So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Dhanawat, Meenakshi; Gupta, Sumeet; Mehta, Dinesh Kumar; Das, Rina researched the compound: Piperidine-3-carboxylic acid( cas:498-95-3 ).Recommanded Product: 498-95-3.They published the article 《Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug》 about this compound( cas:498-95-3 ) in Drug Research (Stuttgart, Germany). Keywords: pentylenetetrazole serine nipecotic acid blood brain barrier. We’ll tell you more about this compound (cas:498-95-3).
Nipecotic acid is considered to be one of the most potent inhibitors of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Due to its hydrophilic nature, nipecotic acid does not readily cross the blood-brain barrier (BBB). Large neutral amino acids (LAT1)-knotted nipecotic acid prodrug was designed and synthesized with the aim to enhance the BBB permeation by the use of carrier-mediated transport. The synthesized prodrug was tested in animal models of Pentylenetetrazole (PTZ)-induced convulsions in mice. Further pain studies were carried out followed by neurotoxicity estimation by writhing and rota-rod test resp. HPLC data suggests that the synthesized prodrug has improved penetration through BBB. Nipecotic acid-L-serine ester prodrug with considerable anti-epileptic activity, and the ability to permeate the BBB has been successfully synthesized.
Although many compounds look similar to this compound(498-95-3)Recommanded Product: 498-95-3, numerous studies have shown that this compound(SMILES:O=C(C1CNCCC1)O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics