Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1968-05-4, is researched, Molecular C17H14N2, about 3,3′.Diindolylmethane mitigates lipopolysaccharide.induced acute kidney injury in mice by inhibiting NOX.mediated oxidative stress and the apoptosis of renal tubular epithelial cells, the main research direction is acute kidney injury renal tubular epithelial cell apoptosis NOX2; NOX4 DIM oxidative stress.Product Details of 1968-05-4.
3,3′-D iindolylmethane (DIM) is a naturally derived indole compound found in the Brassica family of vegetables. DIM has several beneficial effects, including anti-cancer, anti-inflammatory and anti-angiogenic functions. However, the effects of DIM on acute kidney injury (AKI) stimulated by lipopolysaccharide (LPS) are poorly studied. In this present study, male BALB/c mouse models of AKI were established using i.p. injections of 10 mg/kg LPS. DIM (40 mg/kg) was administered i.p. 24 and 2 h before LPS exposure. The results indicated that DIM significantly mitigated histopathol. changes in the kidneys and improved the levels of blood urea nitrogen and serum creatinine. DIM also suppressed the LPS-induced production of reactive oxygen species and cell apoptosis. Furthermore, DIM treatment significantly decreased the expression of NADPH oxidase 2 (NOX2) and NOX4 in LPS-treated mice. Therefore, DIM may exert its renoprotective actions by inhibiting NOX-mediated oxidative stress and the apoptosis of renal tubular epithelial cells.
There is still a lot of research devoted to this compound(SMILES：C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4)Product Details of 1968-05-4, and with the development of science, more effects of this compound(1968-05-4) can be discovered.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics