The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.Safety of 1-(tert-Butyl)-1H-pyrrole-2,5-dione.Kumar, Rakesh; Kumar, Rohit; Chandra, Devesh; Sharma, Upendra published the article 《Cp*CoIII-Catalyzed Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Alkylquinolines with Maleimides》 about this compound( cas:4144-22-3 ) in Journal of Organic Chemistry. Keywords: cobalt catalyzed regioselective alkylation alkylquinoline maleimide. Let’s learn more about this compound (cas:4144-22-3).
The cobalt(III)-catalyzed C(sp3)-H bond alkylation of 8-Me quinoline with maleimides is reported. In contrast to the rhodium-catalyzed method, in the current cobalt-catalyzed method, a catalytic amount of acid is used, and importantly, it is also applicable to secondary C(sp3)-H bond alkylation. The developed methodol. is applicable for N-alkyl- and N-aryl-substituted maleimides and unsubstituted maleimides, and it also tolerates the variety of functional groups on the 8-Me quinoline moiety. Atom-economy and high regioselectivity with good to excellent yields of the alkylated products under mild reaction conditions are important features of this method.
The article 《Cp*CoIII-Catalyzed Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Alkylquinolines with Maleimides》 also mentions many details about this compound(4144-22-3)Safety of 1-(tert-Butyl)-1H-pyrrole-2,5-dione, you can pay attention to it, because details determine success or failure
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics