Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Gut Microbes called Cruciferous vegetables (Brassica oleracea) confer cytoprotective effects in Drosophila intestines, Author is Lyles, James T.; Luo, Liping; Liu, Ken; Jones, Dean P.; Jones, Rheinallt M.; Quave, Cassandra L., which mentions a compound: 1968-05-4, SMILESS is C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4, Molecular C17H14N2, COA of Formula: C17H14N2.
Varieties and cultivars of the cruciferous vegetable Brassica oleracea are widely presumed to elicit pos. influences on mammalian health and disease, particularly related to their indole and sulforaphane content. However, there is a considerable gap in knowledge regarding the mechanisms whereby these plant-derived mols. elicit their beneficial effects on the host. In this study, we examined the chem. variation between B. oleracea varieties and evaluated their capacity to both activate Nrf2 in the Drosophila intestine and elicit cytoprotection. Ten types of edible B. oleracea were purchased and B. macrocarpa was wild collected. Fresh material was dried, extracted by double maceration and green kale was also subjected to anaerobic fermentation before processing. Untargeted metabolomics was used to perform Principal Component Anal. Targeted mass spectral anal. determined the presence of six indole species and quantified indole. Extracts were tested for their capacity to activate Nrf2 in the Drosophila intestine in third instar Drosophila larvae. Cytoprotective effects were evaluated using a paraquat-induced oxidative stress gut injury model. A “”Smurf”” assay was used to determine protective capacity against a chem. induced leaky gut. Extracts of Brussels sprouts and broccoli activated Nrf2 and protected against paraquat-induced damage and leaky gut. Lacto-fermented kale showed a cytoprotective effect, increasing survival by 20% over the non-fermented extract, but did not protect against leaky gut. The protective effects observed do not directly correlate with indole content, suggesting involvement of multiple compounds and a synergistic mechanism.
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Chloride – Wikipedia,
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