Month: April 2022

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Diiodo(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12I2Pt, CAS is 12266-72-7, about Synthesis of 2,6-bis(dicyclohexylphosphinomethyl)phenyl platinum(II) complexes (2,6-(Cy2PCH2)2C6H3)PtX (X = Cl, I, OTf), the main research direction is phosphinomethylphenyl platinum halide complex preparation.Related Products of 12266-72-7.

Reaction of 1,3-(Cy2PCH2)2C6H4 with (COD)PtX2 (X = I, Cl) in mesitylene in the presence of pyridine gave title compounds, (2,6-bis(Cy2PCH2)2C6H3)PtX (I); reaction of I (X = I) with AgOTf in THF/CH2Cl2 gave I (X = OTf).

After consulting a lot of data, we found that this compound(12266-72-7)Related Products of 12266-72-7 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C17H14N2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about 3,3′-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway. Author is Zhu, Peiyao; Yu, Huayun; Zhou, Kun; Bai, Yu; Qi, Ruiqun; Zhang, Shuguang.

Abstract: Background: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive tumors in the world. Aryl hydrocarbon receptor (AHR) has been reported to promote tumor metastasis and epithelial-mesenchymal transition (EMT) is a vital process of conferring cancer cells capabilities of migration and invasion. However, the mechanism by which modulation of AHR can inhibit tumor metastasis remains unknown. Thus, we aim to investigate the underlying mechanism regarding reversing EMT process of ESCC through modulation of AHR. Methods: We used AHR selective modulator 3,3′-diindolylmethane (DIM) to treat ESCC cell lines TE1 and KYSE150 so as to examine alterations of migration and invasion by wound healing and Transwell assay. Western blotting (WB) and qPCR were performed to detect relative genes and proteins changes regarding EMT process. Cell transfection was utilized for confirming pathways involved in DIM-induced reversal of EMT and in vivo assay was conducted for verification of the underlying mechanism. Co-IP assay was conducted for detecting protein-protein interactions. Results: AHR was overexpressed in ESCC and modulation of AHR by DIM could inhibit migration and invasion as well as downregulate mesenchymal cell markers β-Catenin, Vimentin and Slug and upregulate epithelial cell marker Claudin-1. Meanwhile, synergically overexpression of AHR, RhoA and ROCK1 correlated with poor clin. outcomes. DIM could inhibit COX2/PGE2 pathway by targeting AHR, and COX2 selective inhibitor Celecoxib could suppress EMT and metastasis. Results of PGE2 treatment were opposite to that of Celecoxib. Meanwhile, blockade of RhoA/ROCK1 pathway also exerted prohibitive effects on EMT and metastasis. WB results showed COX2/PGE2 pathway could be regulated by RhoA/ROCK1 pathway and DIM could inhibit RhoA/ROCK1 pathway through modulation of AHR. In vivo assay verified the results in vitro. Co-IP results showed DIM could modulate AHR to reverse EMT directly through inhibition of interaction between AHR and EGFR (epidermal growth factor receptor) so as to block RhoA/ROCK1-mediated COX2/PGE2 pathway which was connected by NF-κB. Conclusions: In brief, modulation of AHR by DIM can reverse EMT process and inhibit metastasis of ESCC through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway.

After consulting a lot of data, we found that this compound(1968-05-4)Computed Properties of C17H14N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khomenko, Tatyana M.; Shtro, Anna A.; Galochkina, Anastasia V.; Nikolaeva, Yulia V.; Petukhova, Galina D.; Borisevich, Sophia S.; Korchagina, Dina V.; Volcho, Konstantin P.; Salakhutdinov, Nariman F. published the article 《Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication》. Keywords: dimethylbicycloheptenyl alkoxychromenone preparation antiviral SAR mol docking; F protein; antiviral activity; coumarin; cytotoxicity; molecular modelling; respiratory syncytial virus; terpene.They researched the compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8 ).Recommanded Product: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:35836-73-8) here.

It was showed, for the first time, that O-linked coumarin-monoterpene conjugates are effective RSV inhibitors. The most potent compounds were active against both RSV serotypes, A and B. According to the results of the time-of-addition experiment, the conjugates act at the early stages of virus cycle. Based on mol. modeling data, RSV F protein may be considered as a possible target.

After consulting a lot of data, we found that this compound(35836-73-8)Recommanded Product: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Organic Chemistry Frontiers called Regioselective C-H alkylation and alkenylation at the C5 position of 2-amino-1,4-naphthoquinones with maleimides under Rh(III) catalysis, Author is Yakkala, Prasanna Anjaneyulu; Giri, Deepesh; Chaudhary, Bharatkumar; Auti, Prashant; Sharma, Satyasheel, which mentions a compound: 4144-22-3, SMILESS is O=C(C=C1)N(C(C)(C)C)C1=O, Molecular C8H11NO2, Safety of 1-(tert-Butyl)-1H-pyrrole-2,5-dione.

Rhodium(III) catalyzed regioselective C-H alkylation and alkenylation at the C5 position of 1,4-naphthoquinones I [R1 = H, Me, Et; R2 = CH3(CH2)3, 4-FC6H4CH2, cyclohexylmethyl, etc.; R1R2 = -(CH2)4-, -(CH2)5-; R3 = H, Cl] with maleimides II (R = H, Me, C6H5CH2, C6H5, etc.) under acidic and basic conditions, resp., is described. The alkylamino substituents at the C2 position enabled the reaction to proceed efficiently. The alkylation reaction proceeds via a redox neutral Rh(III) pathway, whereas the alkenylation reaction takes place through the typical redox Rh(III) pathway to yield Rh(I) species.

After consulting a lot of data, we found that this compound(4144-22-3)Safety of 1-(tert-Butyl)-1H-pyrrole-2,5-dione can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Rhodium(III)-Catalyzed Redox-Neutral 1,1-Cyclization of N-Methoxy Benzamides with Maleimides via C-H/N-H/N-O Activation: Detailed Mechanistic Investigation, published in 2019-04-05, which mentions a compound: 4144-22-3, mainly applied to rhodium catalyzed redox neutral cyclization methoxybenzamide maleimide spiroisoindolinone, HPLC of Formula: 4144-22-3.

An Rh(III)-catalyzed 1,1-cyclization of N-methoxy benzamides with maleimides providing isoindolinone spirosuccinimides through N-H/C-H/N-O bond activation is described. The detailed mechanistic investigation including isolation of key metalacycle intermediate, deuterium labeling studies, and DFT calculations were performed. The computational study reveals that the AcOH that formed in the reaction medium plays a key role in the N-OMe bond cleavage and the oxidation of Rh(I) to Rh(III).

After consulting a lot of data, we found that this compound(4144-22-3)HPLC of Formula: 4144-22-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4144-22-3, is researched, SMILESS is O=C(C=C1)N(C(C)(C)C)C1=O, Molecular C8H11NO2Journal, Article, Chemistry – A European Journal called Novel Base-Free Catalytic Wittig Reaction for the Synthesis of Highly Functionalized Alkenes, Author is Schirmer, Marie-Luis; Adomeit, Sven; Spannenberg, Anke; Werner, Thomas, the main research direction is highly functionalized alkene preparation diastereoselective synthesis; organocatalytic Wittig reaction olefin aldehyde Bronsted acid additive; Wittig reactions; homogeneous catalysis; olefination; organocatalysis; ylides.Recommanded Product: 1-(tert-Butyl)-1H-pyrrole-2,5-dione.

A highly efficient catalyst system for base-free catalytic Wittig reactions has been developed and optimized. Initially, several potential (pre)catalysts as well as different silanes as reducing agents were screened. A system based on a readily available phosphine oxide as precatalyst and trimethoxy silane as reducing agent proved to be optimal. The effect of various Bronsted acidic additives was studied. Subsequently, the reaction conditions were optimized and standard reaction conditions were determined Under these conditions the scope of this new protocol was evaluated. Nine activated olefins and 33 aldehydes were converted into 42 highly functionalized alkenes. Notably, aromatic, aliphatic as well as heteroaromatic aldehydes could be converted, giving the desired products in isolated yields up to 99 % and with good to excellent E/Z selectivities. These results underline the remarkable efficiency of this protocol considering the complexity of the reaction mixture and the four reaction steps that proceed in parallel in one pot.

After consulting a lot of data, we found that this compound(4144-22-3)Recommanded Product: 1-(tert-Butyl)-1H-pyrrole-2,5-dione can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Preparation, characterization, and properties of platinum(0) complexes with tri-n-butyl phosphite, tri-n-butylarsine, and tri-n-butylstibine, published in 1985-08-28, which mentions a compound: 12266-72-7, mainly applied to platinum phosphite phosphine arsine stibine; fluorophenyl platinum hydrido phosphite, Electric Literature of C8H12I2Pt.

31P, 195Pt and 13C NMR spectroscopy was used to characterize the products of the reaction of [Pt(cod)2] (cod = 1,5-cyclooctadiene) and n equivalent of a ligand L (n = 4, L = P(OBu)3, AsBu3 and SbBu3; n = 2 and 3, L = P(OBu)3. When n = 4, a single isolable [PtL4] is formed which is kinetically inert in solution at room temperature For n = 3 and L = P(OBu)3, and mixture of [PtL3] and [PtL4] is formed and when n = 2 and L = P(OBu)3, both [PtL4] and [PtL3] are present, together with a new species arising from solvent interaction. Evidence is presented which suggests that this new compound is [Pt(η2-L1)L2] and (L1 = olefin) and exist 3 isomeric forms. Very slow dynamic behavior of this compound is observed in solution at low temperatures, but on heating a change of isomeric ratios occurs. [PtL3] (L = P(OBu)3) reacts with the C-H bond in C6F5H to yield trans-[PtH(C6F5)L2] an unstable derivative observed only in solution

After consulting a lot of data, we found that this compound(12266-72-7)Electric Literature of C8H12I2Pt can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C8H11NO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about A first case of asymmetric catalysis induced by metal-free bisoxazolines.

Metal-free bisoxazolines catalyze the Diels-Alder reaction of N-substituted maleimides with anthrone derivatives leading to products in excellent yields and enantioselectivities up to 70%. A mechanism relying on Broensted-base catalysis is assumed to be involved with formation of an ion pair between the protonated catalyst and the anthrone enolate, which acts as a diene.

After consulting a lot of data, we found that this compound(4144-22-3)Formula: C8H11NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Supramolecular Recognition. Terpyridyl Palladium and Platinum Molecular Clefts and Their Association with Planar Platinum Complexes, published in 2003-01-15, which mentions a compound: 12266-72-7, mainly applied to platinum cofacially linked terpyridyl complex preparation association platinum complex; palladium cofacially linked terpyridyl complex association platinum complex; formation constant platinum palladium cofacially linked terpyridyl platinum complex; crystal structure platinum cofacially linked terpyridyl complex platinum hydroxyphenyliminomethylphenolato, Recommanded Product: Diiodo(1,5-cyclooctadiene)platinum(II).

Mol. receptors, consisting of either two parallel cofacially disposed terpyridyl-Pd-Cl+ or terpyridyl-Pt-Cl+ units, are described. Concerted rotation of these units about the mol. spacer can alter their separation between 6.4 and 7.2 Å to accommodate the dimensions of mol. guests. Neutral and anionic planar complexes of Pt(II) were studied as guests to determine if metal-metal interaction between the host and guest metals could stabilize host-guest association With a neutral guest, host-guest formation is signaled by a color change from light yellow to deep red. For one of the anionic guests, a visible absorption band appears upon host-guest formation with the Pt receptor that is ascribed to transitions associated with a Pt-Pt interaction. The association constants found for the neutral guest with the Pd and Pt receptors are large, suggesting that metal-metal interaction contributes to the mol. recognition. The structures of the host-(neutral)guest complexes in solution were determined by 1H NOESY spectra. A crystal structure of the Pt host-(neutral)guest complex is the same as that found in solution and confirms the presence of a Pt-Pt interaction. Temperature-dependent 195Pt NMR spectra in solution provide a quant. estimate of the conformational interconversions of the free Pt receptor.

Although many compounds look similar to this compound(12266-72-7)Recommanded Product: Diiodo(1,5-cyclooctadiene)platinum(II), numerous studies have shown that this compound(SMILES:I[Pt]I.C1=CCC/C=CCC/1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C8H11NO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Chlorophyll-Catalyzed Visible-Light-Mediated Synthesis of Tetrahydroquinolines from N,N-Dimethylanilines and Maleimides. Author is Guo, Jun-Tao; Yang, Da-Cheng; Guan, Zhi; He, Yan-Hong.

Natural pigment chlorophyll was used as a green photosensitizer for the first time in a visible-light photoredox catalysis for the efficient synthesis of tetrahydroquinolines from N,N-dimethylanilines and maleimides in an air atm. The reaction involves direct cyclization via an sp3 C-H bond functionalization process to afford products in moderate to high yields (61-98%) from a wide range of substrates with a low loading of chlorophyll under mild conditions. This work demonstrates the potential benefits of chlorophyll as photosensitizer in visible light catalysis.

Although many compounds look similar to this compound(4144-22-3)Computed Properties of C8H11NO2, numerous studies have shown that this compound(SMILES:O=C(C=C1)N(C(C)(C)C)C1=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics