So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Peng, Jingjing; Li, Chunpu; Khamrakulov, Mirzadavlat; Wang, Jiang; Liu, Hong researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione.They published the article 《Rhodium(III)-catalyzed C-H alkenylation: Access to maleimide-decorated tryptophan and tryptophan-containing peptides》 about this compound( cas:4144-22-3 ) in Organic Letters. Keywords: maleimide tryptophan synthesis functional groups protecting group solvent effect; peptide maleimide tryptophan macrocyclic synthesis crystal structure; alkenylation rhodium catalyst peptide coupling macrocyclization; drugs fluorescence probe peptide conjugation synthesis alkenylation mechanism. We’ll tell you more about this compound (cas:4144-22-3).
Maleimide is widely applied in many fields, especially in antibody-drug conjugations and peptide drugs. Herein, we develop a strategy for the C-H alkenylation of tryptophan and tryptophan-containing peptides, providing a synthetic route of decorating maleimide on peptides. The method has a high tolerance of functional groups and protecting groups. Furthermore, this method was applied to prepare peptide conjugation with mols. such as drugs and fluorescence probes. Moreover, macrocyclic peptides were obtained via this reaction.
Different reactions of this compound(1-(tert-Butyl)-1H-pyrrole-2,5-dione)Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione require different conditions, so the reaction conditions are very important.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics