Xu, Weichu;Wright, George E.;Yanachkova, Milka;Yanachkov, Ivan B. published 《Synthesis and absolute configuration assignment of 9-hydroxyrisperidone enantiomers》 in 2014. The article was appeared in 《Letters in Organic Chemistry》. They have made some progress in their research.COA of Formula: C10H13ClO3 The article mentions the following:
The enantiomers of 9-hydroxyrisperidone, the major metabolite of risperidone and the active component of the antipsychotic drug Invega, were synthesized by efficient methods. Their optical rotation and enantiomeric purity were characterized. The absolute configurations were assigned by comparing 1H NMR chem. shifts of Mosher esters of a key stereoisomeric intermediate. Thus, the stereoisomeric center of (+)-9-hydroxyrisperidone was assigned the S configuration, and its enantiomer has the configuration R. And (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) was used in the research process.
(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 COA of Formula: C10H13ClO3) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics