Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 837392-67-3, is researched, SMILESS is O=C(N1CCC2=C1C=CC(B3OC(C)(C)C(C)(C)O3)=C2)OC(C)(C)C, Molecular C19H28BNO4Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor γ (ERRγ) Inverse Agonists, Author is Kim, Jina; Woo, Seo Yeon; Im, Chun Young; Yoo, Eun Kyung; Lee, Seungmi; Kim, Hyo-Ji; Hwang, Hee-Jong; Cho, Joong-heui; Lee, Won Seok; Yoon, Heeseok; Kim, Shinae; Kwon, Oh-bin; Hwang, Hayoung; Kim, Kyung-Hee; Jeon, Jae-Han; Singh, Thoudam Debraj; Kim, Sang Wook; Hwang, Sung Yeoun; Choi, Hueng-Sik; Lee, In-Kyu; Kim, Seong Heon; Jeon, Yong Hyun; Chin, Jungwook; Cho, Sung Jin, the main research direction is hydroxytamoxifen analog synthesis SAR cytotoxicity pharmacokinetics estrogen related receptor.Name: tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate.
We evaluated the in vitro pharmacol. as well as the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of chem. entities that have not only shown to be highly selective agonists for ERRγ, but also exhibited enhanced pharmacokinetic profile than 3 (GSK5182). 6G and 10b had comparable potency to 3 and were far more selective for ERRγ over the ERRα, -β, and ERα. The in vivo pharmacokinetic profiles of 6g and 10b were further evaluated as they possessed superior in vitro ADMET profiles compared to the other compounds Addnl., we observed a significant increase of fully-glycosylated NIS protein, key protein for radioiodine therapy in anaplastic thyroid cancer (ATC), in 6g- or 10b-treated CAL62 cells, which indicated that these compounds could be promising enhancers for restoring NIS protein function in ATC cells. Thus, 6g and 10b possess advantageous drug-like properties and can be used to potentially treat various ERRγ-related disorders.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics