Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Discovery of a new class of inhibitors of vaccinia virus based on (-)-borneol from Abies sibirica and (+)-camphor.SDS of cas: 35836-73-8.
A series of bornyl ester/amide derivatives with N-containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed derivatives, compounds 6, 13, 14, 34, 36, and 37 showed the best inhibitory activity against VV with IC50 values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 μM, resp., and good cytotoxicity. A primary structure-activity relation (SAR) study suggested that the combination of a saturated N-heterocycle, such as morpholine or 4-methylpiperidine, and a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics