Chlorinated organic compounds are found in nearly every class of biomolecules. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. SDS of cas: 3900-89-8.
Brem, Jurgen;Panduwawala, Tharindi;Hansen, Jon Ulf;Hewitt, Joanne;Liepins, Edgars;Donets, Pawel;Espina, Laura;Farley, Alistair J. M.;Shubin, Kirill;Campillos, Gonzalo Gomez;Kiuru, Paula;Shishodia, Shifali;Krahn, Daniel;Lesniak, Robert K.;Schmidt, Juliane;Calvopina, Karina;Turrientes, Maria-Carmen;Kavanagh, Madeline E.;Lubriks, Dmitrijs;Hinchliffe, Philip;Langley, Gareth W.;Aboklaish, Ali F.;Eneroth, Anders;Backlund, Maria;Baran, Andrei G.;Nielsen, Elisabet I.;Speake, Michael;Kuka, Janis;Robinson, John;Grinberga, Solveiga;Robinson, Lindsay;McDonough, Michael A.;Rydzik, Anna M.;Leissing, Thomas M.;Jimenez-Castellanos, Juan Carlos;Avison, Matthew B.;Da Silva Pinto, Solange;Pannifer, Andrew D.;Martjuga, Marina;Widlake, Emma;Priede, Martins;Hopkins Navratilova, Iva;Gniadkowski, Marek;Belfrage, Anna Karin;Brandt, Peter;Yli-Kauhaluoma, Jari;Bacque, Eric;Page, Malcolm G. P.;Bjorkling, Fredrik;Tyrrell, Jonathan M.;Spencer, James;Lang, Pauline A.;Baranczewski, Pawel;Canton, Rafael;McElroy, Stuart P.;Jones, Philip S.;Baquero, Fernando;Suna, Edgars;Morrison, Angus;Walsh, Timothy R.;Schofield, Christopher J. research published 《 Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors》, the research content is summarized as follows. Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-β-lactamases (MBLs). Here we report the discovery and optimization of potent broad-spectrum MBL inhibitors. A high-throughput screen for NDM-1 inhibitors identified indole-2-carboxylates (InCs) as potential β-lactamase stable β-lactam mimics. Subsequent structure-activity relationship studies revealed InCs as a new class of potent MBL inhibitor, active against all MBL classes of major clin. relevance. Crystallog. studies revealed a binding mode of the InCs to MBLs that, in some regards, mimics that predicted for intact carbapenems, including with respect to maintenance of the Zn(II)-bound hydroxyl, and in other regards mimics binding observed in MBL-carbapenem product complexes. InCs restore carbapenem activity against multiple drug-resistant Gram-neg. bacteria and have a low frequency of resistance. InCs also have a good in vivo safety profile, and when combined with meropenem show a strong in vivo efficacy in peritonitis and thigh mouse infection models. [graphic not available: see fulltext]
SDS of cas: 3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics