Month: September 2022

Gladisch, Fabian C.;van Leusen, Jan;Passia, Marco T.;Kogerler, Paul;Steinberg, Simon published 《Rb₃Er₄Cu₅Te₁₀: Exploring the Frontier between Polar Intermetallics and Zintl-Phases via Experimental and Quantumchemical Approaches》 in 2021. The article was appeared in 《European Journal of Inorganic Chemistry》. They have made some progress in their research.Category: chlorides-buliding-blocks The article mentions the following:

The tailored design of solid-state materials requires a proper understanding of their resp. electronic structures. In order to rationalize the relationships between crystal structures and electronic structures in intermetallic compounds, the Zintl-Klemm concept has been frequently employed. Yet, the frontier between the valence-electron concentrations (e/a) of the Zintl- and the polar intermetallic phases has remained unclear to date. To shed some light on this frontier, we explored the electronic structure of the quaternary compound Rb₃Er₄Cu₅Te₁₀. To this effect, the crystal structure of this telluride, which was obtained as pure phase from high-temperature reactions, was determined by means of X-ray diffraction experiments for the very first time. In addition, the magnetic properties of the Rb₃Er₄Cu₅Te₁₀ were also determined in order to explore the erbium 4 f states in more detail.Rubidiumchloride (cas: 7791-11-9) were involved in the experimental procedure.

Rubidium chloride(cas: 7791-11-9) is the mostly used rubidium compound, and finds use in various fields ranging from electrochemistry to molecular biology.Category: chlorides-buliding-blocks It is an efficient non-invasive biomarker; increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Moreno, Carlos;Bybee, Ellie;Tellez Freitas, Claudia M.;Pickett, Brett E.;Weber, K. Scott published 《Meta-Analysis of Two Human RNA-seq Datasets to Determine Periodontitis Diagnostic Biomarkers and Drug Target Candidates》 in 2022. The article was appeared in 《International Journal of Molecular Sciences》. They have made some progress in their research.Formula: C15H17ClFNO4S The article mentions the following:

Periodontitis is a chronic inflammatory oral disease that affects approx. 42% of adults 30 years of age or older in the United States. In response to microbial dysbiosis within the periodontal pockets surrounding teeth, the host immune system generates an inflammatory environment in which soft tissue and alveolar bone destruction occur. The objective of this study was to identify diagnostic biomarkers and the mechanistic drivers of inflammation in periodontitis to identify drugs that may be repurposed to treat chronic inflammation. A meta-anal. comprised of two independent RNA-seq datasets was performed. RNA-seq anal., signal pathway impact anal., protein-protein interaction anal., and drug target anal. were performed to identify the critical pathways and key players that initiate inflammation in periodontitis as well as to predict potential drug targets. Seventy-eight differentially expressed genes, 10 significantly impacted signaling pathways, and 10 hub proteins in periodontal gingival tissue were identified. The top 10 drugs that may be repurposed for treating periodontitis were then predicted from the gene expression and pathway data. The efficacy of these drugs in treating periodontitis has yet to be investigated. However, this anal. indicates that these drugs may serve as potential therapeutics to treat inflammation in gingival tissue affected by periodontitis. The experimental procedure involved many compounds, such as (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (cas: 243984-11-4) .

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate(cas:243984-11-4) can reduces lesion volume in a mouse model of cerebral cavernous malformations (CCMs).Formula: C15H17ClFNO4S Also attenuates increased cytokine levels in a mouse sepsis model, when given in combination with ceftazidime. Cell permeable.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Caixia;Sui, Guanghong;Wang, Lu;Chen, Zheng;Wang, Feng published 《MiR-124 Prevents the Microglial Proinflammatory Response by Inhibiting the Activities of TLR4 and Downstream NLRP3 in Palmitic Acid-Treated BV2 Cells》 in 2022. The article was appeared in 《Journal of Molecular Neuroscience》. They have made some progress in their research.Application In Synthesis of (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate The article mentions the following:

Neuroinflammation is a mechanism by which obesity or a high-fat diet leads to cognitive impairment. MiR-124, a highly expressed microRNA in the brain, can alleviate neuroinflammation by regulating microglial activation, but its mechanism is unclear. The aim of the study was to explore whether miR-124 exerted this effect through TLR4/MyD88/NF-κB p65/NLRP3 signaling in palmitic acid-treated BV2 cells. Prepared BV2 cells were treated with palmitic acid to establish an in vitro model of a high-fat diet. An miR-124 mimic and inhibitor were adopted to upregulate and downregulate the expression of miR-124, resp. TAK-242 and NLRP3 siRNA were used to downregulate the expression of TLR4 and NLRP3. The expression levels of miR-124, signaling proteins (TLR4, MyD88, and NF-κB p65), inflammasome markers (NLRP3 and IL-1β), and microglial activated markers (CD206, Arg-1, CD86, and iNOS) were measured by qPCR and western blotting. The pyroptosis rate was assessed using flow cytometry. First, palmitic acid upregulated TLR4/MyD88/NF-κB p65 signaling, increased NLRP3 expression, elevated the pyroptosis rate, and promoted the microglial proinflammatory response in BV2 cells. Second, the miR-124 mimic and inhibitor sep. alleviated and aggravated the effect of palmitic acid on microglial activation and NLRP3 expression. The miR-124 mimic also downregulated TLR4/MyD88/NF-κB p65 signaling. Third, TAK-242 did not affect the expression of miR-124 but simulated the protective effect of the miR-124 mimic on microglial activation and NLRP3 expression. Fourth, NLRP3 siRNA also inhibited the microglial proinflammatory response in BV2 cells. MiR-124 prevented the microglial proinflammatory response through TLR4/MyD88/NF-κB p65/NLRP3 signaling in palmitic acid-treated BV2 cells. To complete the study, the researchers used (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (cas: 243984-11-4) .

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate(cas:243984-11-4) is a toll-like receptor 4 (TLR4) signaling inhibitor.Application In Synthesis of (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate And it can inhibits LPS-induced cytokine production in vitro (IC50 values are 1.3, 1.3 and 3.2 nM for IL-6, TNFα and NO production).

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cai, Libo;Zhu, Xiaoyi;Chen, Jiayi;Lin, Aijun;Yao, Hequan published 《Rh(III)-Catalyzed C-H activation/annulation of salicylaldehydes with sulfoxonium ylides for the synthesis of chromones》 in 2019. The article was appeared in 《Organic Chemistry Frontiers》. They have made some progress in their research.Application In Synthesis of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) The article mentions the following:

A rhodium(III)-catalyzed C-H activation/annulation of salicylaldehydes e.g., 2-OHC₆H₄CHO with sulfoxonium ylides RC(O)CH=S(O)(CH₃)CH₃ (R = Ph, t-Bu, cyclohexyl, thiophen-2-yl, etc.) has been developed for the formation of 2-substituted chromones e.g., I in good yields with broad functional group tolerance. The utility of this strategy was showcased by the late-stage modification of some biol. active mols. Moreover, structurally diverse 2,3-disubstituted chromones II (R¹ = Cl, CF₃, diethoxyphosphoroso, etc.) were also constructed by the C3 C-H functionalization reactions. To complete the study, the researchers used (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Application In Synthesis of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Geum, Na Gyeong;Yu, Ju-Hyeong;Yeo, Joo Ho;Choi, Min Yeong;Lee, Jae Won;Beak, Jueng Kyu;Jeong, Jin Boo published 《Immunostimulatory activity and anti-obesity activity of Hibiscus manihot leaves in mouse macrophages, RAW264.7 cells and mouse adipocytes, 3T3-L1 cells》 in 2021. The article was appeared in 《Journal of Functional Foods》. They have made some progress in their research.SDS of cas: 243984-11-4 The article mentions the following:

In this study, we investigated whether Hibiscus manihot leaves (HML) exhibits immune-enhancing activity and anti-obesity in RAW264.7 and 3T3-L1 cells. HML increased the production of inflammatory mols., cell viability and phagocytosis in RAW264.7 cells. TLR2 and TLR4 blocked HML-mediated production of inflammatory mols. in RAW264.7 cells. In addition, the inhibition of MAPK signaling pathway reduced HML-mediated production of inflammatory mols. and the activation of MAPK signaling pathway by HML suppressed the inhibition of TLR2/4. HML reduced the lipid accumulation and TG contents in 3T3-L1 cells. HML inhibited the protein expressions such as CEBPα, PPARγ, perilipin-1, adiponectin and FABP4 related to the lipid accumulation of the mature adipocytes. In addition, HML reduced CEBPα and PPARγ during the differentiation process from preadipocytes to mature adipocytes. The experimental procedure involved many compounds, such as (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (cas: 243984-11-4) .

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate(cas:243984-11-4) is a toll-like receptor 4 (TLR4) signaling inhibitor.SDS of cas: 243984-11-4 And it can inhibits LPS-induced cytokine production in vitro (IC50 values are 1.3, 1.3 and 3.2 nM for IL-6, TNFα and NO production).

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of ClRb《Selective extraction of cesium from high concentration rubidium chloride leach liquor of lepidolite》 was published in 2022. The authors were Lv, Yingwei;Ma, Baozhong;Liu, Yubo;Wang, Chengyan;Zhang, Wenjuan;Chen, Yongqiang, and the article was included in《Desalination》. The author mentioned the following in the article:

A special extractant, 4-tert-butyl-2-(α-methylbenzyl) phenol (t-BAMBP), was applied in cesium separation and purification from high concentration of rubidium chloride leach liquor. Effects of various parameters, such as feed liquid alkalinity, reagent concentration, contact time, and phase ratio, on extraction, scrubbing and stripping were systematic studied. The results demonstrated that the extraction rate of cesium reached 99.18% after five-stage countercurrent extraction, with the optimal extraction conditions that a feed liquid initial alkalinity of 10 g/L, t-BAMBP concentration of 1 mol/L, contact time of 1 min, and phase ratio (O/A) of 1:4. In addition, the loaded organic phase coextd. impurity elements (15.78% Rb, 0.5% K) was scrubbed with 0.1 mol/L HCl. After four-stage countercurrent scrubbing, the scrubbing rates of rubidium and potassium were 99.83% and 100% resp., as well as 5.73% of cesium was lost. Almost all cesium (99%) was stripped with 0.05 mol/L HCl by two-stage countercurrent stripping after the organic phase was scrubbed. The slope method calculated the composition of the extraction complex as CsOR • 2ROH(o), and the cation exchange reaction was proven to be the extraction mechanism. And Rubidiumchloride (cas: 7791-11-9) was used in the research process.

Rubidium chloride(cas: 7791-11-9) can increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.Computed Properties of ClRb Pharmaceutical compositions have been used as antidepressants in Europe. It is employed in biochemistry to induce cells to take up DNA.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thiet Vu, Thi;Daro, Nathalie;Marchivie, Mathieu;Mornet, Stephane;Freysz, Eric;Chastanet, Guillaume published 《Rational Direct Synthesis of RbMnFe Nanoparticles (RbMnFe = Rb_xMn[Fe(CN)₆]_(2+x)/3·nH₂O Prussian Blue Analogue)》 in 2022. The article was appeared in 《Inorganic Chemistry》. They have made some progress in their research.Recommanded Product: Rubidiumchloride The article mentions the following:

The authors report the chem. strategy followed to obtain, in a direct way, nanoparticles of the Rb_xMn[Fe(CN)₆]_(x+2)/3·nH₂O (RbMnFe) Prussian blue analog with the aim of keeping the switching ability of this compound at the nanoscale. The switching property comes from a reversible electron transfer between the Fe and Mn ions and depends on the Rb content in the structure that has to be >0.6. Despite the multifunctionality of this family of compounds and its interest in various applications, no systematic studies were performed to obtain well-defined nanoparticles. This paper relates to such a study. To draw relation between size reduction, composition, and switching properties, a special attention was brought to the determination of the composition through elemental anal. and structure refinement of powder x-ray diffraction patterns together with IR spectroscopy and elemental anal. Several chem. parameters were explored to control both the size reduction and the composition following a direct synthetic approach. The smaller the particles, the lower the Rb content. This observation might prevent the observation of switching properties on very small particles. Despite this antagonist effect, the authors achieved switchable particles of ∼200 nm without any use of surfactant. Also, the size reduction is associated with the observation of the electron transfer down to 52% of Rb in the nanoparticles against 64% in microparticles. This work is of particular interest in processing such nanoparticles into devices. The experimental procedure involved many compounds, such as Rubidiumchloride (cas: 7791-11-9) .

Rubidium chloride(cas: 7791-11-9) is the mostly used rubidium compound, and finds use in various fields ranging from electrochemistry to molecular biology.Recommanded Product: Rubidiumchloride It is an efficient non-invasive biomarker; increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Mingxu;Yang, Yang;Wu, Miaomiao;Ma, Fang;Xu, Yue;Deng, Bihua;Zhang, Jinqiu;Zhu, Guoqiang;Lu, Yu published 《Role of long polar fimbriae type 1 and 2 in pathogenesis of mammary pathogenic Escherichia coli》. The research results were published in《Journal of Dairy Science》 in 2021.Related Products of 243984-11-4 The article conveys some information:

Escherichia coli is a leading cause of bovine mastitis worldwide. The bacteria can rapidly grow in milk and elicit a strong lipopolysaccharide (LPS)/toll-like receptor-4 (TLR4)-dependent inflammatory response. Recently, the long polar fimbriae (LPF) were identified as a promising virulence factor candidate widely distributed in mammary pathogenic E. coli (MPEC) strains. Mammary pathogenic E. coli possess 2 lpf loci encoding LPF1 and LPF2, resp. By deleting the major fimbrial subunit gene, lpfA, we found that both LPF1 and LPF2 contribute to MPEC adhesion, invasion, and biofilm formation in vitro. The lpf1A and lpf2A mutants showed reduced cytotoxicity in our in vitro cell infection model. Furthermore, we observed that LPF2 induced a mild TLR4-independent proinflammatory response. The median LD (LD50) of both Δlpf2A and Δlpf1AΔlpf2A mutants to BALB/c mice increased by 0.38 and 0.15 logs, resp., whereas that of wild-type strain MPJS13 was 8.69 logs. In contrast, LPF1 deficiency significantly enhanced the LPS/TLR4-mediated inflammatory response in mammary epithelial cells, and the LD50 of the mutant decreased to 8.18 logs. In conclusion, our data suggested that LPF are important in MPEC colonization of mammary cells and may provide a benefit to bacterial intracellular survival that induces persistent bovine mastitis. And (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (cas: 243984-11-4) was used in the research process.

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate(cas:243984-11-4) is a toll-like receptor 4 (TLR4) signaling inhibitor.Related Products of 243984-11-4 And it can inhibits LPS-induced cytokine production in vitro (IC50 values are 1.3, 1.3 and 3.2 nM for IL-6, TNFα and NO production).

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Su, Xiaonan;Ma, Xiaowen;Xie, Xiaoyu;Wu, Hao;Wang, Le;Feng, Yuemin;Yu, Zhen;Liu, Chenxi;Qi, Jianni;Zhu, Qiang published 《FN-EDA mediates angiogenesis of hepatic fibrosis via integrin-VEGFR2 in a CD63 synergetic manner》. The research results were published in《Cell Death Discovery》 in 2020.Application In Synthesis of (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate The article conveys some information:

Pathol. angiogenesis is an important component of hepatic fibrosis along with fibrous deposition, but its role is not well understood. Here, we demonstrated that fibronectin containing extra domain A(FN-EDA), a fibronectin splice variant highly expressed in hepatic fibrosis, mediated angiogenesis in disease progression. FN-EDA was pos. correlated with pathol. angiogenesis in hepatic fibrosis, and a reduction in FN-EDA expression was associated with diminished intrahepatic angiogenesis and fibrosis. FN-EDA mostly colocalized with hepatic stellate cells (HSCs) and interference or blockage of FN-EDA attenuated migration and tube formation in co-cultured endothelial cells. Mechanistic studies indicated that FN-EDA was secreted to promote phosphorylation of VEGFR2 with the assistance of integrin and CD63. Targeting FN-EDA-integrin combination postponed the progression of hepatic angiogenesis and fibrosis in vivo. These results indicated that FN-EDA plays an emerging role in angiogenesis in hepatic fibrosis and could be a potential therapeutic intervention for the disease. To complete the study, the researchers used (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (cas: 243984-11-4) .

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate(cas:243984-11-4) is a toll-like receptor 4 (TLR4) signaling inhibitor.Application In Synthesis of (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate And it can inhibits LPS-induced cytokine production in vitro (IC50 values are 1.3, 1.3 and 3.2 nM for IL-6, TNFα and NO production).

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Jian;Zhao, He;Tan, Zhenda;Cao, Liang;Jiang, Huanfeng;Ci, Chenggang;Dixneuf, Pierre H.;Zhang, Min published 《syn-Selective Construction of Fused Heterocycles by Catalytic Reductive Tandem Functionalization of N-Heteroarenes》 in 2021. The article was appeared in 《ACS Catalysis》. They have made some progress in their research.Formula: C10H13ClO3 The article mentions the following:

To date, numerous methods have been successfully developed to functionalize N-heteroaryl C-H bonds. In contrast, dearomative tandem functionalization of N-heteroarenes is still a subject to be explored. Reported herein is an example on reductive dearomatization-induced tandem functionalization of N-heteroarenes by ruthenium catalysis, which offers a general method for diastereoselective construction of fused heterocycles featuring a cyclic syn-N, O-acetal motif from N-heteroarenes, phenols, and paraformaldehyde. Mechanistic study reveals that the products are formed via a tandem sequence of pyridyl C₃-benzylation and hydroxymethylation followed by C₂-aryloxylation of N-heteroarenium salts, proceeding with broad substrate scope, good functional group tolerance, high atom efficiency, and applicability for postfunctionalization of some biomedical mols.(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) were involved in the experimental procedure.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Formula: C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics