cas:1968-05-4 ) is researched.Application In Synthesis of 3,3′-Diindolylmethane.Wang, Cuina; Zhou, Xinhui; Wang, Hao; Sun, Xiaomeng; Guo, Mingruo published the article 《Interactions between β-lactoglobulin and 3,3′-diindolylmethane in model system》 about this compound( cas:1968-05-4 ) in Molecules. Keywords: betalactoglobulin 3 diindolylmethane whey protein fabrication; 3,3′-diindolylmethane; molecular docking; spectroscopic analysis; β-lactoglobulin. Let’s learn more about this compound (cas:1968-05-4).

The compound 3,3′-diindolylmethane (DIM) has a broad spectrum of anticancer activities. However, low stability and bioavailability limit its application. Elucidating interactions between DIM and β-lactoglobulin (β-LG) may be useful for fabricating whey protein-based protecting systems. Interaction with DIM increased the diameter and absolute zeta potential value of β-LG. UV-absorption spectra suggested that there was a complex of DIM and β-LG. β-LG showed enhanced fluorescence intensity by complexing with DIM with a binding constant of 6.7 × 105 M-1 . Upon interaction with DIM, β-LG was decreased in secondary structure content of helix and turn while increased in β-sheet and unordered. FT-IR spectra and mol. docking results indicated the roles of hydrophobic interaction and hydrogen bond for the formation of DIM and β-LG nanocomplexes. Data suggested that β-LG may be a good vehicle for making a protein-based DIM protection and delivery system due to the tight binding of DIM to β-LG.

《Interactions between β-lactoglobulin and 3,3′-diindolylmethane in model system》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3,3′-Diindolylmethane)Application In Synthesis of 3,3′-Diindolylmethane.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 12266-72-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Comparison of the bonding in zero- and divalent platinum-olefin and -acetylene complexes from carbon-13 nuclear magnetic resonance parameters. XXII. Author is Chisholm, M. H.; Clark, H. C.; Manzer, L. E.; Stothers, J. B..

13C NMR parameters for simple olefin and acetylene complexes of Pt(0) and Pt(II) support the concept of a continuum of metal-olefin/acetylene bonding. The coupling constant 1J(195Pt-13C) for olefinic C depends on the trans influence of the trans ligand and thus reflects the Pt “”6s”” orbital contribution to the olefin-π to metal σ-bond.

《Comparison of the bonding in zero- and divalent platinum-olefin and -acetylene complexes from carbon-13 nuclear magnetic resonance parameters. XXII》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Diiodo(1,5-cyclooctadiene)platinum(II))Product Details of 12266-72-7.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 12266-72-7, is researched, Molecular C8H12I2Pt, about Organometallic palladium and platinum complexes with strongly donating alkyl coligands – Synthesis, structures, chemical and cytotoxic properties, the main research direction is organometallic palladium platinum complex preparation crystal mol structure antitumor; cyclooctadiene palladium platinum methyl neopentyl neosilyl trimethylsilylmethyl alkynyl complex; crystal mol structure cyclooctadiene palladium platinum benzyl neopentyl neosilyl; antitumor activity cyclooctadiene platinum methyl benzyl neosilyl alkynyl halide.Computed Properties of C8H12I2Pt.

The synthesis, spectroscopy, and structures of organometallic complexes [(COD)M(R)X] and [(COD)M(R)(R’)] (COD = 1,5-cyclooctadiene, M = Pd or Pt; R = Me, neopentyl (2,2-dimethylpropyl), neosilyl (trimethylsilylmethyl), or benzyl; X = Cl, Br, or I; R’ = 2-phenyl-ethynyl, p-fluoro-2-phenyl-ethynyl, p-methyl-2-phenyl-ethynyl or p-nitro-2-phenyl-ethynyl) has been explored. Selected samples of organo-platinum complexes show strikingly high cytotoxicity when tested against HT-29 and MCF-7 tumor cells.

《Organometallic palladium and platinum complexes with strongly donating alkyl coligands – Synthesis, structures, chemical and cytotoxic properties》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Diiodo(1,5-cyclooctadiene)platinum(II))Computed Properties of C8H12I2Pt.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C17H14N2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3′-diindolylmethane and chemotherapy drugs. Author is Nikulin, Sergey V.; Alekseev, Boris Ya.; Sergeeva, Nataliya S.; Karalkin, Pavel A.; Nezhurina, Elizaveta K.; Kirsanova, Valentina A.; Sviridova, Irina K.; Akhmedova, Suraja A.; Volchenko, Nadezhda N.; Bolotina, Larisa V.; Osipyants, Andrey I.; Hushpulian, Dmitry M.; Topchiy, Maxim A.; Asachenko, Andrey F.; Koval, Anastasia P.; Shcherbo, Dmitry S.; Kiselev, Vsevolod I.; Mikhaylenko, Dmitry S.; Schumacher, Udo; Poloznikov, Andrey A..

Epigenetic alterations represent promising therapeutic targets in cancer treatment. Recently it was revealed that small mols. have the potential to act as microRNA silencers. Capacity to bind the discrete stem-looped structure of pre-miR-21 and prevent its maturation opens opportunities to utilize such compounds for the prevention of initiation, progression, and chemoresistance of cancer. Mol. simulations performed earlier identified 3,3′-diindolylmethane (DIM) as a potent microRNA-21 antagonist. However, data on DIM and microRNA-21 interplay is controversial, which may be caused by the limitations of the cell lines.

Different reactions of this compound(3,3′-Diindolylmethane)Electric Literature of C17H14N2 require different conditions, so the reaction conditions are very important.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 1968-05-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Anti-cancer effects of 3, 3′-diindolylmethane on human hepatocellular carcinoma cells is enhanced by calcium ionophore: the role of cytosolic Ca2+ and p38 MAPK. Author is Jiang, Yuanyue; Fang, Yanfei; Ye, Yang; Xu, Xinming; Wang, Bingfang; Gu, Jie; Aschner, Michael; Chen, Jian; Lu, Rongzhu.

Purpose: 3,3′-Diindolylmethane (DIM), derived from indole-3-carbinol (I3C) in the Brassica species of cruciferous vegetables, has anticancer effects, but its exact underlying mechanism of action is unknown. We explored the roles of cytosolic free calcium ([Ca2+]i) and p38 MAPK in the anti-cancer effects of DIM in human hepatocellular carcinoma cells. Methods: Cell proliferation was measured with a Cell Counting Kit-8 (CCK-8) and the clonogenic formation assay. Cell apoptosis was examined by flow cytometric anal. and Hoechst dye staining. Cleaved-caspase3, cleaved-PARP, Bax, total, and phosphorylated p38 MAPK were assayed by western blotting. [Ca2+]i was measured with Fluo-3/AM by fluorescence microscopy. A23187, a calcium ionophore, was used to increase [Ca2+]i levels. Results: DIM inhibited cell proliferation in both SMMC-7721 and HepG2 cells in a concentration- and time-dependent manner. DIM also enhanced phosphorylation of p38 MAPK (p-p38), which was attenuated by SB203580. The proliferation inhibition and apoptosis induction by DIM were also blunted. In addition, DIM increased [Ca2+]i in HCC cells, and this effect was inhibited by the calcium chelator, BAPTA-AM, resulting in reduced p-p38 MAPK activation and apoptosis in DIM-treated cells, though the proliferation inhibition by DIM was unchanged. However, the DIM-induced cell proliferation inhibition and apoptosis were significantly enhanced by A23187, a selective calcium ionophore, which was attributed to exaggerated p-p38 MAPK. Conclusions: The calcium ionophore enhanced DIM-induced anti-cancer effects in hepatocellular carcinoma cells, secondary to [Ca2+]i-dependent activation of p38 MAPK. Treatment with a combination of DIM and calcium ionophore may offer a new approach to enhance the chemotherapeutic efficacy in liver cancer.

Different reactions of this compound(3,3′-Diindolylmethane)SDS of cas: 1968-05-4 require different conditions, so the reaction conditions are very important.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C8H11NO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Quantification of reduced and oxidized thiols in mouse serum by column-switching hydrophilic interaction chromatography coupled with mass spectrometry. Author is Iwasaki, Yusuke; Nakano, Yuki; Mochizuki, Keisuke; Ogawa, Toyoko; Oda, Momoko; Ito, Rie; Saito, Koichi; Nakazawa, Hiroyuki.

An automated online solid-phase extraction method for the determination of the reduced and oxidized forms of thiols in mouse serum was developed and validated. Anal. was performed with column-switching hydrophilic interaction chromatog. coupled with mass spectrometry (CS-HILIC-MS). The proposed CS-HILIC-MS method enabled the simultaneous determination of reduced and oxidize d thiols in mouse serum samples. In addition, interference from endogenous compounds was removed by means of the column-switching technique. The authors also compared the effects of derivatization before and after preparing serum from blood samples and found that it was necessary to perform the derivatization immediately before preparing serum from blood samples. We investigated the role of thiol compounds in lipopolysaccharide (LPS)-induced acute inflammation in vivo. Serum glutathione disulfide and cystine levels were significantly decreased at 4 h after LPS treatment. Our method is expected to be useful for the assessment of the roles of reduced and oxidized glutathione in the oxidative state.

Different reactions of this compound(1-(tert-Butyl)-1H-pyrrole-2,5-dione)Formula: C8H11NO2 require different conditions, so the reaction conditions are very important.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Diiodo(1,5-cyclooctadiene)platinum(II)(SMILESS: I[Pt]I.C1=CCC/C=CCC/1,cas:12266-72-7) is researched.Recommanded Product: 3,3′-Diindolylmethane. The article 《Classics Meet Classics: Theoretical and Experimental Studies of Halogen Bonding in Adducts of Platinum(II) 1,5-Cyclooctadiene Halide Complexes with Diiodine, Iodoform, and 1,4-Diiodotetrafluorobenzene》 in relation to this compound, is published in Crystal Growth & Design. Let’s take a look at the latest research on this compound (cas:12266-72-7).

Complexes of PtX2COD (X = Cl, Br, I; COD = 1,5-cyclooctadiene) were cocrystd. with classical halogen-bond donors (CHI3, I2, and 1,4-diiodotetrafluorobenzene (FIB)), resulting in noncovalently bound supramol. aggregates of various lengths-from heterotrimers to polymers. The influence of halides in the complexes on the geometry and strength of the halogen bond (XB) was studied both exptl. by single-crystal XRD and theor. by quantum chem. methods such as noncovalent interaction plots (NCI-plot), electrostatic potential (ESP) surface anal., and a combination of electron localization function (ELF) and quantum theory of atoms in mols. (QTAIM) analyses. It was shown that strength of XB interactions in the adducts increases in the order CHI3 > FIB > I2. Although halogen bonding was found to be the main preorganizing force in the structures, in the case of FIB adducts a rare Pt···I interaction was involved in addnl. stabilization of the structure. Hence, fine-tuning of halogen bonding can influence the length of the polymer, as well as the strength and directionality of interactions in the adduct. Since Hassel’s already classical work on charge-transfer interactions, halogen bonding has attracted a great deal of attention as a potentially useful instrument to organize mols. Due to the tunability, relative strength, and directionality, halogen bonding has been used as a self-assembly tool in crystal engineering. In this study classics meet classics: classical halogen bond donors XBD (such as mol. iodine, iodoform, and FIB) and classical synthons PtX2COD were used to create metallopolymeric adducts. In the obtained systems the XBD influenced the geometry (1D or 2D) and the length (heterotrimer or polymer) of the adduct. To understand differences among the obtained systems, they were further studied with computational methods, and addnl. stabilizing weak interactions were discovered. Caution: COD is hazardous to health and should be handled with care.

Different reactions of this compound(Diiodo(1,5-cyclooctadiene)platinum(II))COA of Formula: C8H12I2Pt require different conditions, so the reaction conditions are very important.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 3,3′-Diindolylmethane. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Epigenetic control of pancreatic carcinogenesis and its regulation by natural products. Author is Zubair, Haseeb; Azim, Shafquat; Khan, Mohammad Aslam; Patel, Girijesh Kumar; Ahmad, Aamir; Pai, Sachin; Singh, Seema; Singh, Ajay P..

A review. Pathogenesis of pancreatic cancer (PC) involves both genetic and epigenetic alterations. While genetic aberrations have been the focus of a majority of studies, recent research has highlighted the benefit of therapeutically targeting epigenetic changes because of their reversible nature. Differential promoter DNA methylation of tumor-suppressor genes/oncogenes and chromatin remodeling through histone methylation/acetylation represent some of the more well-characterized epigenetic changes that have been associated with PC onset and progression. A number of key enzymes, such as DNA methyltransferases, histone deacetylases, and enhancer of zeste homolog 2 that play important roles in epigenetic modifications in PC, are targets of anticancer agents obtained from natural products. Prominent among these natural products are 3-3′-diindolylmethane, epigallocatechin-3-gallate, and resveratrol as well as derivatives of curcumin. This chapter provides a comprehensive overview of epigenetic events that are relevant to PC pathogenesis, along with promising emerging data on the regulation of these epigenetic events by natural products.

Different reactions of this compound(3,3′-Diindolylmethane)Recommanded Product: 3,3′-Diindolylmethane require different conditions, so the reaction conditions are very important.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Diiodo(1,5-cyclooctadiene)platinum(II)(SMILESS: I[Pt]I.C1=CCC/C=CCC/1,cas:12266-72-7) is researched.SDS of cas: 86404-63-9. The article 《Solid-state 13C NMR and quantum chemical investigation of metal diene complexes》 in relation to this compound, is published in Magnetic Resonance in Chemistry. Let’s take a look at the latest research on this compound (cas:12266-72-7).

This paper presents novel measurements and calculations of the olefinic 13C chem. shift tensor principal values in several metal diene complexes. The exptl. values and the calculations show shifts as large as 70 ppm with respect to the values in the parent olefinic compounds These shifts are highly anisotropic, with the largest ones observed in the less shielded principal components and the smallest ones in the most shielded principal components of the tensor. The orientations of the principal components of the tensors remain, within 10°, at their directions in ethylene and other olefinic compounds The calculations, performed using the GIAO method and the LanDZ pseudopotential basis set, show good agreement with the experiments, and were used to establish definite evidence for the existence of a Cl-bridge structure in the bicyclo[2.2.1]hepta-2,5-diene (BCHD)dichlororuthenium(II) polymer.

Different reactions of this compound(Diiodo(1,5-cyclooctadiene)platinum(II))Computed Properties of C8H12I2Pt require different conditions, so the reaction conditions are very important.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics