Category: chlorides-buliding-blocks. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Pharmacophore-inspired discovery of FLT3 inhibitor from kimchi.
Globally consumed kimchi is manufactured through fermenting cruciferous vegetables containing indole glucosinolates (IG). But few reports describe the IG metabolism during the fermentation Here, we show that indole-3-carbinol (I3C), a breakdown product of IG, is transformed during the kimchi fermentation into 3,3-diindolylmethane (DIM) and 2-(indol-3-ylmethyl)-3,3-diindolylmethane (LTr1). LTr1 was found to kill the acute myeloid leukemia (AML) cells with FMS-like tyrosine kinase 3 (FLT3) receptor mutations, by inhibiting the FLT3 phosphorylation and the expression of downstream proteins (STAT5, ERK, and AKT). In the immune-depleted mice xenografted with human MV4-11 cells, LTr1 was demonstrated to reduce the tumor growth and synergize with sorafenib, an anti-AML agent in clinic. The work updates the chem. and biol. knowledge about kimchi, and in particular establishes LTr1 as an FLT3 inhibitor that is effective and synergistic with sorafenib in treating AML.
From this literature《Pharmacophore-inspired discovery of FLT3 inhibitor from kimchi》,we know some information about this compound(1968-05-4)Category: chlorides-buliding-blocks, but this is not all information, there are many literatures related to this compound(1968-05-4).
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics