SDS of cas: 498-95-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about Synthesis and Biological Evaluation of Nipecotic Acid and Guvacine Derived 1,3-Disubstituted Allenes as Inhibitors of Murine GABA Transporter mGAT1. Author is Schaarschmidt, Maren; Hoefner, Georg; Wanner, Klaus T..
A new class of nipecotic acid I [R = Ph, 2-fluorophenyl, 4-biphenyl, etc.] and guvacine derivatives II [R1 = 2,4-difluoropheny, 2,4-dichlorophenyl, 2-phenylphenyl] were synthesized and characterized for their inhibitory potency at mGAT1-4 and binding affinity for mGAT1. Compounds I and II were defined by a four-carbon-atom allenyl spacer connecting the nitrogen atom of the nipecotic acid or guvacine head with an aromatic residue. Among the compounds investigated, the mixture of nipecotic acid derivatives I [R = terphenyl] possessing an o-terphenyl residue, was identified as highly selective and the most potent mGAT1 inhibitor in this study. For the (R)-nipecotic acid derived from of compound I [R = terphenyl], the inhibitory potency in [3H]GABA uptake assays was determined as pIC50=6.78±0.08, and the binding affinity in MS Binding Assays as pKi=7.10±0.12. The synthesis of the designed compounds I and II was carried out by a two-step procedure, generating the allene moiety via allenylation of terminal alkynes which allowed broad variation of the terminal Ph and biphenyl subunit.
Compounds in my other articles are similar to this one(Piperidine-3-carboxylic acid)SDS of cas: 498-95-3, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics