The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Product Details of C6H4BrClO2S.
Arshad, Mohammad;Beg, Amjad Md;Abdul R Bhat;Athar, Fareeda research published 《 Synthesis, structure elucidation and antibacterial screening of some novel 1,3,4-oxadiazoline derivatives》, the research content is summarized as follows. A novel sequence of 1,3,4-oxadiazoline derivatives has been synthesized with an endeavour to explore their consequence on in vitro growth of microbes causing the microbial contagion. In vitro antimicrobial activity has been performed against the Escherichia coli (E. coli) and Proteus mirabilis (P. mirabilis) which are Gram-neg. (Gram-ve) and Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermis) which are Gram-pos. (Gram+ve) by using disk diffusion method. The min. inhibitory concentration (MIC) has been distinguished by employing the double dilution method. The result of percent inhibition area/μg of the compounds has been differentiated with the standard drug “Ciprofloxacin”. Several compounds portray excellent activity as compared to the standard drug Ciprofloxacin while some of them presented a considerable zone of inhibition. The evaluated compounds for cytotoxicity effects via Human hepatocellular carcinoma (HepG2) cell line by MTT-assay and findings reveal that the exptl. compounds display a viability of ≥80% at 100μM. In mol. docking studies, the 1,3,4-oxadiazoline derivatives demonstrate the ligand-receptor interaction with amino acids which exist on the active sites of the peptide deformylase and the 1,3,4-oxadiazoline derivatives exhibit their antibacterial potential as peptide deformylase inhibitors.
Product Details of C6H4BrClO2S, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics