Month: April 2022

SDS of cas: 498-95-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about Synthesis, characterization, in-silico and in-vitro evaluations of symmetrical 1,3-diketones. Author is Porchezhiyan, V.; Kalaivani, D.; Shobana, J.; Noorjahan, S. E..

The new sym. 1,3-diketones bearing L-proline, 2-methyl-5-iodobenzoic acid, piperidine-3-carboxylic acid and naphthalene-1-acetic acid moieties I, II [R = 5-iodo-2-methyl-Ph, 1-naphthylmethyl], III were synthesized by coupling reaction of appropriate ketone with N-acyl triazole in the presence of MgBr2·Et2O and DIPEA. The chem. structure of the compounds were confirmed from the spectral data such as 1H, 13C-NMR, FT-IR and HRMS. Mol. docking studies were carried out for all the compounds with tumor associated protein tyrosine kinase-6 (PTK6) and inflammatory protein cyclooxygenase-2 (COX2). The in-vitro evaluation was carried out using breast cancer cell lines (MTT assay) and HRBC stabilization assays. During in-silico studies, the ki values obtained against PTK6 and COX2 for I, II [R = 5-iodo-2-methyl-Ph, 1-naphthylmethyl], III compounds were in the range (-7.5 to -10.6) and (-7.6 to -9.8) kcal/mol, resp. The compound II [R = 1-naphthylmethyl] was selected for MTT assay, since it exhibited the highest binding affinity (-10.6 kcal/mol) against PTK6 and gave IC50 – 2.4μg/mL against breast cancer cell lines. The HRBC stabilization of all the compounds I, II [R = 5-iodo-2-methyl-Ph, 1-naphthylmethyl], III were in the range (59.28-93.4) %, with highest stabilization value by compound II [R = 1-naphthylmethyl], which also displayed higher binding affinity with -7.6 kcal/mol towards COX2. Thus, the synthesized sym. 1,3-diketones I, II [R = 5-iodo-2-methyl-Ph, 1-naphthylmethyl], III with suitable functionality can be both anticancer and anti-inflammatory agents.

The article 《Synthesis, characterization, in-silico and in-vitro evaluations of symmetrical 1,3-diketones》 also mentions many details about this compound(498-95-3)SDS of cas: 498-95-3, you can pay attention to it, because details determine success or failure

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Cyclopropanation of Terminal Alkenes through Sequential Atom-Transfer Radical Addition/1,3-Elimination, published in 2019, which mentions a compound: 35836-73-8, mainly applied to cyclopropane derivative preparation; terminal alkene cyclopropanation radical addition; alkenes; cyclopropanation; iodine; organoboron compounds; radical reactions, Category: chlorides-buliding-blocks.

An operationally simple method to affect an atom-transfer radical addition of com. available ICH2Bpin to terminal alkenes has been developed. The intermediate iodide can be transformed in a one-pot process into the corresponding cyclopropane upon treatment with a fluoride source. This method is highly selective for the cyclopropanation of unactivated terminal alkenes over non-terminal alkenes and electron-deficient alkenes. Due to the mildness of the procedure, a wide range of functional groups such as esters, amides, alcs., ketones, and vinylic cyclopropanes are well tolerated.

The article 《Cyclopropanation of Terminal Alkenes through Sequential Atom-Transfer Radical Addition/1,3-Elimination》 also mentions many details about this compound(35836-73-8)Category: chlorides-buliding-blocks, you can pay attention to it, because details determine success or failure

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Dalton Transactions called Thin film formation of platinum nanoparticles at oil-water interface, using organoplatinum(II) complexes, suitable for electro-oxidation of methanol, Author is Hoseini, S. Jafar; Mousavi, Neda; Roushani, Mahmoud; Mosaddeghi, Leila; Bahrami, Mehrangiz; Rashidi, Mehdi, which mentions a compound: 12266-72-7, SMILESS is I[Pt]I.C1=CCC/C=CCC/1, Molecular C8H12I2Pt, Quality Control of Diiodo(1,5-cyclooctadiene)platinum(II).

A simple and effective strategy is presented to integrate individual Pt nanoparticles (NPs) into macroscopic thin films based on the reduction of organoplatinum(II) complexes [PtCl2(cod)] 1a, [PtI2(cod)] 1b (cod = 1,5-cyclooctadiene) and cis-[Pt(p-MeC6H4)2(SMe2)2] 2, at the toluene-H2O interface in the absence of stabilizer. Structure and morphol. of the Pt NPs were characterized with XRD, TEM, and SAED. Finally, Pt thin films were deposited on glassy C electrode and their electrooxidation was studied in the MeOH oxidation reaction. Pt NPs thin films showed highly improved electrocatalytic activity toward MeOH oxidation as compared with com. Pt catalysts. The present method provides a facile and low-cost strategy toward the synthesis of different electrocatalysts of noble metals for application in fuel cells.

The article 《Thin film formation of platinum nanoparticles at oil-water interface, using organoplatinum(II) complexes, suitable for electro-oxidation of methanol》 also mentions many details about this compound(12266-72-7)Quality Control of Diiodo(1,5-cyclooctadiene)platinum(II), you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

COA of Formula: C8H11NO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Syntheses of some N-alkylmaleimides. Author is Wang, Z. Y..

Secondary and tertiary maleimides I (R = cyclohexyl, Me3C, Me3CCH2CMe2) were prepared by treating maleic anhydride with RNH2 to give HO2CCH:CHCONH2, which were cyclized by treatment with Et3N/Ac2O in Me2CO or MeCOEt.

The article 《Syntheses of some N-alkylmaleimides》 also mentions many details about this compound(4144-22-3)COA of Formula: C8H11NO2, you can pay attention to it, because details determine success or failure

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.Safety of 1-(tert-Butyl)-1H-pyrrole-2,5-dione.Kumar, Rakesh; Kumar, Rohit; Chandra, Devesh; Sharma, Upendra published the article 《Cp*CoIII-Catalyzed Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Alkylquinolines with Maleimides》 about this compound( cas:4144-22-3 ) in Journal of Organic Chemistry. Keywords: cobalt catalyzed regioselective alkylation alkylquinoline maleimide. Let’s learn more about this compound (cas:4144-22-3).

The cobalt(III)-catalyzed C(sp3)-H bond alkylation of 8-Me quinoline with maleimides is reported. In contrast to the rhodium-catalyzed method, in the current cobalt-catalyzed method, a catalytic amount of acid is used, and importantly, it is also applicable to secondary C(sp3)-H bond alkylation. The developed methodol. is applicable for N-alkyl- and N-aryl-substituted maleimides and unsubstituted maleimides, and it also tolerates the variety of functional groups on the 8-Me quinoline moiety. Atom-economy and high regioselectivity with good to excellent yields of the alkylated products under mild reaction conditions are important features of this method.

The article 《Cp*CoIII-Catalyzed Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Alkylquinolines with Maleimides》 also mentions many details about this compound(4144-22-3)Safety of 1-(tert-Butyl)-1H-pyrrole-2,5-dione, you can pay attention to it, because details determine success or failure

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sharma, Satyasheel; Oh, Yongguk; Mishra, Neeraj Kumar; De, Umasankar; Jo, Hyeim; Sachan, Richa; Kim, Hyung Sik; Jung, Young Hoon; Kim, In Su published the article 《Rhodium-Catalyzed [3 + 2] Annulation of Cyclic N-Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones》. Keywords: spiroisoindolinone preparation antitumor; hydroxyisoindolinone preparation olefin cyclization; phthalimide Grignard reagent.They researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).HPLC of Formula: 4144-22-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4144-22-3) here.

The rhodium(III)-catalyzed redox-neutral coupling reaction of N-acyl ketimines generated in situ from 3-hydroxyisoindolinones with various activated olefins is described. This approach leads to the synthesis of bioactive spiroisoindolinone derivatives in moderate to high yields. In the case of internal olefins such as maleimides, maleates, fumarates, and cinnamates, spiroindanes were obtained by the [3 + 2] annulations reaction. In sharp contrast, acrylates and quinones displayed the β-H elimination followed by Prins-type cyclization furnishing spiroindenes. The synthetic compounds were evaluated for in vitro anticancer activity against androgen-sensitive human prostate adenocarcinoma cells (LNCaP), human prostate adenocarcinoma cells (DU145), human endometrial adenocarcinoma cells (Ishikawa), human breast cancer cell (MCF-7), and triple neg. human breast cancer cells (MDA-MB-231). Notably, quinone-containing spiroindenes displayed potent anticancer activity about 2- to 3-fold stronger than that of anticancer agent doxorubicin.

The article 《Rhodium-Catalyzed [3 + 2] Annulation of Cyclic N-Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones》 also mentions many details about this compound(4144-22-3)HPLC of Formula: 4144-22-3, you can pay attention to it, because details determine success or failure

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Cluster Science called Platinum(II)-silver(I) polymers bearing platinum(II) clusters containing chelated P,P- and bridged P,N-2-pyridylphosphine ligands, Author is Jones, Nathan D.; Rettig, Steven J.; James, Brian R., which mentions a compound: 12266-72-7, SMILESS is I[Pt]I.C1=CCC/C=CCC/1, Molecular C8H12I2Pt, HPLC of Formula: 12266-72-7.

Reactions of PtI2L [L = P,P-bonded 1,2-bis((2-pyridyl)phosphino)ethane, d(py)pe, or 1,2-bis((2-pyridyl)phosphino)cyclopentane, d(py)pcp] with excess AgNO3 in acetic acid/ethanol afford the polymers {[Pt2(d(py)pe)2Ag4(NO3)8]·2H2O}n (1) and [Pt2(d(py)pcp)2Ag6(NO3)10]n (2), resp., which contain (Pt2L2)4+ cores with each L ligand now P,N-bridging two Pt-atoms; these Pt2 cores are connected via bridging AgNO3 clusters, the Ag being bound to the pyridyl-N or nitrate-O atoms. X-ray crystallog. data reveal Pt-Pt contacts of ∼2.76 Å indicative of bonding.

The article 《Platinum(II)-silver(I) polymers bearing platinum(II) clusters containing chelated P,P- and bridged P,N-2-pyridylphosphine ligands》 also mentions many details about this compound(12266-72-7)HPLC of Formula: 12266-72-7, you can pay attention to it, because details determine success or failure

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and biological evaluation of α- and β-hydroxy substituted amino acid derivatives as potential mGAT1-4 inhibitors, published in 2020-08-31, which mentions a compound: 498-95-3, Name is Piperidine-3-carboxylic acid, Molecular C6H11NO2, Name: Piperidine-3-carboxylic acid.

Abstract: In this study, we report the synthesis and biol. evaluation of a variety of α- and β-hydroxy substituted amino acid derivatives as potential amino acid subunits in inhibitors of GABA uptake transporters (GATs). In order to ensure that the test compounds adopt a binding pose similar to that presumed for related larger GAT inhibitors, lipophilic residues were introduced either at the amino nitrogen atom or at the alc. function. Several of the synthesized compounds were found to exhibit similar inhibitory activity at the GAT subtypes mGAT2, mGAT3, and mGAT4, resp., as compared with the reference N-butylnipecotic acid. Hence, these compounds might serve as starting point for future developments of more complex GAT inhibitors.

The article 《Synthesis and biological evaluation of α- and β-hydroxy substituted amino acid derivatives as potential mGAT1-4 inhibitors》 also mentions many details about this compound(498-95-3)Name: Piperidine-3-carboxylic acid, you can pay attention to it, because details determine success or failure

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3,3′-Diindolylmethane(SMILESS: C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4,cas:1968-05-4) is researched.Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The article 《Diindolylmethane alleviates acute atopic dermatitis by regulating T cell differentiation in a mouse model》 in relation to this compound, is published in Molecular Immunology. Let’s take a look at the latest research on this compound (cas:1968-05-4).

Atopic dermatitis is a severe, chronic relapsing inflammatory disease of the skin with family clustering. It is characterized into acute phase, which is dominated by T helper 2-type immune responses, and chronic phase, which is dominated by T helper 1-type immune responses. Studies have shown that 3,3-diindolylmethane not only has antitumor effects but also can relieve symptoms of inflammatory diseases by inhibiting the nuclear factor-κB signaling pathway and regulating T cell differentiation. To study the effect of 3,3-diindolylmethane on atopic dermatitis and the underlying mechanism, a mouse model of acute atopic dermatitis was established using 2,4-dinitrofluorobenzene. After i.p. injection of 3,3-diindolylmethane, skin erythema and edema in mice were significantly alleviated. Furthermore, 3,3-diindolylmethane reduced immune activation, probably by inhibiting the secretion of thymic stromal lymphopoietin by keratinocytes. 3,3-Diindolylmethane also promoted the differentiation of regulatory T cells and inhibited the activation of T helper 2 and T helper 17 cells to reduce atopic dermatitis-related immune responses. However, it showed no significant effect on the differentiation of T helper 1 cells. These results indicate that 3,3-diindolylmethane has a significant inhibitory effect on T helper 2 cells in the acute phase of atopic dermatitis. Our findings may provide not only more insights into the pathol. mechanism of AD, but also a new candidate medicine for it.

The article 《Diindolylmethane alleviates acute atopic dermatitis by regulating T cell differentiation in a mouse model》 also mentions many details about this compound(1968-05-4)Recommanded Product: 3,3′-Diindolylmethane, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4144-22-3, is researched, SMILESS is O=C(C=C1)N(C(C)(C)C)C1=O, Molecular C8H11NO2Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called Ruthenium(II)-Catalyzed C-H Activation of Chromones with Maleimides to Synthesize Succinimide/Maleimide-Containing Chromones, Author is Zhou, Yan; Liang, Hong; Sheng, Yaoguang; Wang, Shaoli; Gao, Yi; Zhan, Lingling; Zheng, Zhilong; Yang, Mengjie; Liang, Guang; Zhou, Jianmin; Deng, Jun; Song, Zengqiang, the main research direction is maleimide regioselective divergent hydroarylation Heck coupling chromone ruthenium catalyst; chromone maleimide succinimide hybrid preparation.Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione.

An efficient route for the coupling of maleimides with chromones at the C5-position was developed under Ru(II) catalysis. By switching additives, either 1,4-addition products or oxidative Heck-type products were obtained. Benzoic acid led to the formation of 1,4-addition products under solvent-free conditions and silver acetate promoted the generation of oxidative Heck-type products. Various maleimides and chromones were suitable for this transformation, affording the desired products in good to excellent yields in a short reaction time. To understand the mechanism of this reaction, deuteration studies and control experiments were performed.

After consulting a lot of data, we found that this compound(4144-22-3)Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics