Formula: C6H11NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS. Author is Romano, Giulia; Holodkov, Nikola; Klima, Raffaella; Feiguin, Fabian.
Alterations in the function of the RNA-binding protein TDP-43 are largely associated with the pathogenesis of amyotrophic lateral sclerosis (ALS), a devastating disease of the human motor system that leads to motoneurons degeneration and reduced life expectancy by mol. mechanisms not well known. In our previous work, we found that the expression levels of the glutamic acid decarboxylase enzyme (GAD1), responsible for converting glutamate to γ-aminobutyric acid (GABA), were downregulated in TBPH-null fies and motoneurons derived from ALS patients carrying mutations in TDP-43, suggesting that defects in the regulation of GAD1 may lead to neurodegeneration by afecting neurotransmitter balance. In this study, we observed that TBPH was required for the regulation of GAD1 pre-mRNA splicing and the levels of GABA in the Drosophila central nervous system (CNS). Interestingly, we discovered that pharmacol. treatments aimed to potentiate GABA neurotransmission were able to revert locomotion defciencies in TBPH-minus fies, revealing novel mechanisms and therapeutic strategies in ALS.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics