Let`s talk about compounds: 37481-18-8

Here is just a brief introduction to this compound(37481-18-8)Application In Synthesis of 2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine, more information about the compound(2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine) is in the article, you can click the link below.

Application In Synthesis of 2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine, is researched, Molecular C11H16N2, CAS is 37481-18-8, about Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. Author is Neelakantan, Harshini; Wang, Hua-Yu; Vance, Virginia; Hommel, Jonathan D.; McHardy, Stanton F.; Watowich, Stanley J..

Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have identified small mol. inhibitors of NNMT with >1000-fold range of activity and developed comprehensive structure-activity relationships (SARs) for NNMT inhibitors. Screening of N-methylated quinolinium, isoquinolinium, pyrididium, and benzimidazolium/benzothiazolium analogs resulted in the identification of quinoliniums as a promising scaffold with very low micromolar (IC50 ∼ 1 μM) NNMT inhibition. Computer-based docking of inhibitors to the NNMT substrate (nicotinamide)-binding site produced a robust correlation between ligand-enzyme interaction docking scores and exptl. calculated IC50 values. Predicted binding orientation of the quinolinium analogs revealed selective binding to the NNMT substrate-binding site residues and essential chem. features driving protein-ligand intermol. interactions and NNMT inhibition. The development of this new series of small mol. NNMT inhibitors direct the future design of lead drug-like inhibitors to treat several metabolic and chronic disease conditions characterized by abnormal NNMT activity.

Here is just a brief introduction to this compound(37481-18-8)Application In Synthesis of 2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine, more information about the compound(2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine) is in the article, you can click the link below.

Reference:
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