Month: April 2022

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Synthesis of P-Stereogenic Phosphorus Compounds. Asymmetric Oxidation of Phosphines under Appel Conditions.Electric Literature of C11H18O.

Asym. oxidation of racemic tertiary phosphines Ph(Me)RP to the corresponding chiral phosphine oxides (R)- and (S)-Ph(Me)RPO (R = 2-MeOC6H4, 2-MeC6H4, 2-iPrC6H4, 2-ClC6H4, tBu) was achieved in Appel conditions by reaction with chiral alc. [(-)-menthol, (+)-neomenthol, (+)-isomenthol, (-)-8-phenylmenthol, (+)-trans-2-tert-butylcyclohexanol] and hexachloroacetone or CCl4; the process was applied for preparation of (R,R)-1,2-bis[(o-anisyl)phenylphosphino]ethane (DiPAMP). α-Lithiation of (R)-Ph(Me)(2-MeOC6H4)PO followed by copper-catalyzed homocoupling gave (R,R)-Ph(2-MeOC6H4)P(O)CH2CH2P(O)Ph(2-MeOC6H4) [(R,R)-DiPAMPO] with 92% yield. Racemic phosphines are converted into enantioenriched phosphine oxides via a synthetically simple, but theor. interesting, oxidation procedure in good enantiomeric excess (up to 80%) and excellent yields (>95%). Particularly attractive aspects of this procedure are the operational simplicity and the low cost required to synthesize these high value compounds

After consulting a lot of data, we found that this compound(35836-73-8)Electric Literature of C11H18O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Hydroformylation of biomass-based hydroxyolefins in eco-friendly solvents: New fragrances from myrtenol and nopol, published in 2019-01-31, which mentions a compound: 35836-73-8, mainly applied to fragrance preparation hydroformylation myrtenol nopol, Electric Literature of C11H18O.

The hydroformylation of the naturally occurring hydroxyolefins (1R)-(-)-myrtenol and (1R)-(-)-nopol was performed employing a rhodium(I)/bulky phosphite catalytic system. Both substrates demonstrated to be quite reluctant to hydroformylation and revealed a strong tendency to form isomeric saturated aldehydes under hydroformylation conditions. In spite of these challenges, catalytic systems and conditions were found to allow the synthesis of corresponding hydroxyaldehydes. The products, either isolated or as a mixture, presented a pleasant smell and are potentially useful as fragrances. In addition, it was possible to perform the reactions in eco-friendly solvents.

After consulting a lot of data, we found that this compound(35836-73-8)Electric Literature of C11H18O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Preparation of campholenal analogs: chirons for the lipophilic moiety of sandalwood-like odorant alcohols., published in 1992-08-13, which mentions a compound: 35836-73-8, Name is 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, Molecular C11H18O, Electric Literature of C11H18O.

In connection with structure-activity relationship studies, analogs of campholenal [(+)-I; R = Me], an important building block for sandalwood-like odorants, were prepared The five-membered-ring analogs I [R = Et, Pr, Bu, CH2CH2OR’, CH2CH2COMe, CH:CH2, CH2CH2CO2Et, CH2OMe, CH2OEt, CH2CH2CH2CO2Me, R’ = H, Me, SO2C6H4Me-p] were obtained by epoxidation of the corresponding α-pinene derivatives II, followed by catalytic ZnBr2 isomerization. The six-membered-ring skeleton III was obtained by ozonolysis of α-campholenyl acetate [(-)-IV], followed by intramol. aldol condensation. 13C-NMR assignments are given.

After consulting a lot of data, we found that this compound(35836-73-8)Electric Literature of C11H18O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Heteroleptic platinum(II) complexes of macrocyclic thioethers and halides: the crystal structures of [Pt(9S3)Cl2], [Pt(9S3)Br2], and [Pt(9S3)I2].Formula: C8H12I2Pt.

The synthesis, spectroscopic, and crystal structures of three heteroleptic thioether/halide Pt(II) complexes [Pt(9S3)X2] (9S3 = 1,4,7-trithiacyclononane, X = Cl-, Br-, I-) are presented. All three 9S3/dihalo complexes form very similar structures in which the Pt(II) center is surrounded by a cis arrangement of two halides and two S atoms from the 9S3 ligand. The third S from the 9S3 forms a long distance interaction with the Pt center resulting in an elongated square pyramidal structure with a S2X2+S1 coordination geometry. The distances between the Pt(II) center and axial S shorten with larger halide ions (Cl- = 3.260(3) Å > Br- = 3.243(2) Å > I- = 3.207(2) Å). These distances are consistent with the halides functioning as π donor ligands, and their Pt-S axial distances fall intermediate between Pt(II) thioether complexes involving π acceptor and σ donor ligands. The 195Pt NMR chem. shift values follow a similar trend with an increased shielding of the Pt ion with larger halide ions. The 9S3 ligand is fluxional in all of these complexes, producing a single carbon resonance in the 13C NMR spectra. Addnl., a related series of homoleptic crown thioether complexes were studied using 195Pt NMR, and there is a strong correlation between the chem. shift and complex structure. Homoleptic crown thioethers show the anticipated upfield chem. shifts with increasing number of coordinated sulfurs. Complexes containing four coordinated S donors have chem. shifts that fall at -4000 to -4800 ppm while a value near -5900 ppm is indicative of five coordinated sulfurs. However, for S4 crown thioether complexes, differences in the stereochem. orientation of lone pair electrons on the S donors can greatly influence the observed 195Pt NMR chem. shifts, often by several hundred ppm.

After consulting a lot of data, we found that this compound(12266-72-7)Formula: C8H12I2Pt can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Penta, Dhanamjai; Mondal, Priya; Natesh, Jagadish; Meeran, Syed Musthapa researched the compound: 3,3′-Diindolylmethane( cas:1968-05-4 ).SDS of cas: 1968-05-4.They published the article 《Dietary bioactive diindolylmethane enhances the therapeutic efficacy of centchroman in breast cancer cells by regulating ABCB1/P-gp efflux transporter》 about this compound( cas:1968-05-4 ) in Journal of Nutritional Biochemistry. Keywords: dietary bioactive diindolylmethane centchroman breast cancer ABCB efflux transporter; ABCC1/MRP1; Breast cancer; Combinatorial therapy; Drug efflux; Molecular docking; P-glycoprotein. We’ll tell you more about this compound (cas:1968-05-4).

Overexpression of drug efflux transporters is commonly associated with multidrug-resistance in cancer therapy. Here for the first time, we investigated the ability of diindolylmethane (DIM), a dietary bioactive rich in cruciferous vegetables, in enhancing the efficacy of Centchroman (CC) by modulating the drug efflux transporters in human breast cancer cells. CC is a selective estrogen receptor modulator, having promising therapeutic efficacy against breast cancer. The combination of DIM and CC synergistically inhibited cell proliferation and induced apoptosis in breast cancer cells. This novel combination has also hindered the stemness of human breast cancer cells. Mol. docking anal. revealed that DIM had shown a strong binding affinity with the substrate-binding sites of ABCB1 (P-gp) and ABCC1 (MRP1) drug-efflux transporters. DIM has increased the intracellular accumulation of Hoechst and Calcein, the substrates of P-gp and MRP1, resp., in breast cancer cells. Further, DIM stimulates P-gp ATPase activity, which indicates that DIM binds at the substrate-binding domain of P-gp, and thereby inhibits its efflux activity. Intriguingly, DIM enhanced the intracellular concentration of CC by inhibiting the P-gp and MRP1 expression as well as activity. The intracellular retaining of CC has increased its efficacy against breast cancer. Overall, DIM, a dietary bioactive, enhances the anticancer efficiency of CC through modulation of drug efflux ABC-transporters in breast cancer cells. Therefore, DIM-based nutraceuticals and functional foods can be developed as adjuvant therapy against human breast cancer.

After consulting a lot of data, we found that this compound(1968-05-4)SDS of cas: 1968-05-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about A crystalline, internally-coordinated chloroborane for asymmetric hydroboration. Author is von Dollen, Breanna; Wood, John L.; Savage, Quentin R.; Jones, Andrew J.; Garner, Charles M..

Here was reported the preparation of a unique chiral chloroborane-internal ether complex and its applications in asym. hydroboration. This chloroborane was easily obtained in crystalline, solvent-free and enantiomerically pure form. The chem. shift of the Lewis-basic methoxy group was sensitive to the boron environment, making this reagent especially amenable to NMR studies in which diastereomer ratios can, in many cases, be determined before oxidation, and even kinetics are relatively easily carried out. It reacted readily with prochiral alkenes to give, after oxidation, alcs. in up to 82% ee. The dialkylchloroborane intermediates could be diastereomerically purified by recrystallization either directly, or as air-stable ethanolamine complexes, to give after oxidation alcs. in up to 99.8% ee. The chloro group was easily replaced by hydride in-situ, allowing for intramol. asym. hydroborations and deuteroborations with a high degree of regiochem. control that intermol. hydroborations cannot provide.

After consulting a lot of data, we found that this compound(35836-73-8)Application In Synthesis of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

COA of Formula: C8H12I2Pt. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Reversible transformation of 10-P-3 ADPO to an 8-P-3 ADPO·PtI2 adduct. Author is Arduengo, Anthony J. III; Stewart, Constantine A.; Davidson, Fredric.

The synthesis and characterization of I, derived from 10-P-3 ADPO, is described. Multinuclear NMR spectra reveal an electronic and geometric reorganization of the ADPO ring system from planar in the uncomplexed ligand to bent in the metal-ADPO complex.

After consulting a lot of data, we found that this compound(12266-72-7)COA of Formula: C8H12I2Pt can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

McMahon, Kevin; Wagner, Peter J. published the article 《Intramolecular photosensitization of the pinene-ocimene rearrangement》. Keywords: intramol photosensitization pinene ocimene rearrangement.They researched the compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8 ).Application of 35836-73-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:35836-73-8) here.

Bonding of nopol to the para position of acetophenone produces 6,6-dimethyl-2-(2-(p-acetylphenoxy)ethyl)bicyclo[3.1.1]hept-2-ene 1, which contains two chromophores: a para-alkoxyacetophenone and an α-pinene, connected by a single methylene group. UV irradiation of 1 in both benzene and methanol produces none of the intramol. [2 + 2] cycloaddition that most para-(3-buten-1-oxy)acetophenones undergo. Instead, the pinene unit rearranges to a triene skeleton identical to that of ocimene, a known photoproduct of pinene. At modest conversion the diene portion of the triene is cis but gradually is converted to a 52:48 trans:cis ratio. It is concluded that intramol. triplet energy transfer from the excited ketone chromophore forms the 1,2-biradical triplet state of the pinene moiety, which then undergoes cyclobutylcarbinyl ring opening to a 1,4-biradical that cleaves to the 1,3,6-triene structure of ocimene. This mechanism is suggested to be responsible for the earlier reported intermolecularly sensitized rearrangement of α-pinene to the ocimene isomers.

After consulting a lot of data, we found that this compound(35836-73-8)Application of 35836-73-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: 35836-73-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Microbial transformation of (-)-nopol benzyl ether: direct dihydroxylation of benzene ring. Author is Noma, Yoshiaki; Asakawa, Yoshinori.

The biotransformation of (-)-nopol benzyl ether (5) by Aspergillus niger TBUYN-2 and A. niger Tiegh CBSYN was investigated. A. niger biotransformed 5 to afford (-)-4-oxonopol-2′,4′-dihydroxybenzyl ether (6), and (-)-4-oxonopol (7) as main products. Compound 6 showed strong antioxidant activity (IC50 30.2 μM), which was very similar to that of Bu hydroxyl anisole (BHA).

After consulting a lot of data, we found that this compound(35836-73-8)HPLC of Formula: 35836-73-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Electrochemical [4+2] Annulation-Rearrangement-Aromatization of Styrenes: Synthesis of Naphthalene Derivatives, published in 2019, which mentions a compound: 498-95-3, Name is Piperidine-3-carboxylic acid, Molecular C6H11NO2, Synthetic Route of C6H11NO2.

We report the first electrochem. strategy to synthesize functionalized naphthalene derivatives through [4+2] annulation-rearrangement-aromatization from styrenes under mild conditions [e.g., 4-methoxy-α-methylstyrene → 7-methoxy-2-(4-methoxyphenyl)-1,4-dimethylnaphthalene (67%)]. The electrolysis does not require metals, oxidants and high valence substrates, indicating the atom and step-economy ideals. The dehydrodimer produced through [4+2] cycloaddition of 4-methoxy-α-methylstyrene is isolated and proved to be the key intermediate for the following oxydehydrogenation to form carbon cation, which undergoes rearrangement-aromatization to afford the final products. This reaction represents a powerful access to construct multi-substituted naphthalene blocks in a single step.

After consulting a lot of data, we found that this compound(498-95-3)Synthetic Route of C6H11NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics