The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about Synthesis, spectral characterization, and biological studies of 3,5-disubstituted-1,3,4-oxadiazole-2(3H)-thione derivatives, the main research direction is dichlorophenyl oxadiazolethione piperidine preparation antitumor antibacterial antifungal antiyeast activity; antibacterial activity; cytotoxicity; piperidine; 1,3,4-Oxadiazole.Product Details of 498-95-3.
The reaction of 3,4-dichlorophenyl-1,3,4-oxadiazole-2(3H)-thione with piperidine derivatives I (R = H, ethoxycarbonyl; R1 = H, carboxy, ethoxycarbonyl; R2 = H, OH, CN, acetyl; R3 = ethoxycarbonyl, Ph, morpholin-4-yl, etc.) via Mannich reaction was used to generate eleven novel compounds in moderate to good yields. Antimicrobial activity and cytotoxicity studies were done by disk diffusion and NCI-60 sulfordamine B assay methods. The antimicrobial test results revealed that synthesized compounds I have better activity against gram-pos. species than gram-neg. ones. A total anal. of the antibacterial, antifungal, and antiyeast activity revealed that newly synthesized compounds I were really active against Bacillus cereus, Bacillus ehimensis, and Bacillus thuringiensis species. For cytotoxicity, among three different cancer cell lines (HCT116, MCF7, HUH7) compounds I [R = R1 = H, R2 = acetyl, R3 = Ph (II); R = R1 = H, R2 = CN, R3 = Ph (III); R = R1 = R2 = H, R3 = Bn (IV); R = R1 = R2 = H, R3 = morpholin-4-yl (V); R = R1 = R2 = H, R3 = carboxy (VI); R = R1 = R2 = H, R3 = ethoxycarbonyl (VII); R = H, R1 = ethoxycarbonyl, R2 = R3 = H (VIII); and R = ethoxycarbonyl, R1 = R2 = R3 = H] were seemed especially effective on HUH7 cancer cell line via moderate to good activity. More significantly, against liver carcinoma cell line (HUH7) most of the compounds of the series (II, III, IV, V, VI, VII, and VIII) have better IC50 values (IC50 = 18.78μM) than 5-Fluorouracil (5-FU) and also compound III possessed 10.1μM value, which represents good druggable cytotoxic activity. Further, the mols. I were also screened for in silico chemoinformatic and toxicity data to gather the predicted bioavailability and safety measurements.
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Reference:
Chloride – Wikipedia,
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