Month: April 2022

Perosa, Alvise; Tundo, Pietro; Zinovyev, Sergei published an article about the compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8,SMILESS:CC1(C)[C@@]2([H])CC=C(CCO)[C@]1([H])C2 ).Safety of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:35836-73-8) through the article.

A preliminary study was conducted on the multiphase (aqueous KOH-isooctane-Aliquat 336) hydrogenolysis of benzyl Me ether using Pd/C, Pt/C and Raney-Ni as catalysts, under mild conditions (T=50°, pH2=1 atm). Using ethanol as solvent, the Pd/C system is efficient, while the same catalyst under multiphase conditions is almost inactive. With Pt/C, the reaction is always sluggish, and ring hydrogenation kicks in under multiphase conditions. The Raney-Ni system has an opposite behavior, while debenzylation is slow in ethanol, under multiphase conditions the reaction is quite fast. Other O-benzyl protected substrates undergo debenzylation with Raney-Ni as well, with varying chemoselectivity.

After consulting a lot of data, we found that this compound(35836-73-8)Safety of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 4144-22-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Cobalt(III)-catalyzed cross-coupling of enamides with allyl acetates/maleimides. Author is Yu, Wenlong; Zhang, Wei; Liu, Yue; Liu, Zhanxiang; Zhang, Yuhong.

Cp*Co(III)-catalyzed direct allylation of enamides RC(=CH2)NHC(O)CH3 (R = C6H5, 2-thienyl, 2-naphthyl, etc.) has been accomplished with the exclusive formation of allylated Z-enamides RC(=CHCH2CH=CH2)NHC(O)CH3 with high efficiency. In addition, the employment of maleimides I (R2 = H, Cy, Ph, etc.) as the reaction partner under the same catalytic conditions provides a series of succinimide-substituted Z-enamides II (R1 = C6H5, 2-thienyl, 1-naphthyl, etc.).

After consulting a lot of data, we found that this compound(4144-22-3)Application of 4144-22-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Cancer Letters (New York, NY, United States) called Novel COX1/2 and ERK1/2 inhibitor 3,3′-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2, Author is Tian, Xueli; Liu, KangDong; Zu, Xueyin; Ma, Fayang; Li, Zhi; Lee, MeeHyun; Chen, Hanyong; Li, Yan; Zhao, Yuzhou; Liu, Fangfang; Oi, Naomi; Bode, Ann M.; Dong, Zigang; Kim, Dong Joon, which mentions a compound: 1968-05-4, SMILESS is C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4, Molecular C17H14N2, Application In Synthesis of 3,3′-Diindolylmethane.

3,3′-Diindolymethane (DIM) is a dimeric condensation product of indole-3-carbinol (I3C) that is found in broccoli and cabbage. Although DIM has been reported to exhibit anticancer properties against multiple tumor types, the direct target proteins of DIM have not been fully investigated. In the present study, we report that DIM is a novel COX1/2 and ERK1/2 inhibitor that suppresses growth of colon cancer in vitro and in vivo. To identify possible mol. targets of DIM, 11 potential candidate proteins were validated by an in vitro kinase or enzyme assay. We found that DIM directly inhibits COX1/2 and ERK1/2 protein activities in vitro. Addnl., the PGE2 production (COX-mediated metabolite) and phosphorylated RSK expression (ERK1/2 direct downstream kinase) were strongly suppressed by DIM in colon cancer cells. The inhibition of cell growth by DIM is dependent on the expression of COX1/2 or ERK1/2 proteins. Notably, oral administration of DIM suppressed patient-derived xenograft colon tumor growth in an in vivo mouse model. Overall these results suggest that DIM is a potent and dual COX1/2 and ERK1/2 inhibitor that might be used for chemotherapy against colon cancer.

After consulting a lot of data, we found that this compound(1968-05-4)Application In Synthesis of 3,3′-Diindolylmethane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of Diiodo(1,5-cyclooctadiene)platinum(II). The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Formation of metallamacrocycles from palladium(II), platinum(II) and copper(I) complexes and the ditopic ligands [{p-(Ph2PO)C6H4}2CMe2], [{2-Ph2PO-3,5-(Me3C)2C6H2}2S], [{p-[(C10H6O)2PO]C6H4}2CMe2]. Author is Arena, Carmela Grazia; Drommi, Dario; Faraone, Felice; Graiff, Claudia; Tiripicchio, Antonio.

The new ligands bis(phosphinito) [{2-Ph2PO-3,5-(Me3C)2C6H2}2S] (4) and chiral bis(phosphite) [{p-[(C10H6O)2PO]C6H4}2CMe2] (5) were synthesized and their reactions with Pd(II), Pt(II), Cu(I) substrates were studied. [{P-(Ph2PO)C6H4}2CMe2] (3), previously reported by the authors, was also used in the same reactions. Ligands 3 and 5 formed 28-membered metallamacrocycles while ligand 4 afforded the analogous compound only in the reaction with the Cu(I) substrate. In the reaction of 3 with [Pd(PhCN)2Cl2] the metallamacrocycle [PdCl2(μ-3)]2 (6) or the oligomer [Pd2Cl4(μ-3)]n (7) were formed, depending on the molar ratio used. The reaction of 3 with [Pd(η3-C3H5)Cl]2 afforded {[Pd(η3-C3H5)Cl]2(μ-3)} (8). The allylpalladium macrocycle [Pd(η3-C3H5)(μ-3)]2[OTf]2 (9) was obtained by treating a solution of 8 in THF with AgCF3SO3. The reactions of 3 with [Pt(COD)I2] or [Cu(NCCH3)4]BF4 gave metallamacrocycles [PtI2(μ-3)]2 (10) and [Cu2(μ-3)2][BF4]2·2MeCN (11), resp. The structure of 10 was also elucidated by x-ray anal. Reactions of 4 with Pd(II) and Pt(II) complexes afforded a mixture of two very different compounds in almost an equimolar ratio. An x-ray anal. established that one is a mononuclear compound, formed by modification of the ligand 4, containing a P,S-chelate, [PdCl2{[2-Ph2PO-3,5(Me3C)2C6H2][3,5-(Me3C)2C6H2OH]S}] (12). The reaction between [Cu(NCCH3)4]BF4 and 4 afforded the ionic metallamacrocycle [Cu(μ-4)][BF4]2·2MeCN (14). In compound 10, the size of the central cavity formed by the bridging ligand 3 was determined

After consulting a lot of data, we found that this compound(12266-72-7)Application In Synthesis of Diiodo(1,5-cyclooctadiene)platinum(II) can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C6H11NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator. Author is Rennie, Glen R.; Barden, Timothy C.; Bernier, Sylvie G.; Carvalho, Andrew; Deming, Renee; Germano, Peter; Hudson, Colleen; Im, G-Yoon J.; Iyengar, Rajesh R.; Jia, Lei; Jung, Joon; Kim, Elise; Lee, Thomas W.-H.; Mermerian, Ara; Moore, Joel; Nakai, Takashi; Perl, Nicholas R.; Tobin, Jenny; Zimmer, Daniel P.; Renhowe, Paul A..

Soluble guanylate cyclase (sGC) is a clin. validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC have the potential to treat diseases that are affected by dysregulation of the NO-sGC-cGMP signal transduction pathway. This letter describes the SAR efforts that led to the discovery of CYR715, a novel carboxylic acid-containing sGC stimulator, with an improved metabolic profile relative to our previously described stimulator, IWP-051. CYR715 addressed potential idiosyncratic drug toxicity (IDT) liabilities associated with the formation of reactive, migrating acyl glucuronides (AG) found in related carboxylic acid-containing analogs and demonstrated high oral bioavailability in rat and dose-dependent hemodynamic pharmacol. in normotensive Sprague-Dawley rats.

After consulting a lot of data, we found that this compound(498-95-3)Computed Properties of C6H11NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Thermal degradation of vinylidene chloride/vinyl chloride copolymers in the presence of N-substituted maleimides.

As a consequence of their excellent barrier properties vinyl chloride/vinylidene chloride copolymers have long been prominent in the flexible packaging market. While these polymers possess a number of superior characteristics, they tend to undergo thermally-induced degradative dehydrochlorination at process temperatures This degradation must be controlled to permit processing of the polymers. Three series of N-substituted maleimides (N-alkyl-, N-aralkyl, and N-aryl) have been synthesized, characterized spectropically, and evaluated as potential stabilizers for a standard vinyl chloride/vinylidene chloride (85 weight percent) copolymer. As surface blends with the polymer, these compounds are ineffective as stabilizers. However, significant stabilization may be achieved by pretreatment of the polymer with N-substituted maleimides. The most effective stabilization of the polymer is afforded by N-aralkyl- or N-arylmaleimides, most notably, N-benzylmaleimide and N-p-methoxyphenylmaleimide.

After consulting a lot of data, we found that this compound(4144-22-3)Application In Synthesis of 1-(tert-Butyl)-1H-pyrrole-2,5-dione can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Piperidine-3-carboxylic acid(SMILESS: O=C(C1CNCCC1)O,cas:498-95-3) is researched.Formula: C8H12I2Pt. The article 《Midazolam Exposure Impedes Oligodendrocyte Development via the Translocator Protein and Impairs Myelination in Larval Zebrafish》 in relation to this compound, is published in Molecular Neurobiology. Let’s take a look at the latest research on this compound (cas:498-95-3).

Anesthetics are commonly used in various medical procedures. Accumulating evidence suggests that early-life anesthetics exposure in infants and children affects brain development, causing psychiatric and neurol. disorders. However, the underlying mechanisms are poorly understood. Using zebrafish larvae as a model, we found that the proliferation and migration of oligodendrocyte progenitor cells (OPCs) were severely impaired by the exposure of midazolam (MDZ), an anesthetic widely used in pediatric surgery and intensive care medicine, leading to a reduction of oligodendroglial lineage cell in the dorsal spinal cord. This defect was mimicked by the bath application of translocator protein (TSPO) agonists and partially rescued by genetic downregulation of TSPO. Cell transplantation experiments showed that requirement of TSPO for MDZ-induced oligodendroglial lineage cell defects is cell-autonomous. Furthermore, transmission electron microscopy and in vivo electrophysiol. recording experiments demonstrated that MDZ exposure caused axon hypomyelination and action potential propagation retardation, resulting in delayed behavior initiation. Thus, our findings reveal that MDZ affects oligodendroglial lineage cell development and myelination in young animals, raising the care about its clinic use in infants and children.

After consulting a lot of data, we found that this compound(498-95-3)Synthetic Route of C6H11NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Preparation and properties of hydroxo(methyl)-1,2-bis(diphenylphosphino)ethaneplatinum(II). A trans-influence series including σ carbon donor ligands based on platinum-phosphorus coupling constants》. Authors are Appleton, T. G.; Bennett, M. A..The article about the compound:Diiodo(1,5-cyclooctadiene)platinum(II)cas:12266-72-7,SMILESS:I[Pt]I.C1=CCC/C=CCC/1).Formula: C8H12I2Pt. Through the article, more information about this compound (cas:12266-72-7) is conveyed.

Monomeric Pt(OH)(Me)(dppe) (I; dppe = 1,2-bis(diphenylphosphino)ethane) is obtained from PtCl(Me)(dppe) by treatment of the derived labile cation [Pt(MeOH)(Me)(dppe)]+ with aqueous methanolic NaOH. I undergoes anation with a variety of acids, including fairly weak acids such as Me2CO and MeCN, and provides a convenient route to unsym. bis(alkyls) of Pt(II), e.g., Pt(CH2COMe)(Me)(dppe) and Pt(CH2CN)(Me)(dppe). The values of JPtPtrans to X or L derived from the 31P{1H} NMR spectra of PtXR(dppe) (X = various anionic ligands and R = Me or 1-cyclohexenyl), [Pt(Me)L(dppe)]+ (L = various neutral ligands), and sundry other neutral complexes of the type PtXY(dppe), permit the establishment of a trans-influence series which includes OH- and a variety of σ C donors. The OH- has a trans influence comparable with those of typical S donors and higher than those of NO3- and CH3CO2-. The generally high trans influence of σ C donors is lowered by the presence of conjugated electron-withdrawing groups on the ligating C atom. Tricyanomethide, C(CN)3-, binds through N rather than C, and C-bonded triacetylmethyl, C(COCH3)3-, is only slightly higher than Cl- in the trans-influence series, whereas the trans influence of CF3- is high and only slightly less than that of CH3-. In contrast, the Pt-Cl bond length and stretching frequency data indicate the trans influence of CF3- to be considerably lower than that of CH3-. The discrepancy is thought to arise because of the JPtPvalues primarily reflect changes in hybridization, whereas the Pt-Cl bond parameters are also sensitive to electrostatic effects induced by the electroneg. F atoms.

After consulting a lot of data, we found that this compound(12266-72-7)Formula: C8H12I2Pt can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 1968-05-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Rapid measurement of indole levels in Brassica vegetables using one millilitre binary organic extraction solvent and capillary electrophoresis-UV analysis.

Introduction : Brassica vegetables contain high levels of indole compounds which have been found to provide health benefits, especially as cancer-preventive agents. An efficient and rapid method using solvent extraction with capillary electrophoresis (CE) and UV detection was developed for the determination of four major indoles from four types of Brassica vegetables. Materials and Methods : Freeze-dried samples of four Brassica vegetables, i.e. broccoli, cauliflower, Chinese cabbage and cabbage, were selected. Hence, 1 mL of the binary solvent DMF (DMF)-methanol, 4:1 (volume/volume), was used for sample extraction The extracts were diluted with the running buffer and directly analyzed using CE with UV detection of four indole compounds Results : The binary solvent DMF-methanol, 4:1 (volume/volume) was selected from studies of the extraction efficiency of standard indoles spiked in ivy gourd (as the neg. control sample) and using diphenylamine as the internal standard Recovery was 80(±10)-120(±3)% for the four indoles: indole-3-carbinol (I3C), indole-3-acetonitrile (I3A), indole-3-acetic acid (IAA), and 3,3′-diindolylmethane (DIM). For direct anal. suitable dilution of the extract with the running buffer was required. The linear range of the quantitation is 0.75-25.0μg/mL, limit of detection (LOD) of 0.14-0.52μg/mL and r2 > 0.998. The amount of indole in the Brassica vegetables are in the order I3C > > IAA, I3A > DIM. Conclusion : A rapid method for extraction and quantitation of four indoles in four Brassica vegetables using CE with UV detection was developed. It has the potential as an efficient technique for generating data for use in agricultural and nutritional studies.

After consulting a lot of data, we found that this compound(1968-05-4)Application of 1968-05-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Biotransformation of (-)-nopol by Glomerella cingulata.COA of Formula: C11H18O.

The biotransformation of (-)-nopol to (4R)-(-)-4-hydroxynopol, 4-oxonopol and 5-hydroxynopol by G. cingulata was demonstrated. The structures of the biotransformation products were determined by spectral methods.

After consulting a lot of data, we found that this compound(35836-73-8)COA of Formula: C11H18O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics