In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Nanoformulated bioactive compounds derived from different natural products combat pancreatic cancer cell proliferation, published in 2020, which mentions a compound: 1968-05-4, Name is 3,3′-Diindolylmethane, Molecular C17H14N2, HPLC of Formula: 1968-05-4.
This study was designed to determine the potential effect of nanoencapsulated bioactive compounds from different natural sources on human pancreatic cancer. Pancreatic cancer carries the highest fatality rate among all human cancers because of its high metastatic potential and late presentation at the time of diagnosis. Hence there is a need for improved methods to prevent and treat it. Natural products, such as 3, 3′-diindolylmethane (DIM) and ellagic acid (EA) demonstrated anticancer efficacy against various cancer types. However, DIM is insoluble Hence, using nanotechnol. to encapsulate these compounds in combination with EA might improve their phys. and chem. properties and their delivery to the cancer cells. Human pancreatic cancer cells, namely SUIT2-luciferase transfected, were used to examine the effects of DIM or EA and their nanoformulation in poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) [PLGA-PEG] nanoparticles (NPs) on SUIT2-luciferase cell viability/proliferation over 24 h. Addnl., effects on tumor weight and angiogenesis were determined using the chick chorioallantoic membrane (CAM) tumor implant model. Both DIM and EA PLGA-PEG NPs resulted in rapid suppression of pancreatic cancer cell viability/proliferation within 24 h (P < 0.01), while the non-encapsulated DIM and EA did not show any significant effect on SUIT2 cancer cell viability or cell proliferation (MTT assay). In the CAM pancreatic cancer cell (SUIT2) implant model, results showed a greater suppression of tumor weight (P < 0.01), tumor cell viability, and tumor angiogenesis (P < 0.01) for DIM NPs and EA NPs and their combinations vs. DIM or EA alone. Nanoformulation of DIM and EA resulted in a more effective suppression of pancreatic cancer cell viability, pancreatic tumor weight, implanted cancer cell viability, and tumor angiogenesis as compared with these bioactive compounds alone. From this literature《Nanoformulated bioactive compounds derived from different natural products combat pancreatic cancer cell proliferation》,we know some information about this compound(1968-05-4)HPLC of Formula: 1968-05-4, but this is not all information, there are many literatures related to this compound(1968-05-4).
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics