Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 12266-72-7, is researched, SMILESS is I[Pt]I.C1=CCC/C=CCC/1, Molecular C8H12I2PtJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called (2,2′:6′,2”-Terpyridine)platinum(II) Complexes Are Irreversible Inhibitors of Trypanosoma cruzi Trypanothione Reductase But Not of Human Glutathione Reductase, Author is Bonse, Susanne; Richards, Jonathan M.; Ross, Steven A.; Lowe, Gordon; Krauth-Siegel, R. Luise, the main research direction is terpyridine platinum complex Trypanosoma trypanothione reductase inhibitor.Related Products of 12266-72-7.
(2,2′:6′,2”-Terpyridine)platinum(II) complexes possess pronounced cytostatic activities against trypanosomes and leishmania. As shown here, the complexes are irreversible inhibitors of trypanothione reductase (TR) from Trypanosoma cruzi, the causative agent of Chagas’ disease. The most effective derivatives are the (4′-chloro-2,2′:6′,2”-terpyridine)platinum(II) ammine and the (4-picoline)(4′-p-bromophenyl-2,2′:6′,2”-terpyridine)platinum(II) complexes which in the presence of NADPH inhibit TR with second-order rate constants of about 1.3×104 M-1 s-1. The modified enzyme species possess increased oxidase activities. The inhibition is not reversed upon dialysis or treatment with low-mol.-mass thiols. Kinetic and spectroscopic data suggest that Cys52 in the active site has been specifically altered. Inhibition of this key enzyme of parasite thiol metabolism probably contributes to the antitrypanosomal activity of the compounds In contrast to the parasite enzyme, most (terpyridine)platinum complexes interact only reversibly with human glutathione reductase and an initial inhibition is completely abolished during the course of the assay.
There is still a lot of research devoted to this compound(SMILES：I[Pt]I.C1=CCC/C=CCC/1)Related Products of 12266-72-7, and with the development of science, more effects of this compound(12266-72-7) can be discovered.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics