The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Computed Properties of 349-88-2.
Xie, Dandan;Hu, Xin;Ren, Xiaoli;Yang, Zaiping research published 《 Synthesis and bioactivities of novel piperonylic acid derivatives containing a sulfonic acid ester moiety》, the research content is summarized as follows. In order to develop efficient, broad-spectrum and structurally simple agricultural bactericide, the structure of piperonylic acid was modified and a series of novel piperonylic acid derivatives I [R = Ph, 2-naphthyl, benzyl, etc.] containing a sulfonic acid ester moiety was synthesized. Bioassay results indicated the compounds I exhibited significantly antibacterial activities. Among them, compound I [R = phenyl] exhibited excellent antibacterial activities against Pseudomonas syringae pv. Actinidiae (Psa), with inhibitory value 99 and 85% at 100μg/mL and 50μg/mL, resp., which was higher than that of thiodiazole-copper (84 and 77%) and bismerthiazol (96 and 78%). In addition, some compounds also showed moderate insecticidal activity against Spodoptera frugiperda. The above mentioned results confirm the broadening of the application of piperonylic acid, with reliable support for the development of novel agrochem. bactericide.
Computed Properties of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics