Related Products of 35836-73-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Anti-influenza activity of monoterpene-containing substituted coumarins. Author is Khomenko, Tatyana M.; Zarubaev, Vladimir V.; Orshanskaya, Iana R.; Kadyrova, Renata A.; Sannikova, Victoria A.; Korchagina, Dina V.; Volcho, Konstantin P.; Salakhutdinov, Nariman F..
Compounds simultaneously carrying the monoterpene and coumarin moieties have been tested for cytotoxicity and inhibition of activity against influenza virus A/California/07/09 (H1N1)pdm09. The structure of substituents in the coumarin framework, as well as the structure and the absolute configuration of the monoterpenoid moiety, are shown to significantly influence the anti-influenza activity and cytotoxicity of the compounds under study. The compounds with a bicyclic pinane framework exhibit the highest selectivity indexes (the ratios between the cytotoxicity and the active dose). The derivative of (-)-myrtenol 15c (7-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methoxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one), which is characterized by promising activity, low cytotoxicity, and synthetic accessibility, has the greatest potential among this group of compounds It exhibited the highest activity when added to the infected cell culture at early stages of viral reproduction
Different reactions of this compound(2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol)Related Products of 35836-73-8 require different conditions, so the reaction conditions are very important.
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