Qin, Linlin;Ren, Lei;Wan, Songlin;Liu, Guoliang;Luo, Xinfeng;Liu, Zhenhong;Li, Fangqiong;Yu, Yan;Liu, Jianyu;Wei, Yonggang published 《Design, Synthesis, and Evaluation of Novel 2,6-Disubstituted Phenol Derivatives as General Anesthetics》 in 2017. The article was appeared in 《Journal of Medicinal Chemistry》. They have made some progress in their research.Related Products of 39637-74-6 The article mentions the following:
A novel series of optically active 2,6-disubstituted alkylphenols with improved anesthetic profiles compared to widely used propofol were synthesized. The incorporation of the cyclopropyl group not only increased the steric effect but also introduced stereoselective effects over their anesthetic properties. Compounds I (R = Et, R1 = cyclopropyl; R = R1 = cyclopropyl; R = Me, R1 = cyclopropyl) were selected as potential candidates for further preclin. development including studies of their water-soluble prodrugs. Clin. studies of candidate compound I (R = Me, R1 = cyclopropyl) (Haisco HSK3486) as a general anesthetic are being performed in Australia and China. The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .
(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Related Products of 39637-74-6) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics