Application of 39637-74-6In 2017, Huang, Zhongping;Williams, Russell B.;O’Neil-Johnson, Mark;Eldridge, Gary R.;Mangette, John E.;Starks, Courtney M. published 《A Total Synthesis of Bifidenone》. 《Journal of Organic Chemistry》published the findings. The article contains the following contents:
The first total synthesis of bifidenone (I), a novel natural tubulin polymerization inhibitor, has been achieved in 12 steps starting from com. available 1,4-dioxaspiro[4.5]decan-8-one. The synthesis includes a newly developed method to generate the dihydrobenzodioxolone core by palladium-catalyzed aerobic dehydrogenation. The three stereocenters were installed with an AD-mix-β dihydroxylation step followed by a late-stage palladium-catalyzed decarboxylation-allylation procedure. The absolute stereochem. was determined by single-crystal X-ray anal. of a derivative To complete the study, the researchers used (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .
(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Application of 39637-74-6) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics