The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Piperidine-3-carboxylic acid(SMILESS: O=C(C1CNCCC1)O,cas:498-95-3) is researched.Formula: C8H12I2Pt. The article 《Midazolam Exposure Impedes Oligodendrocyte Development via the Translocator Protein and Impairs Myelination in Larval Zebrafish》 in relation to this compound, is published in Molecular Neurobiology. Let’s take a look at the latest research on this compound (cas:498-95-3).
Anesthetics are commonly used in various medical procedures. Accumulating evidence suggests that early-life anesthetics exposure in infants and children affects brain development, causing psychiatric and neurol. disorders. However, the underlying mechanisms are poorly understood. Using zebrafish larvae as a model, we found that the proliferation and migration of oligodendrocyte progenitor cells (OPCs) were severely impaired by the exposure of midazolam (MDZ), an anesthetic widely used in pediatric surgery and intensive care medicine, leading to a reduction of oligodendroglial lineage cell in the dorsal spinal cord. This defect was mimicked by the bath application of translocator protein (TSPO) agonists and partially rescued by genetic downregulation of TSPO. Cell transplantation experiments showed that requirement of TSPO for MDZ-induced oligodendroglial lineage cell defects is cell-autonomous. Furthermore, transmission electron microscopy and in vivo electrophysiol. recording experiments demonstrated that MDZ exposure caused axon hypomyelination and action potential propagation retardation, resulting in delayed behavior initiation. Thus, our findings reveal that MDZ affects oligodendroglial lineage cell development and myelination in young animals, raising the care about its clinic use in infants and children.
After consulting a lot of data, we found that this compound(498-95-3)Synthetic Route of C6H11NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics