Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 37481-18-8, is researched, Molecular C11H16N2, about 2-Methoxy-6-chloro-9-(N-substituted-amino)-acridines. II. Compounds Derived from Cyclic Secondary Amines, the main research direction is ACRIDINE DYES/chemistry.Recommanded Product: 37481-18-8.
The γ-substituted propionitriles were prepared by adding the secondary amines to an excess of CH2:CHCN: 1-pyrrolidyl, b28 110-12°, 81% (flavianate, m. 140-5°); 1-piperidyl, b27 125-30°, 74%; 2-methyl-1-piperidyl, b30 137-40°, 99%; 3-isomer, b28 126-8°, 97%; 4-isomer, b27-8 127-30°, 87%; 2,3-dimethyl-1-piperidyl, b35 140-2°, 99%; 2,4-isomer, b29 130-3°, 68%; 2, 6-isomer, b26-8 121-5°, 82%. The nitriles were reduced by Raney Ni in ether-NH3 or with Na in EtOH; 3-substituted propylamines: 1-pyrryl, b30 117-20°, 86% (picrate, m. 135-7°); 1-pyrrolidyl, b26 85-7°, 71% (picrate, m. 219-31° (decomposition)); 1-piperidyl, b31 110-15°, 77% (picrate, m. 195-204° (decomposition)); 2-methyl-1-piperidyl, b755 163-70°, 45% (picrate, m. 212-15°); 3-isomer, b27 110-12°, 85% (picrate, m. 185-7°); 4-isomer, b18 90-2°, 74% (picrate, m. 212-14°; phenylthiourea, m. 140-1°); 2, 3-dimethyl-1-piperidyl, b22 114-15°, 62% (picrate, m. 208-10°); 2,4-isomer, b34 120-2°, 52% (picrate, m. 203-5°); 2,6-isomer, b31-2 122-30°, 38% (picrate, m. 206-8°). 2-Methylpiperidine-HCl (67.7 g.), 290 g. Me2CO, 160 mL. H2O, and 90 mL. 37% HCHO, refluxed overnight, give 47.5 g. 4-(2-methyl-1-piperidyl)-2-butanone, b17-18 87-91°; the oxime b2 116-20°; reduction with Na in EtOH gives 4-(2-methyl-1-piperidyl)-2-butylamine, b26 113-16°. N-Substituted 2-methoxy-6-chloro-9-aminoacridine di-HCl salts: 3-(1-pyrryl)propyl, m. 210-13°; 3-(1-pyrrolidyl)propyl, m. 228-30°; 3-(1-piperidyl)propyl, m. 245-7°; 3-(2-methyl-1-piperidyl)propyl, m. 255-7°; 3-Me isomer, m. 241-2° (decomposition); 4-Me isomer, m. 256-7° (decomposition); 3-(2,3-dimethyl-1-piperidyl)propyl, m. 238-40°; 2, 4-di-Me isomer, m. 234-6°; 2,6-di-Me isomer, m. 239-41°; 4-(2-methyl-1-pperidyl)-3-Bu, m. 247-8°. 1,2,3,4-Tetrahydroquinoline (20 g.), 28.1 g. C6H4(CO)2NC2H4Br, 2 g. KI, and 25 mL. Methyl Cellosolve, heated on a steam bath overnight, give N-[2-(1,2,3,4-tetrahydro-1-quinolyl)ethyl]phthalimide, m. 131-3°; the resulting ethylamine gives 2-methoxy-6-chloro-9-[2-(1,2,3,4-tetrahydro-1-quinolyl)ethylamino]-acridine-2HCl, m. 156-8°. Histamine gives a small yield of 2-methoxy-6-chloro-9-[2-(4(or 5)-imidazolyl)ethylamino]acridine-2HCl, m. 250-5°.
In addition to the literature in the link below, there is a lot of literature about this compound(2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine)Recommanded Product: 37481-18-8, illustrating the importance and wide applicability of this compound(37481-18-8).
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics