Fischer-Fodor, Eva; Moldovan, Natalia; Virag, Piroska; Soritau, Olga; Brie, Ioana; Lonnecke, Peter; Hey-Hawkins, Evamarie; Silaghi-Dumitrescu, Luminita published the article 《The CellScan technology for in vitro studies on novel platinum complexes with organoarsenic ligands》. Keywords: CellScan laser spectroscopy platinum complex organoarsenic ligand antitumor.They researched the compound: Diiodo(1,5-cyclooctadiene)platinum(II)( cas:12266-72-7 ).Formula: C8H12I2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:12266-72-7) here.
The present paper examines one of the multiple uses of the CellScan technique, its utilization in the biol. evaluation of novel compounds, in order to improve the methods concerning the prediction of their anti-proliferative effects and application as anti-cancer drugs. The CellScan is a laser scanning static cytometer, enabling repetitive spectroscopic measurements in intact living cells. The detection of cell viability and apoptosis is possible, based on the transformations that occur in the cytoplasm matrix of tumor cells influenced by cytotoxic compounds The measurement of fluorescence changes, due to this phenomenon, is possible with the CellScan system. The potential of this technol. to detect the in vitro effects of the inhibitory mols. on tumor cells was demonstrated, making this method a valuable tool for chemosensitivity tests. We synthesized and fully characterized three novel platinum complexes of tertiary arsine ligands: trans-[PtI2(2-iPrOC6H4AsPh2)2] (1), trans-[PtCl2(2-MeOC6H4AsPh2)2] (2) and cis-[PtCl2(2-HOC6H4AsPh2)2] (3). The three compounds are biol. active against tumor cells and their cytotoxicity is comparable with standard drugs. Measurements using the CellScan technol. correlate well with the results provided by other bioassay methods.
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Reference:
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