Recommanded Product: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Empowering alcohols as carbonyl surrogates for Grignard-type reactions. Author is Li, Chen-Chen; Wang, Haining; Sim, Malcolm M.; Qiu, Zihang; Chen, Zhang-Pei; Khaliullin, Rustam Z.; Li, Chao-Jun.
Herein, Grignard-type reaction with alcs. as carbonyl surrogates by using a ruthenium(II) PNP-pincer complex as catalyst was reported. This transformation proceeds via a carbonyl intermediate generated in situ from the dehydrogenation of alcs., which was followed by a Grignard-type reaction with a hydrazone carbanion to form a C-C bond. The reaction conditions were mild and can tolerate a broad range of substrates. Moreover, no oxidant was involved during the entire transformation, with only H2 and N2 being generated as byproducts. This reaction opened up a new avenue for Grignard-type reactions by enabling the use of naturally abundant alcs. as starting materials without the need for pre-synthesizing carbonyls.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics