Quality Control of tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate, is researched, Molecular C19H28BNO4, CAS is 837392-67-3, about Identification of 5-(2,3-Dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as a new class of receptor-interacting protein kinase 1 (RIPK1) inhibitors, which showed potent activity in a tumor metastasis model. Author is Li, Yueshan; Xiong, Yu; Zhang, Guo; Zhang, Liting; Yang, Wei; Yang, Jiao; Huang, Luyi; Qiao, Zeen; Miao, Zhuang; Lin, Guifeng; Sun, Qiu; Niu, Ting; Chen, Lijuan; Niu, Dawen; Li, Linli; Yang, Shengyong.
We herein report the structural optimization and structure-activity relationship studies of 5-(2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as a new class of receptor-interacting protein kinase 1 (RIPK1) inhibitors. Among all obtained RIPK1 inhibitors, I is the most active one. This compound potently inhibited RIPK1 with a binding affinity (KD) of 0.004μM and an enzymic IC50 value of 0.011μM and also showed good kinase selectivity. It could efficiently protect cells from necroptosis and attenuate the necrotic cell death of vascular endothelial cells induced by tumor cells both in vitro and in vivo. Importantly, I exhibited excellent antimetastasis activity in the exptl. B16 melanoma lung metastasis model. It also displayed favorable pharmacokinetic properties. Collectively, I could be a promising agent for preventing tumor metastasis.
I hope my short article helps more people learn about this compound(tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate)Quality Control of tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate. Apart from the compound(837392-67-3), you can read my other articles to know other related compounds.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics